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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for POU5F1_POU2F3
Z-value: 1.00
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.30 | 7.0e-01 | Click! |
| POU2F3 | hg19_v2_chr11_+_120107344_120107351 | -0.14 | 8.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 1.8 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.0 | 1.6 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 1.1 | GO:2000257 | regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257) |
| 0.1 | 0.8 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.1 | 0.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.8 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.2 | 0.6 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) |
| 0.2 | 0.6 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.2 | 0.5 | GO:0061386 | closure of optic fissure(GO:0061386) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.6 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.4 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.4 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.3 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.3 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 1.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.0 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 0.6 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.1 | 0.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.5 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.1 | 0.5 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 0.5 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 0.4 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.1 | 0.4 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.2 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.6 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.4 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.4 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |