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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for POU3F3_POU3F4
Z-value: 1.39
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Transcription factors associated with POU3F3_POU3F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F3 | hg19_v2_chr2_+_105471969_105471969 | 0.99 | 7.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_45670924 Show fit | 1.29 |
ENST00000396659.3
|
glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
|
| chr17_-_64216748 Show fit | 0.97 |
ENST00000585162.1
|
apolipoprotein H (beta-2-glycoprotein I) |
|
| chr15_-_45670717 Show fit | 0.88 |
ENST00000558163.1
ENST00000558336.1 |
glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
|
| chr12_-_42631529 Show fit | 0.79 |
ENST00000548917.1
|
YY1 associated factor 2 |
|
| chr8_-_64080945 Show fit | 0.78 |
ENST00000603538.1
|
YTHDF3 antisense RNA 1 (head to head) |
|
| chr16_-_10652993 Show fit | 0.77 |
ENST00000536829.1
|
epithelial membrane protein 2 |
|
| chr16_-_28192360 Show fit | 0.77 |
ENST00000570033.1
|
exportin 6 |
|
| chr1_+_161035655 Show fit | 0.69 |
ENST00000600454.1
|
Uncharacterized protein |
|
| chr11_-_111649015 Show fit | 0.65 |
ENST00000529841.1
|
RP11-108O10.2 |
|
| chr9_-_14322319 Show fit | 0.55 |
ENST00000606230.1
|
nuclear factor I/B |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F3_POU3F4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.2 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.1 | 1.0 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.1 | 0.8 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.0 | 0.8 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.1 | 0.7 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.7 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.6 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 0.6 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.0 | 0.6 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 0.5 | GO:0044334 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.8 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.7 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 0.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 0.4 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 0.3 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.0 | 0.3 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0015067 | amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068) |
| 0.3 | 1.0 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 0.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.8 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 0.7 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.6 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.0 | 0.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.5 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 0.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.4 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.5 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.5 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.4 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 0.0 | 0.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |