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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for POU2F2_POU3F1
Z-value: 1.29
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636617_42636632 | -0.73 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_38171681 Show fit | 2.27 |
ENST00000225474.2
ENST00000331769.2 ENST00000394148.3 ENST00000577675.1 |
colony stimulating factor 3 (granulocyte) |
|
| chr17_+_38171614 Show fit | 1.95 |
ENST00000583218.1
ENST00000394149.3 |
colony stimulating factor 3 (granulocyte) |
|
| chr6_+_27114861 Show fit | 1.27 |
ENST00000377459.1
|
histone cluster 1, H2ah |
|
| chr6_-_26124138 Show fit | 1.24 |
ENST00000314332.5
ENST00000396984.1 |
histone cluster 1, H2bc |
|
| chr6_-_26043885 Show fit | 1.03 |
ENST00000357905.2
|
histone cluster 1, H2bb |
|
| chr6_-_27860956 Show fit | 1.03 |
ENST00000359611.2
|
histone cluster 1, H2am |
|
| chr11_-_129872672 Show fit | 1.02 |
ENST00000531431.1
ENST00000527581.1 |
PR domain containing 10 |
|
| chr7_-_100183742 Show fit | 0.94 |
ENST00000310300.6
|
leucine-rich repeats and calponin homology (CH) domain containing 4 |
|
| chr9_-_35658007 Show fit | 0.90 |
ENST00000602361.1
|
RNA component of mitochondrial RNA processing endoribonuclease |
|
| chr6_+_26183958 Show fit | 0.90 |
ENST00000356530.3
|
histone cluster 1, H2be |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.2 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.0 | 3.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 2.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.4 | 1.5 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.0 | 1.2 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.1 | 1.1 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.1 | 0.9 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.9 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 0.7 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
| 0.0 | 0.7 | GO:0033004 | negative regulation of mast cell activation(GO:0033004) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 0.7 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.7 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.6 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 0.4 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 0.3 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.0 | 2.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 2.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.3 | 1.1 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.0 | 0.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 0.6 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.1 | 0.6 | GO:0004331 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.2 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.7 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 0.6 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.6 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.5 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.4 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.4 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |