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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for PLAGL1
Z-value: 4.07
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144329384_144329405 | -0.99 | 7.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_45161301 Show fit | 3.84 |
ENST00000467908.1
|
pyridoxal (pyridoxine, vitamin B6) kinase |
|
| chr20_-_35580104 Show fit | 3.02 |
ENST00000373694.5
|
SAM domain and HD domain 1 |
|
| chr20_-_62203808 Show fit | 2.79 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr2_+_121493717 Show fit | 2.72 |
ENST00000418323.1
|
GLI family zinc finger 2 |
|
| chr19_+_16254488 Show fit | 2.66 |
ENST00000588246.1
ENST00000593031.1 |
hematopoietic SH2 domain containing |
|
| chr12_-_121476959 Show fit | 2.48 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr11_+_64053311 Show fit | 2.48 |
ENST00000540370.1
|
G protein-coupled receptor 137 |
|
| chr22_-_50970506 Show fit | 2.37 |
ENST00000428989.2
ENST00000403326.1 |
outer dense fiber of sperm tails 3B |
|
| chr3_-_45267760 Show fit | 2.35 |
ENST00000503771.1
|
transmembrane protein 158 (gene/pseudogene) |
|
| chr11_-_615570 Show fit | 2.31 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
interferon regulatory factor 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 7.7 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 6.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.1 | 5.3 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.0 | 5.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.8 | 4.8 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 4.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.4 | 4.3 | GO:0009443 | pyridoxal 5'-phosphate salvage(GO:0009443) |
| 1.1 | 4.3 | GO:0061364 | apoptotic process involved in luteolysis(GO:0061364) |
| 0.4 | 4.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 9.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 8.5 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 7.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 7.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 6.4 | GO:0034705 | potassium channel complex(GO:0034705) |
| 0.1 | 5.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 5.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 5.6 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 5.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 11.0 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 9.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 8.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 7.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.7 | 5.8 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
| 0.1 | 5.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.5 | 5.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.5 | 5.3 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.1 | 5.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 14.9 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 11.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 5.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 5.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 5.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 5.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 5.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 10.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 9.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 8.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 8.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 7.7 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.5 | 6.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 5.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 5.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 4.6 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |