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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for PITX3
Z-value: 2.21
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Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | 0.42 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion(GO:0034116) |
| 0.1 | 2.1 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.2 | 1.9 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.1 | 1.8 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.3 | 1.7 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.2 | 1.7 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.5 | 1.6 | GO:0000921 | septin ring assembly(GO:0000921) septin ring organization(GO:0031106) |
| 0.2 | 1.6 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 0.0 | 1.6 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.5 | 1.4 | GO:2001190 | peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 2.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 2.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.4 | 1.9 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 1.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 1.6 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 1.6 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 1.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 1.2 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 2.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 1.5 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 1.4 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 1.4 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 1.2 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 1.2 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 1.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 3.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.5 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 1.4 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 1.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 1.2 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |