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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for PITX1
Z-value: 3.04
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Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg19_v2_chr5_-_134369973_134369988 | 0.16 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_20731541 Show fit | 3.11 |
ENST00000292729.8
|
ubiquitin specific peptidase 41 |
|
| chr19_+_54609230 Show fit | 1.83 |
ENST00000420296.1
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa |
|
| chr17_+_41158742 Show fit | 1.81 |
ENST00000415816.2
ENST00000438323.2 |
interferon-induced protein 35 |
|
| chr12_-_121476959 Show fit | 1.74 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr19_+_57631411 Show fit | 1.69 |
ENST00000254181.4
ENST00000600940.1 |
ubiquitin specific peptidase 29 |
|
| chr12_-_121477039 Show fit | 1.65 |
ENST00000257570.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr2_-_32390801 Show fit | 1.61 |
ENST00000608489.1
|
RP11-563N4.1 |
|
| chr11_-_64764435 Show fit | 1.61 |
ENST00000534177.1
ENST00000301887.4 |
basic leucine zipper transcription factor, ATF-like 2 |
|
| chr17_+_58018269 Show fit | 1.56 |
ENST00000591035.1
|
Uncharacterized protein |
|
| chr19_-_44160768 Show fit | 1.55 |
ENST00000593447.1
|
plasminogen activator, urokinase receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.2 | 7.0 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 4.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 4.0 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 3.4 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 3.2 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 2.1 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.1 | 2.1 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 1.7 | GO:0071725 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.1 | 1.5 | GO:1904180 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.6 | GO:0000243 | commitment complex(GO:0000243) |
| 0.2 | 3.2 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 3.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.8 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 2.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 2.2 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 2.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 1.9 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 1.9 | GO:0005840 | ribosome(GO:0005840) |
| 0.1 | 1.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.4 | 4.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 3.3 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.5 | 3.2 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.0 | 3.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.7 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 2.5 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 2.0 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 1.8 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 1.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.0 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.0 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 3.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 2.5 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.7 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 1.7 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.2 | 1.6 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 1.6 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |