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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for PAX6
Z-value: 1.27
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Transcription factors associated with PAX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX6 | hg19_v2_chr11_-_31839488_31839515 | 0.91 | 9.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_121476959 Show fit | 1.75 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr1_+_79115503 Show fit | 1.58 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
interferon-induced protein 44 |
|
| chr12_+_113354341 Show fit | 1.53 |
ENST00000553152.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr10_+_91092241 Show fit | 1.44 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr12_-_10007448 Show fit | 0.89 |
ENST00000538152.1
|
C-type lectin domain family 2, member B |
|
| chr12_-_78934441 Show fit | 0.87 |
ENST00000546865.1
ENST00000547089.1 |
RP11-171L9.1 |
|
| chr19_-_36019123 Show fit | 0.61 |
ENST00000588674.1
ENST00000452271.2 ENST00000518157.1 |
suprabasin |
|
| chr1_+_223354486 Show fit | 0.59 |
ENST00000446145.1
|
RP11-239E10.3 |
|
| chr8_-_19614810 Show fit | 0.57 |
ENST00000524213.1
|
chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
|
| chr20_+_48807351 Show fit | 0.55 |
ENST00000303004.3
|
CCAAT/enhancer binding protein (C/EBP), beta |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 1.4 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.1 | 1.2 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.2 | 0.9 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.1 | 0.9 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.0 | 0.6 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.0 | 0.6 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.6 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.0 | 0.5 | GO:0042104 | positive regulation of activated T cell proliferation(GO:0042104) |
| 0.0 | 0.5 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.5 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.2 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.0 | 0.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 0.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.2 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.0 | 0.2 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 0.2 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 1.0 | GO:0050694 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.1 | 0.9 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.0 | 0.8 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 0.6 | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.0 | 0.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.4 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.3 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.3 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.3 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.2 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.1 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |