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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for PATZ1_KLF4
Z-value: 1.96
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Transcription factors associated with PATZ1_KLF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PATZ1 | hg19_v2_chr22_-_31742218_31742350 | -0.20 | 8.0e-01 | Click! |
| KLF4 | hg19_v2_chr9_-_110251836_110251927 | -0.15 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PATZ1_KLF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 6.9 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 5.3 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.6 | 4.9 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.0 | 4.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 3.8 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.1 | 3.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 3.5 | GO:0060180 | female mating behavior(GO:0060180) |
| 0.3 | 3.4 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.1 | 3.4 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 9.2 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.0 | 6.8 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.1 | 6.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 5.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 4.7 | GO:0031968 | organelle outer membrane(GO:0031968) |
| 0.0 | 4.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 4.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 4.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 4.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 8.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 6.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.7 | 5.2 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.1 | 4.8 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.0 | 4.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 4.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 4.4 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 4.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 4.0 | GO:0004645 | phosphorylase activity(GO:0004645) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 7.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 6.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 6.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 5.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 4.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 4.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 7.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 6.8 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 5.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 5.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 5.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 4.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 4.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.8 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 3.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |