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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for OTX2_CRX
Z-value: 1.04
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Transcription factors associated with OTX2_CRX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CRX | hg19_v2_chr19_+_48325097_48325211 | 0.40 | 6.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_86999516 Show fit | 0.77 |
ENST00000521564.1
|
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 |
|
| chr17_-_4689649 Show fit | 0.76 |
ENST00000441199.2
ENST00000416307.2 |
vitelline membrane outer layer 1 homolog (chicken) |
|
| chr6_+_130339710 Show fit | 0.70 |
ENST00000526087.1
ENST00000533560.1 ENST00000361794.2 |
l(3)mbt-like 3 (Drosophila) |
|
| chr1_+_207277632 Show fit | 0.61 |
ENST00000421786.1
|
complement component 4 binding protein, alpha |
|
| chr17_+_4643337 Show fit | 0.61 |
ENST00000592813.1
|
zinc finger, MYND-type containing 15 |
|
| chr14_-_95236551 Show fit | 0.58 |
ENST00000238558.3
|
goosecoid homeobox |
|
| chr17_-_4643161 Show fit | 0.53 |
ENST00000574412.1
|
chemokine (C-X-C motif) ligand 16 |
|
| chr14_-_22005062 Show fit | 0.53 |
ENST00000317492.5
|
spalt-like transcription factor 2 |
|
| chr15_+_44092784 Show fit | 0.51 |
ENST00000458412.1
|
huntingtin interacting protein K |
|
| chr6_+_34433844 Show fit | 0.51 |
ENST00000244458.2
ENST00000374043.2 |
protein kinase C and casein kinase substrate in neurons 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of OTX2_CRX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.0 | 0.8 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.7 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 0.6 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.6 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.6 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.1 | 0.5 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.0 | 0.4 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
| 0.0 | 0.4 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 0.4 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.8 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.5 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.4 | GO:0033177 | proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) |
| 0.0 | 0.3 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 0.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 0.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.1 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 0.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 0.4 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) |
| 0.0 | 0.4 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 0.3 | GO:0010858 | calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.0 | 0.3 | GO:0045029 | uridine nucleotide receptor activity(GO:0015065) UDP-activated nucleotide receptor activity(GO:0045029) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553) |
| 0.0 | 0.3 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.0 | 0.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.3 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 0.2 | GO:0030366 | molybdopterin synthase activity(GO:0030366) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.1 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 0.4 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.3 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |