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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for OTX1
Z-value: 1.36
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Transcription factors associated with OTX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OTX1 | hg19_v2_chr2_+_63277927_63277938 | 0.42 | 5.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_67968793 Show fit | 2.29 |
ENST00000417488.1
|
Protein LOC644249 |
|
| chr7_+_30589829 Show fit | 1.76 |
ENST00000579437.1
|
RP4-777O23.1 |
|
| chr7_-_91509972 Show fit | 1.14 |
ENST00000425936.1
|
mitochondrial transcription termination factor |
|
| chr1_+_241695424 Show fit | 0.99 |
ENST00000366558.3
ENST00000366559.4 |
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
|
| chr1_+_241695670 Show fit | 0.95 |
ENST00000366557.4
|
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
|
| chr2_-_160654745 Show fit | 0.73 |
ENST00000259053.4
ENST00000429078.2 |
CD302 molecule |
|
| chr12_+_100594557 Show fit | 0.71 |
ENST00000546902.1
ENST00000552376.1 ENST00000551617.1 |
ARP6 actin-related protein 6 homolog (yeast) |
|
| chr4_-_122744998 Show fit | 0.69 |
ENST00000274026.5
|
cyclin A2 |
|
| chr1_+_229440129 Show fit | 0.64 |
ENST00000366688.3
|
S-phase response (cyclin related) |
|
| chr6_+_26204825 Show fit | 0.63 |
ENST00000360441.4
|
histone cluster 1, H4e |
Network of associatons between targets according to the STRING database.
First level regulatory network of OTX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.1 | 0.9 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.0 | 0.8 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.0 | 0.8 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.2 | 0.7 | GO:0071373 | cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373) |
| 0.1 | 0.6 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.0 | 0.6 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.2 | 0.5 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.1 | 0.5 | GO:0036414 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.1 | 0.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:1990357 | terminal web(GO:1990357) |
| 0.2 | 0.7 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.0 | 0.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.4 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.0 | 0.4 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.3 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.3 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 0.2 | GO:1990923 | PET complex(GO:1990923) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.3 | 0.8 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.1 | 0.8 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 0.1 | 0.6 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.1 | 0.6 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.2 | 0.5 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.1 | 0.5 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.0 | 0.5 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.4 | GO:0030911 | TPR domain binding(GO:0030911) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.4 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.0 | 1.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.7 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |