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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for OLIG2_NEUROD1_ATOH1
Z-value: 1.21
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Transcription factors associated with OLIG2_NEUROD1_ATOH1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OLIG2 | hg19_v2_chr21_+_34398153_34398250 | -0.70 | 3.0e-01 | Click! |
| NEUROD1 | hg19_v2_chr2_-_182545603_182545603 | -0.61 | 3.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_21905120 Show fit | 0.91 |
ENST00000331505.5
|
RIMS binding protein 3C |
|
| chr8_-_135522425 Show fit | 0.79 |
ENST00000521673.1
|
zinc finger and AT hook domain containing |
|
| chr8_-_123706338 Show fit | 0.68 |
ENST00000521608.1
|
long intergenic non-protein coding RNA 1151 |
|
| chr19_-_38743878 Show fit | 0.64 |
ENST00000587515.1
|
protein phosphatase 1, regulatory (inhibitor) subunit 14A |
|
| chr5_+_71475449 Show fit | 0.62 |
ENST00000504492.1
|
microtubule-associated protein 1B |
|
| chr2_-_154335300 Show fit | 0.62 |
ENST00000325926.3
|
reprimo, TP53 dependent G2 arrest mediator candidate |
|
| chr6_-_26250835 Show fit | 0.57 |
ENST00000446824.2
|
histone cluster 1, H3f |
|
| chr12_-_58145889 Show fit | 0.53 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr4_-_24914576 Show fit | 0.49 |
ENST00000502801.1
ENST00000428116.2 |
coiled-coil domain containing 149 |
|
| chrX_+_118108571 Show fit | 0.48 |
ENST00000304778.7
|
LON peptidase N-terminal domain and ring finger 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG2_NEUROD1_ATOH1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.0 | 0.8 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.0 | 0.7 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.2 | 0.5 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.1 | 0.5 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.0 | 0.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 0.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.4 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.4 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 0.4 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 0.5 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.4 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.3 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.3 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 0.2 | GO:0000814 | ESCRT II complex(GO:0000814) |
| 0.0 | 0.2 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.0 | 0.2 | GO:0000801 | central element(GO:0000801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.9 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.3 | 0.8 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.0 | 0.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.5 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 0.4 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.1 | 0.4 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 0.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 0.3 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.3 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.2 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |