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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NRF1
Z-value: 3.84
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | 0.19 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.3 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.1 | 3.2 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.0 | 3.2 | GO:0007040 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.1 | 3.0 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 2.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.1 | 2.8 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.5 | 2.7 | GO:1903613 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.1 | 2.6 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 2.4 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.3 | 2.3 | GO:0071494 | cellular response to UV-C(GO:0071494) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.3 | 3.1 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.2 | 3.0 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 2.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 2.6 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 2.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.5 | 2.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.2 | 2.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.2 | 2.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 2.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 3.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 3.3 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 3.3 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.1 | 3.1 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 2.9 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 2.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 2.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 2.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 4.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.8 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 4.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 3.2 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 3.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.0 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 2.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 2.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.3 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.1 | 2.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |