ISMARA results: NR5A2

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NR5A2

Z-value: 1.27

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Transcription factors associated with NR5A2

Gene Symbol	Gene ID	Gene Info
NR5A2 Ensembl NCBI GeneCards UniProt	ENSG00000116833.9	nuclear receptor subfamily 5 group A member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR5A2	hg19_v2_chr1_+_200011711_200011752	-0.75	2.5e-01	Click!

Activity profile of NR5A2 motif

Sorted Z-values of NR5A2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_42624050 Show fit	0.86	ENST00000601185.1	AC020629.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr14_+_21492331 Show fit	0.85	ENST00000533984.1 ENST00000532213.2	AL161668.5 Ensembl NCBI GeneCards UniProt Show fit	AL161668.5
chr21_+_33671264 Show fit	0.80	ENST00000339944.4	MRAP Ensembl NCBI GeneCards UniProt Show fit	melanocortin 2 receptor accessory protein
chr5_+_52285144 Show fit	0.78	ENST00000296585.5	ITGA2 Ensembl NCBI GeneCards UniProt Show fit	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr16_-_67224002 Show fit	0.78	ENST00000563889.1 ENST00000564418.1 ENST00000545725.2 ENST00000314586.6	EXOC3L1 Ensembl NCBI GeneCards UniProt Show fit	exocyst complex component 3-like 1
chr17_+_74372662 Show fit	0.77	ENST00000591651.1 ENST00000545180.1	SPHK1 Ensembl NCBI GeneCards UniProt Show fit	sphingosine kinase 1
chr20_-_44455976 Show fit	0.77	ENST00000372555.3	TNNC2 Ensembl NCBI GeneCards UniProt Show fit	troponin C type 2 (fast)
chr17_-_73844722 Show fit	0.73	ENST00000586257.1	WBP2 Ensembl NCBI GeneCards UniProt Show fit	WW domain binding protein 2
chr8_+_74271144 Show fit	0.72	ENST00000519134.1 ENST00000518355.1	RP11-434I12.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-434I12.3
chr12_+_56732658 Show fit	0.68	ENST00000228534.4	IL23A Ensembl NCBI GeneCards UniProt Show fit	interleukin 23, alpha subunit p19

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR5A2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.9	GO:0006218	uridine catabolic process(GO:0006218)
0.0	1.5	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	1.5	GO:0015701	bicarbonate transport(GO:0015701)
0.0	1.4	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	1.3	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	1.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.9	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3	0.8	GO:0033341	regulation of collagen binding(GO:0033341)
0.3	0.8	GO:0046521	sphingoid catabolic process(GO:0046521)
0.0	0.8	GO:0006705	mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)

Showing 1 to 10 of 198 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0000145	exocyst(GO:0000145)
0.0	1.2	GO:0036126	sperm flagellum(GO:0036126)
0.1	0.9	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.9	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1	0.8	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.1	0.8	GO:0005861	troponin complex(GO:0005861)
0.0	0.8	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.8	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.7	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.6	GO:0044530	supraspliceosomal complex(GO:0044530)

Showing 1 to 10 of 71 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.9	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.1	1.6	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	1.6	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.4	1.3	GO:0070996	corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996)
0.0	1.1	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	1.0	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	1.0	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.9	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3	0.8	GO:0033867	Fas-activated serine/threonine kinase activity(GO:0033867)
0.1	0.8	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)

Showing 1 to 10 of 126 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.4	PID RAS PATHWAY	Regulation of Ras family activation
0.9	PID S1P S1P1 PATHWAY	S1P1 pathway
0.9	PID IL23 PATHWAY	IL23-mediated signaling events
0.7	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.7	PID TRAIL PATHWAY	TRAIL signaling pathway
0.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.5	PID IFNG PATHWAY	IFN-gamma pathway

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.9	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	1.8	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	1.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	1.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	1.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	1.0	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	1.0	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.8	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis

Showing 1 to 10 of 30 entries

Results for NR5A2

Z-value: 1.27

Motif logo

Transcription factors associated with NR5A2

Activity-expression correlation:

Activity profile of NR5A2 motif

Sorted Z-values of NR5A2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR5A2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: