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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NR4A1
Z-value: 1.54
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Transcription factors associated with NR4A1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A1 | hg19_v2_chr12_+_52450298_52450388 | -0.82 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_126409159 Show fit | 2.02 |
ENST00000607731.1
ENST00000535381.1 ENST00000296662.5 ENST00000509733.3 |
chromosome 5 open reading frame 63 |
|
| chr17_-_66287257 Show fit | 1.25 |
ENST00000327268.4
|
solute carrier family 16, member 6 |
|
| chr14_+_101295638 Show fit | 1.13 |
ENST00000523671.2
|
maternally expressed 3 (non-protein coding) |
|
| chr5_-_141703713 Show fit | 1.00 |
ENST00000511815.1
|
sprouty homolog 4 (Drosophila) |
|
| chr14_-_101295407 Show fit | 0.96 |
ENST00000596284.1
|
AL117190.2 |
|
| chr10_-_128359074 Show fit | 0.95 |
ENST00000544758.1
|
chromosome 10 open reading frame 90 |
|
| chr6_+_31895480 Show fit | 0.84 |
ENST00000418949.2
ENST00000383177.3 ENST00000477310.1 |
complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr6_+_31895467 Show fit | 0.83 |
ENST00000556679.1
ENST00000456570.1 |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr14_-_77495007 Show fit | 0.83 |
ENST00000238647.3
|
interferon regulatory factor 2 binding protein-like |
|
| chr5_+_73109339 Show fit | 0.69 |
ENST00000296799.4
|
Rho guanine nucleotide exchange factor (GEF) 28 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 1.0 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.1 | 0.9 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
| 0.1 | 0.8 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.1 | 0.7 | GO:0090646 | mitochondrial tRNA processing(GO:0090646) |
| 0.0 | 0.7 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.0 | 0.7 | GO:0002675 | positive regulation of acute inflammatory response(GO:0002675) |
| 0.2 | 0.5 | GO:0045362 | interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 0.5 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.1 | 0.5 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.1 | 0.5 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 0.4 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.0 | 0.4 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.0 | 0.3 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.2 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.0 | 0.2 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.2 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.2 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.1 | GO:0032389 | MutLalpha complex(GO:0032389) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 1.7 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.9 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 0.8 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.0 | 0.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.6 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.0 | 0.6 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 0.5 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.9 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.5 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.5 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |