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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NR2C1
Z-value: 1.13
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Transcription factors associated with NR2C1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2C1 | hg19_v2_chr12_-_95467267_95467350 | -0.55 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_124873357 Show fit | 1.47 |
ENST00000448614.1
|
nuclear receptor corepressor 2 |
|
| chr9_-_16253112 Show fit | 1.12 |
ENST00000380683.1
|
chromosome 9 open reading frame 92 |
|
| chr5_+_1801503 Show fit | 1.00 |
ENST00000274137.5
ENST00000469176.1 |
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) |
|
| chr19_-_49371711 Show fit | 1.00 |
ENST00000355496.5
ENST00000263265.6 |
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
|
| chr17_+_37821593 Show fit | 0.96 |
ENST00000578283.1
|
titin-cap |
|
| chr19_-_51289374 Show fit | 0.91 |
ENST00000563228.1
|
CTD-2568A17.1 |
|
| chr12_+_48499883 Show fit | 0.84 |
ENST00000546755.1
ENST00000549366.1 ENST00000552792.1 |
phosphofructokinase, muscle |
|
| chr7_+_100770328 Show fit | 0.83 |
ENST00000223095.4
ENST00000445463.2 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
| chr6_-_160147925 Show fit | 0.81 |
ENST00000535561.1
|
superoxide dismutase 2, mitochondrial |
|
| chr12_-_6665200 Show fit | 0.79 |
ENST00000336604.4
ENST00000396840.2 ENST00000356896.4 |
intermediate filament family orphan 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2C1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 1.6 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.5 | 1.5 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.3 | 1.0 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.3 | 0.8 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.1 | 0.8 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.1 | 0.5 | GO:0048205 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.1 | 0.5 | GO:2001293 | malonyl-CoA metabolic process(GO:2001293) |
| 0.0 | 0.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.5 | GO:0032060 | bleb assembly(GO:0032060) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.8 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.4 | GO:0045293 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.0 | 0.4 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.4 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.4 | GO:0005865 | striated muscle thin filament(GO:0005865) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 1.6 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 1.5 | GO:0005112 | Notch binding(GO:0005112) |
| 0.3 | 1.0 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 1.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.8 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.0 | 0.6 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.5 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.4 | GO:0035939 | microsatellite binding(GO:0035939) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.3 | REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| 0.0 | 1.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.5 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.4 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 0.4 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |