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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NR1I2
Z-value: 1.05
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Transcription factors associated with NR1I2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1I2 | hg19_v2_chr3_+_119499331_119499331 | 0.75 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_46035187 Show fit | 1.20 |
ENST00000300557.2
|
proline rich 15-like |
|
| chr1_+_229440129 Show fit | 1.12 |
ENST00000366688.3
|
S-phase response (cyclin related) |
|
| chr16_+_28874345 Show fit | 0.96 |
ENST00000566209.1
|
SH2B adaptor protein 1 |
|
| chr17_-_7082861 Show fit | 0.82 |
ENST00000269299.3
|
asialoglycoprotein receptor 1 |
|
| chr15_+_96875657 Show fit | 0.75 |
ENST00000559679.1
ENST00000394171.2 |
nuclear receptor subfamily 2, group F, member 2 |
|
| chr16_-_67427389 Show fit | 0.65 |
ENST00000562206.1
ENST00000290942.5 ENST00000393957.2 |
tubulin polymerization-promoting protein family member 3 |
|
| chr19_-_36304201 Show fit | 0.61 |
ENST00000301175.3
|
proline dehydrogenase (oxidase) 2 |
|
| chr1_-_12679171 Show fit | 0.61 |
ENST00000606790.1
|
RP11-474O21.5 |
|
| chr19_-_51289436 Show fit | 0.57 |
ENST00000562076.1
|
CTD-2568A17.1 |
|
| chr1_-_197036364 Show fit | 0.57 |
ENST00000367412.1
|
coagulation factor XIII, B polypeptide |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1I2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.1 | 1.1 | GO:1903027 | regulation of opsonization(GO:1903027) |
| 0.0 | 1.1 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 1.0 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.2 | 0.9 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.2 | 0.8 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.1 | 0.7 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.1 | 0.7 | GO:0071484 | cellular response to light intensity(GO:0071484) |
| 0.1 | 0.6 | GO:0010133 | proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) |
| 0.1 | 0.6 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.2 | 0.7 | GO:0031379 | RNA-directed RNA polymerase complex(GO:0031379) |
| 0.1 | 0.6 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.6 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 0.5 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.1 | 0.5 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 0.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.1 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.0 | 0.9 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.1 | 0.7 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.7 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.2 | 0.6 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.0 | 0.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 0.5 | GO:0031780 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996) |
| 0.1 | 0.5 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 0.5 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.3 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.2 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.2 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 0.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.6 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 0.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.5 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |