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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NR1H2
Z-value: 1.14
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Transcription factors associated with NR1H2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H2 | hg19_v2_chr19_+_50879705_50879775 | 0.72 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.9 | GO:1901569 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.0 | 1.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.3 | 1.3 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.0 | 1.0 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.2 | 0.9 | GO:2000097 | negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.0 | 0.9 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.1 | 0.8 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.1 | 0.7 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.1 | 0.6 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.2 | 0.5 | GO:0042245 | RNA repair(GO:0042245) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.5 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 0.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 0.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.5 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.5 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 0.3 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.0 | 0.3 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0052871 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.0 | 1.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 0.7 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.2 | 0.6 | GO:0034736 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.0 | 0.6 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.3 | 0.5 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.1 | 0.5 | GO:0002094 | polyprenyltransferase activity(GO:0002094) |
| 0.1 | 0.5 | GO:0035514 | DNA demethylase activity(GO:0035514) |
| 0.1 | 0.5 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 0.5 | GO:0004797 | thymidine kinase activity(GO:0004797) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.6 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.6 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.5 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.5 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.3 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |