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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NR0B1
Z-value: 1.23
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Transcription factors associated with NR0B1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR0B1 | hg19_v2_chrX_-_30326445_30326605 | 0.73 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_144679264 Show fit | 0.86 |
ENST00000531953.1
ENST00000526133.1 |
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) |
|
| chr18_+_29672573 Show fit | 0.76 |
ENST00000578107.1
ENST00000257190.5 ENST00000580499.1 |
ring finger protein 138, E3 ubiquitin protein ligase |
|
| chr16_+_2014993 Show fit | 0.72 |
ENST00000564014.1
|
small nucleolar RNA host gene 9 (non-protein coding) |
|
| chr3_-_123168551 Show fit | 0.72 |
ENST00000462833.1
|
adenylate cyclase 5 |
|
| chr8_-_42396721 Show fit | 0.69 |
ENST00000518384.1
|
solute carrier family 20 (phosphate transporter), member 2 |
|
| chr13_-_52027134 Show fit | 0.64 |
ENST00000311234.4
ENST00000425000.1 ENST00000463928.1 ENST00000442263.3 ENST00000398119.2 |
integrator complex subunit 6 |
|
| chr4_+_89300158 Show fit | 0.63 |
ENST00000502870.1
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr1_+_211433275 Show fit | 0.57 |
ENST00000367005.4
|
REST corepressor 3 |
|
| chr17_+_29421987 Show fit | 0.57 |
ENST00000431387.4
|
neurofibromin 1 |
|
| chr20_-_35807741 Show fit | 0.56 |
ENST00000434295.1
ENST00000441008.2 ENST00000400441.3 ENST00000343811.4 |
maestro heat-like repeat family member 8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR0B1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 1.2 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 1.1 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.3 | 0.9 | GO:0000961 | negative regulation of mitochondrial RNA catabolic process(GO:0000961) |
| 0.1 | 0.9 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.3 | 0.8 | GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission(GO:0061534) |
| 0.2 | 0.7 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.7 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.0 | 0.7 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 0.7 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.1 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.1 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 0.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.6 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 0.6 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 0.5 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 0.5 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 1.1 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.9 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.8 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 0.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 0.7 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 0.7 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.1 | 0.7 | GO:0038051 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 0.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.3 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |