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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NKX6-2
Z-value: 1.36
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Transcription factors associated with NKX6-2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_74686314 Show fit | 1.28 |
ENST00000551210.1
ENST00000515416.2 ENST00000549905.1 |
RP11-81H3.2 |
|
| chr1_+_229440129 Show fit | 1.13 |
ENST00000366688.3
|
S-phase response (cyclin related) |
|
| chr2_-_228244013 Show fit | 1.13 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
|
| chr5_+_31193847 Show fit | 1.06 |
ENST00000514738.1
ENST00000265071.2 |
cadherin 6, type 2, K-cadherin (fetal kidney) |
|
| chr1_-_200379180 Show fit | 0.94 |
ENST00000294740.3
|
zinc finger protein 281 |
|
| chr1_+_85527987 Show fit | 0.83 |
ENST00000326813.8
ENST00000294664.6 ENST00000528899.1 |
WD repeat domain 63 |
|
| chr16_+_53483983 Show fit | 0.81 |
ENST00000544545.1
|
retinoblastoma-like 2 (p130) |
|
| chr12_-_122241812 Show fit | 0.79 |
ENST00000538335.1
|
AC084018.1 |
|
| chr17_-_57232596 Show fit | 0.76 |
ENST00000581068.1
ENST00000330137.7 |
spindle and kinetochore associated complex subunit 2 |
|
| chr2_+_179318295 Show fit | 0.76 |
ENST00000442710.1
|
deafness, autosomal recessive 59 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX6-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.0 | 1.3 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.2 | 0.9 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.2 | 0.7 | GO:0060152 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 0.2 | 0.7 | GO:0042000 | translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836) |
| 0.1 | 0.7 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.0 | 0.7 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.1 | 0.6 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 0.1 | 0.6 | GO:0033685 | negative regulation of luteinizing hormone secretion(GO:0033685) |
| 0.1 | 0.6 | GO:0009441 | glycolate metabolic process(GO:0009441) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.2 | 0.7 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.7 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.7 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.6 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.5 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 0.5 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.0 | 0.5 | GO:0030008 | TRAPP complex(GO:0030008) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 0.6 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
| 0.1 | 0.6 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.1 | 0.6 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 0.0 | 0.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.5 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.5 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.5 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 0.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.2 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |