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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NKX2-5

Z-value: 0.80

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
NKX2-5
ENSG00000183072.9 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662197_1726622160.524.8e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_115567767 0.40 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_123717711 0.35 ENST00000537854.1
MPHOSPH9
M-phase phosphoprotein 9
chr1_+_150254936 0.33 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
C1orf51
chromosome 1 open reading frame 51
chr8_-_73793975 0.32 ENST00000523881.1
RP11-1145L24.1
RP11-1145L24.1
chr1_-_11115877 0.31 ENST00000490101.1
SRM
spermidine synthase
chr17_+_74261413 0.30 ENST00000587913.1
UBALD2
UBA-like domain containing 2
chr20_-_56285595 0.30 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr4_-_168155730 0.29 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_+_113354341 0.28 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr16_+_77233294 0.28 ENST00000378644.4
SYCE1L
synaptonemal complex central element protein 1-like
chr1_+_26606608 0.27 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr7_-_27224795 0.27 ENST00000006015.3
HOXA11
homeobox A11
chr7_-_99774945 0.26 ENST00000292377.2
GPC2
glypican 2
chr17_-_29641104 0.26 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr17_-_55911970 0.26 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr7_-_94953878 0.25 ENST00000222381.3
PON1
paraoxonase 1
chr4_+_81118647 0.23 ENST00000415738.2
PRDM8
PR domain containing 8
chr19_+_39926791 0.23 ENST00000594990.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr6_+_26273144 0.22 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr13_-_41240717 0.22 ENST00000379561.5
FOXO1
forkhead box O1
chr9_-_138393580 0.20 ENST00000371791.1
C9orf116
chromosome 9 open reading frame 116
chr6_-_41715128 0.20 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chr5_-_138730817 0.20 ENST00000434752.2
PROB1
proline-rich basic protein 1
chr9_-_25678856 0.20 ENST00000358022.3
TUSC1
tumor suppressor candidate 1
chr7_-_107883678 0.20 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr18_+_42260059 0.20 ENST00000426838.4
SETBP1
SET binding protein 1
chr10_-_49813090 0.19 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr19_-_5680891 0.19 ENST00000309324.4
C19orf70
chromosome 19 open reading frame 70
chr3_-_194072019 0.19 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chr7_+_129007964 0.18 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr8_+_9009296 0.18 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chrX_-_14047996 0.18 ENST00000380523.4
ENST00000398355.3
GEMIN8
gem (nuclear organelle) associated protein 8
chr1_-_202858227 0.18 ENST00000367262.3
RABIF
RAB interacting factor
chr15_+_42696954 0.18 ENST00000337571.4
ENST00000569136.1
CAPN3
calpain 3, (p94)
chr14_+_78227105 0.17 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chrX_-_55057403 0.17 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2
aminolevulinate, delta-, synthase 2
chr21_+_44313375 0.17 ENST00000354250.2
ENST00000340344.4
NDUFV3
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
chr9_+_35906176 0.17 ENST00000354323.2
HRCT1
histidine rich carboxyl terminus 1
chr18_+_42277095 0.16 ENST00000591940.1
SETBP1
SET binding protein 1
chr16_-_30134524 0.16 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3
mitogen-activated protein kinase 3
chr7_-_27224842 0.16 ENST00000517402.1
HOXA11
homeobox A11
chr17_+_74261277 0.16 ENST00000327490.6
UBALD2
UBA-like domain containing 2
chr4_-_168155577 0.16 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr14_+_105927191 0.15 ENST00000550551.1
MTA1
metastasis associated 1
chr17_-_7493390 0.15 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chr18_+_61575200 0.15 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr4_+_108746282 0.14 ENST00000503862.1
SGMS2
sphingomyelin synthase 2
chr17_-_29641084 0.14 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_-_11685345 0.14 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr7_-_122339162 0.14 ENST00000340112.2
RNF133
ring finger protein 133
chr19_+_14672755 0.14 ENST00000594545.1
TECR
trans-2,3-enoyl-CoA reductase
chr15_+_42697018 0.13 ENST00000397204.4
CAPN3
calpain 3, (p94)
chr16_-_30134266 0.13 ENST00000484663.1
ENST00000478356.1
MAPK3
mitogen-activated protein kinase 3
chr2_+_219646462 0.13 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr7_-_128415844 0.13 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr4_-_2264015 0.13 ENST00000337190.2
MXD4
MAX dimerization protein 4
chrX_-_49041242 0.13 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr5_+_75699040 0.13 ENST00000274364.6
IQGAP2
IQ motif containing GTPase activating protein 2
chr20_+_55841819 0.12 ENST00000412321.1
ENST00000426580.1
RP4-813D12.3
RP4-813D12.3
chr3_-_123710893 0.12 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr4_+_110769258 0.12 ENST00000594814.1
LRIT3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr2_-_27545431 0.12 ENST00000233545.2
MPV17
MpV17 mitochondrial inner membrane protein
chr1_+_76540386 0.12 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr22_-_38577731 0.12 ENST00000335539.3
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr10_+_86184676 0.12 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr10_-_27529486 0.11 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr7_-_92146729 0.11 ENST00000541751.1
PEX1
peroxisomal biogenesis factor 1
chr10_-_128359074 0.11 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr6_-_134373732 0.11 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr22_-_38577782 0.11 ENST00000430886.1
ENST00000332509.3
ENST00000447598.2
ENST00000435484.1
ENST00000402064.1
ENST00000436218.1
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr9_+_17579084 0.11 ENST00000380607.4
SH3GL2
SH3-domain GRB2-like 2
chr3_+_23847394 0.11 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr5_+_74062806 0.10 ENST00000296802.5
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr1_-_149982624 0.10 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr2_+_201997492 0.10 ENST00000494258.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr12_-_123717643 0.10 ENST00000541437.1
ENST00000606320.1
MPHOSPH9
M-phase phosphoprotein 9
chr12_+_93772402 0.10 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr8_-_49833978 0.10 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr11_-_118436606 0.10 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr5_+_122110691 0.10 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr1_+_161676739 0.09 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
FCRLA
Fc receptor-like A
chr17_-_56621665 0.09 ENST00000321691.3
C17orf47
chromosome 17 open reading frame 47
chr6_+_31916733 0.09 ENST00000483004.1
CFB
complement factor B
chr8_+_132916318 0.09 ENST00000254624.5
ENST00000522709.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr6_-_94129244 0.09 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr12_-_50222187 0.09 ENST00000335999.6
NCKAP5L
NCK-associated protein 5-like
chr8_-_10588010 0.09 ENST00000304501.1
SOX7
SRY (sex determining region Y)-box 7
chr17_-_3500392 0.08 ENST00000571088.1
ENST00000174621.6
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr12_+_14518598 0.08 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr2_-_201936302 0.08 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr7_-_38969150 0.08 ENST00000418457.2
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr6_+_33378738 0.08 ENST00000374512.3
ENST00000374516.3
PHF1
PHD finger protein 1
chr8_-_49834299 0.08 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr12_-_371994 0.07 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr1_+_207494853 0.07 ENST00000367064.3
ENST00000367063.2
ENST00000391921.4
ENST00000367067.4
ENST00000314754.8
ENST00000367065.5
ENST00000391920.4
ENST00000367062.4
ENST00000343420.6
CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr17_-_46667594 0.07 ENST00000476342.1
ENST00000460160.1
ENST00000472863.1
HOXB3
homeobox B3
chr7_-_81399355 0.07 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_+_64879317 0.07 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr2_-_85895295 0.07 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr7_-_81399329 0.07 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_-_113160826 0.07 ENST00000538187.1
ENST00000369664.1
ST7L
suppression of tumorigenicity 7 like
chr8_+_145729465 0.07 ENST00000394955.2
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr3_+_125687987 0.06 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chrX_+_86772787 0.06 ENST00000373114.4
KLHL4
kelch-like family member 4
chrX_+_40944871 0.06 ENST00000378308.2
ENST00000324545.8
USP9X
ubiquitin specific peptidase 9, X-linked
chr8_-_72459885 0.06 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr14_+_64565442 0.06 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr5_+_134181625 0.06 ENST00000394976.3
C5orf24
chromosome 5 open reading frame 24
chr5_-_74062867 0.06 ENST00000509097.1
GFM2
G elongation factor, mitochondrial 2
chr11_+_94277017 0.06 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr2_+_136289030 0.06 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr7_-_81399287 0.06 ENST00000354224.6
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr15_+_81589254 0.06 ENST00000394652.2
IL16
interleukin 16
chr16_+_69458537 0.06 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr10_-_99531709 0.06 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr22_-_29137771 0.06 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr4_+_156680518 0.06 ENST00000513437.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr1_+_161676983 0.05 ENST00000367957.2
FCRLA
Fc receptor-like A
chr1_+_100817262 0.05 ENST00000455467.1
CDC14A
cell division cycle 14A
chr6_-_112115074 0.05 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr15_-_42840961 0.05 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr4_-_168155700 0.05 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr7_-_81399411 0.05 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr22_-_50524298 0.05 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr16_+_8814563 0.05 ENST00000425191.2
ENST00000569156.1
ABAT
4-aminobutyrate aminotransferase
chr14_-_75179774 0.05 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr16_-_70729496 0.05 ENST00000567648.1
VAC14
Vac14 homolog (S. cerevisiae)
chr1_-_23520755 0.05 ENST00000314113.3
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr20_+_57226284 0.05 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
STX16
syntaxin 16
chr14_+_81421861 0.05 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr10_+_111967345 0.05 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr2_-_180610767 0.05 ENST00000409343.1
ZNF385B
zinc finger protein 385B
chr15_-_60683326 0.05 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2
annexin A2
chr17_+_29421987 0.05 ENST00000431387.4
NF1
neurofibromin 1
chr6_+_30297306 0.05 ENST00000420746.1
ENST00000513556.1
TRIM39
TRIM39-RPP21
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr1_-_36947120 0.05 ENST00000361632.4
CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr22_-_50523760 0.05 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr16_+_765092 0.05 ENST00000568223.2
METRN
meteorin, glial cell differentiation regulator
chr15_+_74421961 0.05 ENST00000565159.1
ENST00000567206.1
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_+_14547632 0.05 ENST00000218075.4
GLRA2
glycine receptor, alpha 2
chr16_-_30134441 0.05 ENST00000395200.1
MAPK3
mitogen-activated protein kinase 3
chr2_+_201936458 0.05 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr13_+_109248500 0.04 ENST00000356711.2
MYO16
myosin XVI
chr5_+_34685805 0.04 ENST00000508315.1
RAI14
retinoic acid induced 14
chr10_+_133753533 0.04 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr1_+_202431859 0.04 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr16_+_57769635 0.04 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr1_-_115259337 0.04 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr16_-_3149278 0.04 ENST00000575108.1
ENST00000576483.1
ENST00000538082.2
ENST00000576985.1
ZSCAN10
zinc finger and SCAN domain containing 10
chr17_-_40169429 0.04 ENST00000316603.7
ENST00000588641.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr17_-_8279977 0.04 ENST00000396267.1
KRBA2
KRAB-A domain containing 2
chr11_+_18417813 0.04 ENST00000540430.1
ENST00000379412.5
LDHA
lactate dehydrogenase A
chr6_+_109169591 0.04 ENST00000368972.3
ENST00000392644.4
ARMC2
armadillo repeat containing 2
chr8_+_133879193 0.04 ENST00000377869.1
ENST00000220616.4
TG
thyroglobulin
chr10_+_79626633 0.04 ENST00000372387.1
AL391421.1
Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964
chr14_+_81421355 0.04 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr20_-_271009 0.04 ENST00000382369.5
C20orf96
chromosome 20 open reading frame 96
chr6_-_112115103 0.04 ENST00000462598.3
FYN
FYN oncogene related to SRC, FGR, YES
chr11_-_118436707 0.03 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr4_-_168155417 0.03 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chrX_-_13835147 0.03 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr11_-_108464465 0.03 ENST00000525344.1
EXPH5
exophilin 5
chr15_+_78799948 0.03 ENST00000566332.1
HYKK
hydroxylysine kinase
chrX_-_154299501 0.03 ENST00000369476.3
ENST00000369484.3
MTCP1
CMC4
mature T-cell proliferation 1
C-x(9)-C motif containing 4
chrX_-_49965663 0.03 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4
chr17_+_40811283 0.03 ENST00000251412.7
TUBG2
tubulin, gamma 2
chr19_+_5681153 0.03 ENST00000579559.1
ENST00000577222.1
HSD11B1L
RPL36
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr19_-_5680499 0.03 ENST00000587589.1
C19orf70
chromosome 19 open reading frame 70
chr4_-_74853897 0.03 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr20_+_57226841 0.03 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr17_+_58755184 0.02 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr1_+_170115142 0.02 ENST00000439373.2
METTL11B
methyltransferase like 11B
chr11_+_17756279 0.02 ENST00000265969.6
KCNC1
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr17_-_13505219 0.02 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr7_-_81399438 0.02 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_-_160040038 0.02 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr18_-_13915530 0.02 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr17_-_40169659 0.02 ENST00000457167.4
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr8_-_120651020 0.02 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr1_-_55352834 0.02 ENST00000371269.3
DHCR24
24-dehydrocholesterol reductase
chr1_+_159796534 0.02 ENST00000289707.5
SLAMF8
SLAM family member 8
chr12_-_53097247 0.02 ENST00000341809.3
ENST00000537195.1
KRT77
keratin 77
chr3_+_45984947 0.02 ENST00000304552.4
CXCR6
chemokine (C-X-C motif) receptor 6
chr1_+_56880606 0.02 ENST00000451914.1
RP4-710M16.2
RP4-710M16.2
chr17_+_45973516 0.02 ENST00000376741.4
SP2
Sp2 transcription factor
chr15_-_74726283 0.02 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr11_-_18813110 0.02 ENST00000396168.1
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr1_+_154301264 0.01 ENST00000341822.2
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr11_+_120973375 0.01 ENST00000264037.2
TECTA
tectorin alpha
chr12_+_111051832 0.01 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr6_-_27279949 0.01 ENST00000444565.1
ENST00000377451.2
POM121L2
POM121 transmembrane nucleoporin-like 2
chr1_+_203765437 0.01 ENST00000550078.1
ZBED6
zinc finger, BED-type containing 6
chr19_-_45873642 0.01 ENST00000485403.2
ENST00000586856.1
ENST00000586131.1
ENST00000391940.4
ENST00000221481.6
ENST00000391944.3
ENST00000391945.4
ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2
chr3_-_187388173 0.01 ENST00000287641.3
SST
somatostatin
chr1_-_207143802 0.01 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr17_+_66521936 0.01 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr4_+_144354644 0.01 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr11_+_18417948 0.01 ENST00000542179.1
LDHA
lactate dehydrogenase A
chrX_+_71353499 0.01 ENST00000373677.1
NHSL2
NHS-like 2
chr9_+_118950325 0.01 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2000657 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.1 0.2 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.1 0.2 GO:0002760 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 0.4 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:1902617 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) response to fluoride(GO:1902617)
0.0 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.0 0.1 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.2 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.0 0.2 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.4 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.0 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.0 GO:0044035 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032044 DSIF complex(GO:0032044)
0.0 0.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 0.2 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 0.2 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.0 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.0 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.5 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines