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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NKX2-2
Z-value: 1.03
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Transcription factors associated with NKX2-2
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.1 | 0.9 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 0.9 | GO:0030238 | male sex determination(GO:0030238) |
| 0.0 | 0.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 0.7 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.2 | 0.6 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 0.6 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.2 | 0.5 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.1 | 0.5 | GO:0010966 | regulation of phosphate transport(GO:0010966) regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369) |
| 0.0 | 0.5 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 0.9 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.6 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 0.4 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.0 | 0.4 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.3 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.2 | GO:0098844 | postsynaptic endocytic zone(GO:0098843) postsynaptic endocytic zone membrane(GO:0098844) |
| 0.0 | 0.2 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 0.9 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.2 | 0.6 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.0 | 0.6 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.5 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.0 | 0.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.5 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 0.4 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.0 | 0.4 | GO:0050308 | carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 0.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.5 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |