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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NKX2-2

Z-value: 1.03

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.5 NK2 homeobox 2

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_30326445 0.93 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr12_-_102591604 0.75 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr1_+_241695424 0.73 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr11_-_8892900 0.71 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chrY_+_15418467 0.69 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr1_+_241695670 0.67 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_-_121379739 0.55 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr7_+_37723450 0.52 ENST00000447769.1
GPR141
G protein-coupled receptor 141
chr12_-_4488872 0.51 ENST00000237837.1
FGF23
fibroblast growth factor 23
chr12_-_112614506 0.48 ENST00000548588.2
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4
chr7_-_84121858 0.47 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr5_+_82767487 0.46 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr4_+_155484103 0.46 ENST00000302068.4
FGB
fibrinogen beta chain
chr15_+_58702742 0.45 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr6_-_73935163 0.45 ENST00000370388.3
KHDC1L
KH homology domain containing 1-like
chr4_+_155484155 0.45 ENST00000509493.1
FGB
fibrinogen beta chain
chr13_-_67802549 0.44 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr8_+_22414182 0.41 ENST00000524057.1
SORBS3
sorbin and SH3 domain containing 3
chr4_-_110723335 0.41 ENST00000394634.2
CFI
complement factor I
chr2_-_36779411 0.40 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr1_-_45253377 0.39 ENST00000372207.3
BEST4
bestrophin 4
chr12_+_14572070 0.39 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr8_-_102181718 0.38 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chr17_+_42015654 0.38 ENST00000565120.1
RP11-527L4.2
Uncharacterized protein
chr1_+_211433275 0.37 ENST00000367005.4
RCOR3
REST corepressor 3
chr19_-_17366257 0.37 ENST00000594059.1
AC010646.3
Uncharacterized protein
chr21_+_17214724 0.37 ENST00000449491.1
USP25
ubiquitin specific peptidase 25
chr15_-_38519066 0.37 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr12_-_120315074 0.36 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr12_-_42631529 0.35 ENST00000548917.1
YAF2
YY1 associated factor 2
chr9_-_97356075 0.35 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr17_+_15604513 0.35 ENST00000481540.1
ZNF286A
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA.
chr18_+_3466248 0.34 ENST00000581029.1
ENST00000581442.1
ENST00000579007.1
RP11-838N2.4
RP11-838N2.4
chr5_+_82767583 0.34 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr1_+_104068312 0.33 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr8_+_71485681 0.33 ENST00000391684.1
AC120194.1
AC120194.1
chr8_-_95220775 0.32 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr9_-_99382065 0.32 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr1_-_182573514 0.31 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr16_-_21289627 0.31 ENST00000396023.2
ENST00000415987.2
CRYM
crystallin, mu
chr12_-_68696652 0.31 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr4_+_95679072 0.31 ENST00000515059.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr9_+_129097520 0.30 ENST00000436593.3
MVB12B
multivesicular body subunit 12B
chr10_+_32735030 0.30 ENST00000277657.6
ENST00000362006.5
CCDC7
coiled-coil domain containing 7
chr4_+_87928140 0.30 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr7_-_120497178 0.30 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr1_-_207095324 0.29 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr7_+_115862858 0.29 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chrX_+_123095546 0.28 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr1_+_104068562 0.28 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr6_-_33285505 0.28 ENST00000431845.2
ZBTB22
zinc finger and BTB domain containing 22
chr14_+_39734482 0.28 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE5
CTAGE family, member 5
chr13_-_86373536 0.27 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr9_+_92219919 0.27 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr15_+_100348193 0.27 ENST00000558188.1
CTD-2054N24.2
Uncharacterized protein
chr13_-_107220455 0.27 ENST00000400198.3
ARGLU1
arginine and glutamate rich 1
chr18_-_68004529 0.27 ENST00000578633.1
RP11-484N16.1
RP11-484N16.1
chr17_+_75315654 0.26 ENST00000590595.1
SEPT9
septin 9
chr3_+_189507432 0.26 ENST00000354600.5
TP63
tumor protein p63
chr4_+_80584903 0.26 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr12_-_371994 0.26 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr6_-_116833500 0.26 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr11_+_59705928 0.25 ENST00000398992.1
OOSP1
oocyte secreted protein 1
chr2_+_170655322 0.25 ENST00000260956.4
ENST00000417292.1
SSB
Sjogren syndrome antigen B (autoantigen La)
chr2_-_239198743 0.25 ENST00000440245.1
ENST00000431832.1
PER2
period circadian clock 2
chr5_+_75904950 0.25 ENST00000502745.1
IQGAP2
IQ motif containing GTPase activating protein 2
chr8_+_91233711 0.24 ENST00000523283.1
ENST00000517400.1
LINC00534
long intergenic non-protein coding RNA 534
chr10_-_27529486 0.24 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chrX_+_123095860 0.23 ENST00000428941.1
STAG2
stromal antigen 2
chr22_-_43567750 0.23 ENST00000494035.1
TTLL12
tubulin tyrosine ligase-like family, member 12
chr1_+_53480598 0.23 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr1_+_171810606 0.23 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chr3_+_189507460 0.23 ENST00000434928.1
TP63
tumor protein p63
chr2_-_70409953 0.23 ENST00000419381.1
C2orf42
chromosome 2 open reading frame 42
chrX_+_123095890 0.23 ENST00000435215.1
STAG2
stromal antigen 2
chr6_+_77484663 0.23 ENST00000607287.1
RP11-354K4.2
RP11-354K4.2
chr14_-_89878369 0.23 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr2_+_189157536 0.22 ENST00000409580.1
ENST00000409637.3
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr4_-_111563076 0.22 ENST00000354925.2
ENST00000511990.1
PITX2
paired-like homeodomain 2
chr21_+_17792672 0.22 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr9_-_39239171 0.22 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr1_+_104159999 0.22 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr14_-_50154921 0.22 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr12_-_106697974 0.22 ENST00000553039.1
CKAP4
cytoskeleton-associated protein 4
chr3_+_151591422 0.22 ENST00000362032.5
SUCNR1
succinate receptor 1
chr8_-_124749609 0.22 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr4_+_128802016 0.22 ENST00000270861.5
ENST00000515069.1
ENST00000513090.1
ENST00000507249.1
PLK4
polo-like kinase 4
chr10_-_112678692 0.21 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr7_+_23719749 0.21 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr2_-_75937994 0.21 ENST00000409857.3
ENST00000470503.1
ENST00000541687.1
ENST00000442309.1
GCFC2
GC-rich sequence DNA-binding factor 2
chr4_+_74269956 0.21 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr2_-_75938115 0.21 ENST00000321027.3
GCFC2
GC-rich sequence DNA-binding factor 2
chr3_+_98482175 0.21 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr1_-_75198940 0.21 ENST00000417775.1
CRYZ
crystallin, zeta (quinone reductase)
chr3_-_123339343 0.21 ENST00000578202.1
MYLK
myosin light chain kinase
chr1_+_84630053 0.20 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_17135016 0.20 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr17_-_3496171 0.20 ENST00000399756.4
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr7_-_84569561 0.20 ENST00000439105.1
AC074183.4
AC074183.4
chr8_+_110552831 0.19 ENST00000530629.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr4_+_56719782 0.19 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
EXOC1
exocyst complex component 1
chr10_+_63808970 0.19 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_510795 0.19 ENST00000412006.2
CCDC77
coiled-coil domain containing 77
chr9_-_85882145 0.19 ENST00000328788.1
FRMD3
FERM domain containing 3
chr1_-_26633480 0.19 ENST00000450041.1
UBXN11
UBX domain protein 11
chr5_+_35852797 0.19 ENST00000508941.1
IL7R
interleukin 7 receptor
chr9_+_91926103 0.19 ENST00000314355.6
CKS2
CDC28 protein kinase regulatory subunit 2
chr21_+_30968360 0.18 ENST00000333765.4
GRIK1-AS2
GRIK1 antisense RNA 2
chr3_-_122134882 0.18 ENST00000330689.4
WDR5B
WD repeat domain 5B
chr8_-_82644562 0.18 ENST00000520604.1
ENST00000521742.1
ENST00000520635.1
ZFAND1
zinc finger, AN1-type domain 1
chr5_-_68339648 0.18 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr7_-_17598506 0.18 ENST00000451792.1
AC017060.1
AC017060.1
chr1_-_115259337 0.18 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr15_+_36887069 0.17 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
C15orf41
chromosome 15 open reading frame 41
chr4_-_178169927 0.17 ENST00000512516.1
RP11-487E13.1
Uncharacterized protein
chr12_+_510742 0.17 ENST00000239830.4
CCDC77
coiled-coil domain containing 77
chr12_+_57998400 0.17 ENST00000548804.1
ENST00000550596.1
ENST00000551835.1
ENST00000549583.1
DTX3
deltex homolog 3 (Drosophila)
chrX_+_108779004 0.17 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr2_+_39103103 0.17 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
MORN2
MORN repeat containing 2
chr18_+_43684298 0.17 ENST00000282058.6
HAUS1
HAUS augmin-like complex, subunit 1
chr13_+_25875662 0.17 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
NUPL1
nucleoporin like 1
chr1_-_244006528 0.17 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr10_-_121296045 0.16 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr12_-_71551652 0.16 ENST00000546561.1
TSPAN8
tetraspanin 8
chr1_+_150898733 0.16 ENST00000525956.1
SETDB1
SET domain, bifurcated 1
chrX_-_70474499 0.16 ENST00000353904.2
ZMYM3
zinc finger, MYM-type 3
chr5_+_159848854 0.16 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
PTTG1
pituitary tumor-transforming 1
chr2_+_113299990 0.16 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr5_+_159848807 0.16 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr1_-_160231451 0.16 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr14_-_82000140 0.15 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chrX_-_70474910 0.15 ENST00000373988.1
ENST00000373998.1
ZMYM3
zinc finger, MYM-type 3
chr2_+_120436760 0.15 ENST00000445518.1
ENST00000409951.1
TMEM177
transmembrane protein 177
chr18_+_19668021 0.15 ENST00000579830.1
RP11-595B24.2
Uncharacterized protein
chr17_-_29624343 0.15 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr20_-_13765526 0.15 ENST00000202816.1
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr3_+_189507523 0.15 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr2_+_183582774 0.15 ENST00000537515.1
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr4_+_41937131 0.14 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr12_+_52056548 0.14 ENST00000545061.1
ENST00000355133.3
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr13_+_50656307 0.14 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr1_+_67395922 0.14 ENST00000401042.3
ENST00000355356.3
MIER1
mesoderm induction early response 1, transcriptional regulator
chr12_-_111926342 0.14 ENST00000389154.3
ATXN2
ataxin 2
chr15_+_56657613 0.14 ENST00000352903.2
ENST00000537232.1
ENST00000561221.2
ENST00000558083.2
TEX9
testis expressed 9
chr2_+_162087577 0.14 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chrX_-_70473957 0.14 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
ZMYM3
zinc finger, MYM-type 3
chr8_-_101719159 0.14 ENST00000520868.1
ENST00000522658.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr9_-_15510287 0.13 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chr18_+_29671812 0.13 ENST00000261593.3
ENST00000578914.1
RNF138
ring finger protein 138, E3 ubiquitin protein ligase
chr4_-_99578776 0.13 ENST00000515287.1
TSPAN5
tetraspanin 5
chr5_+_75904918 0.13 ENST00000514001.1
ENST00000396234.3
ENST00000509074.1
IQGAP2
IQ motif containing GTPase activating protein 2
chr12_-_28124903 0.13 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chrX_-_70474377 0.13 ENST00000373978.1
ENST00000373981.1
ZMYM3
zinc finger, MYM-type 3
chr14_-_100841930 0.13 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr1_+_61547894 0.13 ENST00000403491.3
NFIA
nuclear factor I/A
chr4_+_174818390 0.13 ENST00000509968.1
ENST00000512263.1
RP11-161D15.1
RP11-161D15.1
chr1_-_246670614 0.13 ENST00000403792.3
SMYD3
SET and MYND domain containing 3
chr2_-_55276320 0.13 ENST00000357376.3
RTN4
reticulon 4
chr8_-_133772870 0.13 ENST00000522334.1
ENST00000519016.1
TMEM71
transmembrane protein 71
chr5_+_148206156 0.12 ENST00000305988.4
ADRB2
adrenoceptor beta 2, surface
chrX_+_115567767 0.12 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr2_-_180871780 0.12 ENST00000410053.3
ENST00000295749.6
ENST00000404136.2
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr4_+_86699834 0.12 ENST00000395183.2
ARHGAP24
Rho GTPase activating protein 24
chr10_+_81601114 0.12 ENST00000602967.1
ENST00000429984.3
NUTM2E
NUT family member 2E
chr2_-_145275828 0.12 ENST00000392861.2
ENST00000409211.1
ZEB2
zinc finger E-box binding homeobox 2
chr2_+_189157498 0.12 ENST00000359135.3
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr4_+_124320665 0.12 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_+_48823975 0.12 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr2_+_74229812 0.11 ENST00000305799.7
TET3
tet methylcytosine dioxygenase 3
chr8_+_91233750 0.11 ENST00000523406.1
LINC00534
long intergenic non-protein coding RNA 534
chr8_+_110552337 0.11 ENST00000337573.5
EBAG9
estrogen receptor binding site associated, antigen, 9
chr17_-_8059638 0.11 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr4_-_140477928 0.11 ENST00000274031.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_-_22222764 0.11 ENST00000439717.2
ENST00000412328.1
HSPG2
heparan sulfate proteoglycan 2
chr4_-_36246060 0.11 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_98262240 0.11 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr1_+_150898812 0.11 ENST00000271640.5
ENST00000448029.1
ENST00000368962.2
ENST00000534805.1
ENST00000368969.4
ENST00000368963.1
ENST00000498193.1
SETDB1
SET domain, bifurcated 1
chr9_+_131447342 0.11 ENST00000409104.3
SET
SET nuclear oncogene
chr19_+_50148087 0.11 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr3_+_152017181 0.10 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr3_-_57326704 0.10 ENST00000487349.1
ENST00000389601.3
ASB14
ankyrin repeat and SOCS box containing 14
chr17_+_48823896 0.10 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr11_-_26743546 0.10 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr8_+_76452097 0.10 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr12_-_8803128 0.10 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr10_+_81462983 0.10 ENST00000448135.1
ENST00000429828.1
ENST00000372321.1
NUTM2B
NUT family member 2B
chr6_-_27440460 0.10 ENST00000377419.1
ZNF184
zinc finger protein 184
chr12_-_10978957 0.10 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr3_+_75713481 0.10 ENST00000308062.3
ENST00000464571.1
FRG2C
FSHD region gene 2 family, member C
chr9_+_129097479 0.10 ENST00000402437.2
MVB12B
multivesicular body subunit 12B
chr12_+_69202795 0.10 ENST00000539479.1
ENST00000393415.3
ENST00000523991.1
ENST00000543323.1
ENST00000393416.2
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr10_-_14504093 0.09 ENST00000493380.1
ENST00000475141.2
FRMD4A
FERM domain containing 4A
chr5_-_43557791 0.09 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
PAIP1
poly(A) binding protein interacting protein 1
chr18_-_67615088 0.09 ENST00000582621.1
CD226
CD226 molecule
chr1_-_31538517 0.09 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr21_-_36421401 0.09 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr1_+_180601139 0.09 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr14_+_56584414 0.09 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr17_+_52978107 0.09 ENST00000445275.2
TOM1L1
target of myb1 (chicken)-like 1
chr7_-_944631 0.09 ENST00000453175.2
ADAP1
ArfGAP with dual PH domains 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 0.6 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.2 0.5 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.5 GO:0010966 regulation of phosphate transport(GO:0010966) regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369)
0.1 0.4 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.1 0.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:0001897 cytolysis by symbiont of host cells(GO:0001897)
0.1 0.3 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.3 GO:0021763 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 0.4 GO:0019075 virus maturation(GO:0019075)
0.1 0.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.9 GO:0030238 male sex determination(GO:0030238)
0.1 0.2 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.5 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.2 GO:0019249 lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0044727 chromatin reprogramming in the zygote(GO:0044725) DNA demethylation of male pronucleus(GO:0044727)
0.0 0.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.2 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.0 0.3 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0032848 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.4 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.1 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:2000323 circadian regulation of translation(GO:0097167) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.1 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.0 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.0 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0098844 postsynaptic endocytic zone(GO:0098843) postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 1.3 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 1.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.3 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.4 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.2 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.1 0.3 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.1 0.2 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.3 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.2 GO:0070404 NADH binding(GO:0070404)
0.0 0.4 GO:0050308 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.2 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.9 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0004583 alpha-1,3-mannosyltransferase activity(GO:0000033) dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0004936 adrenergic receptor activity(GO:0004935) alpha-adrenergic receptor activity(GO:0004936)
0.0 0.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.0 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network