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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NKX1-1
Z-value: 1.36
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Transcription factors associated with NKX1-1
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX1-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.0 | 3.0 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.0 | 2.4 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.1 | 2.0 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.6 | 1.8 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.2 | 1.7 | GO:0018211 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.3 | 1.6 | GO:0019249 | lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920) |
| 0.0 | 1.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.4 | 1.3 | GO:0060827 | regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829) |
| 0.0 | 0.8 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 2.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.2 | 2.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.2 | 1.8 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 1.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.5 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.3 | GO:0032133 | chromosome passenger complex(GO:0032133) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.0 | 1.6 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 1.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 1.3 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.7 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 0.6 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.5 | GO:0004452 | isopentenyl-diphosphate delta-isomerase activity(GO:0004452) |
| 0.0 | 0.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.7 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.6 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 0.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |