Project

A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for NKX1-1

Z-value: 1.36

Motif logo

logo of

Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_89442940 2.39 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr1_-_197115818 1.79 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr17_-_57232596 1.47 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr12_+_102513950 1.45 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr17_-_57232525 1.38 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr17_+_57233087 1.32 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr6_-_85473073 1.32 ENST00000606621.1
TBX18
T-box 18
chr12_+_16500037 1.26 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr4_+_66536248 1.17 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr17_+_57232690 1.08 ENST00000262293.4
PRR11
proline rich 11
chr12_+_16500599 1.05 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr3_+_158519654 0.88 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr19_+_32897009 0.88 ENST00000342179.5
ENST00000586427.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr2_-_239197238 0.82 ENST00000254657.3
PER2
period circadian clock 2
chr7_-_99716914 0.81 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr12_+_28410128 0.80 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr2_-_239197201 0.80 ENST00000254658.3
PER2
period circadian clock 2
chr19_+_32896697 0.79 ENST00000586987.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr12_+_16500571 0.79 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr10_+_99205959 0.77 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr10_+_120789223 0.73 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chrX_+_72783026 0.68 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr10_+_99205894 0.67 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr7_-_27239703 0.65 ENST00000222753.4
HOXA13
homeobox A13
chr1_-_108507631 0.62 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_174843548 0.59 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr1_-_159832438 0.59 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr1_-_221915418 0.58 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr17_-_27418537 0.57 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr19_+_39930212 0.57 ENST00000396843.1
AC011500.1
Interleukin-like; Uncharacterized protein
chr12_+_102514019 0.56 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr19_+_36249044 0.54 ENST00000444637.2
ENST00000396908.4
ENST00000544099.1
C19orf55
chromosome 19 open reading frame 55
chr11_-_105892937 0.53 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr7_+_26331541 0.53 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr3_-_52567792 0.52 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr18_-_33709268 0.51 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr17_-_45266542 0.50 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr14_-_88200641 0.49 ENST00000556168.1
RP11-1152H15.1
RP11-1152H15.1
chr11_-_4629388 0.46 ENST00000526337.1
ENST00000300747.5
TRIM68
tripartite motif containing 68
chr16_-_66864806 0.45 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr7_-_86849883 0.44 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr15_+_96904487 0.43 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr10_-_1094819 0.43 ENST00000429642.1
IDI1
isopentenyl-diphosphate delta isomerase 1
chr17_+_59489112 0.42 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr5_-_159546396 0.40 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr4_-_54232144 0.40 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr8_+_26371763 0.36 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr11_+_72983246 0.36 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr8_+_98656693 0.36 ENST00000519934.1
MTDH
metadherin
chr2_-_167232484 0.35 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr9_+_116225999 0.33 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr6_-_82957433 0.33 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chrX_-_47509994 0.31 ENST00000343894.4
ELK1
ELK1, member of ETS oncogene family
chr7_+_12727250 0.30 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr7_-_86849836 0.30 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr13_+_78315295 0.29 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr13_+_36050881 0.29 ENST00000537702.1
NBEA
neurobeachin
chr2_+_187371440 0.29 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr7_+_99717230 0.28 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr17_-_8113886 0.27 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
AURKB
aurora kinase B
chr3_+_57261743 0.27 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr3_-_105587879 0.26 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_+_119205222 0.26 ENST00000311413.4
RNF26
ring finger protein 26
chr7_-_73256838 0.22 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr1_-_51796987 0.20 ENST00000262676.5
TTC39A
tetratricopeptide repeat domain 39A
chr9_+_124329336 0.18 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr8_+_98656336 0.16 ENST00000336273.3
MTDH
metadherin
chr4_-_87515202 0.16 ENST00000502302.1
ENST00000513186.1
MAPK10
mitogen-activated protein kinase 10
chr1_+_161691353 0.15 ENST00000367948.2
FCRLB
Fc receptor-like B
chr17_-_44439084 0.15 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B
ADP-ribosylation factor-like 17B
chr14_-_24711764 0.14 ENST00000557921.1
ENST00000558476.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_71823715 0.13 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr6_-_80247105 0.13 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr1_-_151762900 0.13 ENST00000440583.2
TDRKH
tudor and KH domain containing
chr4_+_87515454 0.12 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr11_+_134201768 0.11 ENST00000535456.2
ENST00000339772.7
GLB1L2
galactosidase, beta 1-like 2
chr12_-_102513843 0.11 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr19_+_36249057 0.10 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55
chromosome 19 open reading frame 55
chr11_-_71823796 0.10 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr10_-_1095050 0.10 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr12_-_6961050 0.10 ENST00000538862.2
CDCA3
cell division cycle associated 3
chr17_-_40337470 0.09 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr17_-_44657017 0.09 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chr5_+_66300446 0.09 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr15_-_78526942 0.09 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr15_-_75199213 0.08 ENST00000562698.1
FAM219B
family with sequence similarity 219, member B
chr2_-_47142884 0.07 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr3_+_23851928 0.07 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr8_+_22132847 0.07 ENST00000521356.1
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr8_+_22132810 0.07 ENST00000356766.6
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr1_-_231004220 0.07 ENST00000366663.5
C1orf198
chromosome 1 open reading frame 198
chr8_+_94929077 0.06 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr15_-_78526855 0.05 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr15_-_64386120 0.05 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr8_+_94929168 0.04 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr4_+_128554081 0.04 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr5_+_66300464 0.04 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr7_+_26331678 0.02 ENST00000446848.2
SNX10
sorting nexin 10
chr11_-_4629367 0.02 ENST00000533021.1
TRIM68
tripartite motif containing 68
chr2_-_47143160 0.01 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr4_-_103682145 0.01 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr20_-_50722183 0.00 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.6 1.8 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.4 1.3 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.3 1.6 GO:0019249 lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.2 1.7 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.6 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 2.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.5 GO:0050993 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.0 0.8 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.3 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 2.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.5 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.7 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 3.0 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.4 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.0 0.2 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0072687 meiotic spindle(GO:0072687)
0.2 2.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 2.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.0 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 3.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.1 3.1 GO:0043295 glutathione binding(GO:0043295)
0.1 0.5 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.1 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 1.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.3 GO:0071553 uridine nucleotide receptor activity(GO:0015065) UDP-activated nucleotide receptor activity(GO:0045029) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 1.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 ST JNK MAPK PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 3.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors