ISMARA results: NFIX

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NFIX_NFIB

Z-value: 2.04

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Transcription factors associated with NFIX_NFIB

Gene Symbol	Gene ID	Gene Info
NFIX Ensembl NCBI GeneCards UniProt	ENSG00000008441.12	nuclear factor I X
NFIB Ensembl NCBI GeneCards UniProt	ENSG00000147862.10	nuclear factor I B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIX	hg19_v2_chr19_+_13106383_13106423	-0.93	6.7e-02	Click!
NFIB	hg19_v2_chr9_-_14322319_14322340	-0.43	5.7e-01	Click!

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_53207842 Show fit	1.58	ENST00000458244.2	KRT4 Ensembl NCBI GeneCards UniProt Show fit	keratin 4
chr10_-_101825151 Show fit	1.05	ENST00000441382.1	CPN1 Ensembl NCBI GeneCards UniProt Show fit	carboxypeptidase N, polypeptide 1
chr10_+_115312766 Show fit	0.90	ENST00000351270.3	HABP2 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan binding protein 2
chr18_+_29171689 Show fit	0.78	ENST00000237014.3	TTR Ensembl NCBI GeneCards UniProt Show fit	transthyretin
chrX_-_84363974 Show fit	0.74	ENST00000395409.3 ENST00000332921.5 ENST00000509231.1	SATL1 Ensembl NCBI GeneCards UniProt Show fit	spermidine/spermine N1-acetyl transferase-like 1
chr16_+_2198604 Show fit	0.66	ENST00000210187.6	RAB26 Ensembl NCBI GeneCards UniProt Show fit	RAB26, member RAS oncogene family
chr3_+_149192475 Show fit	0.64	ENST00000465758.1	TM4SF4 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 4 L six family member 4
chr22_-_36018569 Show fit	0.64	ENST00000419229.1 ENST00000406324.1	MB Ensembl NCBI GeneCards UniProt Show fit	myoglobin
chr6_-_34524049 Show fit	0.62	ENST00000374037.3	SPDEF Ensembl NCBI GeneCards UniProt Show fit	SAM pointed domain containing ETS transcription factor
chr1_+_207277590 Show fit	0.60	ENST00000367070.3	C4BPA Ensembl NCBI GeneCards UniProt Show fit	complement component 4 binding protein, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0043486	histone exchange(GO:0043486)
0.0	1.6	GO:0070268	cornification(GO:0070268)
0.2	1.5	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.4	1.3	GO:0030070	insulin processing(GO:0030070)
0.1	1.3	GO:1903027	regulation of opsonization(GO:1903027)
0.1	1.2	GO:0072592	oxygen metabolic process(GO:0072592)
0.1	1.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.1	1.1	GO:0030091	protein repair(GO:0030091)
0.1	1.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	1.0	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)

Showing 1 to 10 of 681 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0045095	keratin filament(GO:0045095)
0.1	1.3	GO:0000812	Swr1 complex(GO:0000812)
0.0	1.3	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	1.2	GO:0005876	spindle microtubule(GO:0005876)
0.0	1.1	GO:0000791	euchromatin(GO:0000791)
0.0	1.0	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	1.0	GO:0009925	basal plasma membrane(GO:0009925)
0.0	1.0	GO:0005801	cis-Golgi network(GO:0005801)
0.1	0.9	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.9	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)

Showing 1 to 10 of 198 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	1.2	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.2	1.1	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.3	0.8	GO:0004145	diamine N-acetyltransferase activity(GO:0004145)
0.1	0.8	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1	0.8	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.8	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	0.8	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.8	GO:0005212	structural constituent of eye lens(GO:0005212)
0.2	0.7	GO:0018685	alkane 1-monooxygenase activity(GO:0018685)

Showing 1 to 10 of 404 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.9	PID AURORA B PATHWAY	Aurora B signaling
1.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
1.7	PID PLK1 PATHWAY	PLK1 signaling events
1.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
1.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.8	PID FANCONI PATHWAY	Fanconi anemia pathway
0.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.7	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.6	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 10 of 28 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.8	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
1.8	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
1.7	REACTOME KINESINS	Genes involved in Kinesins
1.5	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
1.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.2	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
1.2	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 77 entries

Results for NFIX_NFIB

Z-value: 2.04

Motif logo

Transcription factors associated with NFIX_NFIB

Activity-expression correlation:

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: