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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for NFATC4
Z-value: 1.38
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Transcription factors associated with NFATC4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC4 | hg19_v2_chr14_+_24837226_24837547 | -0.76 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_89300158 Show fit | 1.06 |
ENST00000502870.1
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr6_-_26235206 Show fit | 0.93 |
ENST00000244534.5
|
histone cluster 1, H1d |
|
| chr12_-_89918982 Show fit | 0.84 |
ENST00000549504.1
|
POC1 centriolar protein B |
|
| chr14_+_74551650 Show fit | 0.80 |
ENST00000554938.1
|
lin-52 homolog (C. elegans) |
|
| chr16_+_53412368 Show fit | 0.79 |
ENST00000565189.1
|
RP11-44F14.2 |
|
| chr15_+_32933866 Show fit | 0.78 |
ENST00000300175.4
ENST00000413748.2 ENST00000494364.1 ENST00000497208.1 |
secretogranin V (7B2 protein) |
|
| chr14_+_32546274 Show fit | 0.77 |
ENST00000396582.2
|
Rho GTPase activating protein 5 |
|
| chr21_+_17791648 Show fit | 0.76 |
ENST00000602892.1
ENST00000418813.2 ENST00000435697.1 |
long intergenic non-protein coding RNA 478 |
|
| chr16_+_29690358 Show fit | 0.75 |
ENST00000395384.4
ENST00000562473.1 |
quinolinate phosphoribosyltransferase |
|
| chr17_-_1613663 Show fit | 0.73 |
ENST00000330676.6
|
TLC domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 1.3 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 1.1 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.0 | 1.1 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.0 | 1.0 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.3 | 0.9 | GO:0061433 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.0 | 0.8 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.1 | 0.7 | GO:0046874 | quinolinate metabolic process(GO:0046874) pyridine-containing compound catabolic process(GO:0072526) |
| 0.0 | 0.7 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 0.6 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 0.9 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.9 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.9 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 0.8 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.2 | 0.6 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 0.6 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.0 | 0.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.6 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.6 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.4 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 1.1 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.1 | 1.0 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.3 | 0.9 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.0 | 0.9 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.7 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.0 | 0.7 | GO:0016289 | CoA hydrolase activity(GO:0016289) |
| 0.0 | 0.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 0.6 | GO:0015616 | DNA translocase activity(GO:0015616) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.2 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.7 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.7 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.6 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.6 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |