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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for MXI1_MYC_MYCN
Z-value: 1.80
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Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MXI1 | hg19_v2_chr10_+_111967345_111967442 | -0.96 | 3.7e-02 | Click! |
| MYC | hg19_v2_chr8_+_128747757_128747800 | 0.50 | 5.0e-01 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | 0.08 | 9.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.3 | 2.6 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.0 | 2.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 2.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 2.1 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 0.1 | 1.9 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.1 | 1.7 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 1.4 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.0 | 1.4 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 1.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 3.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.9 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.4 | 2.6 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 2.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 2.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 1.6 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 1.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 1.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 2.1 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 2.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 1.8 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 1.7 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.4 | 1.5 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.2 | 1.4 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 1.4 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.3 | GO:0001618 | virus receptor activity(GO:0001618) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 3.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.9 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 2.1 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 2.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 1.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 1.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 1.4 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |