ISMARA results: MNT_HEY1

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for MNT_HEY1_HEY2

Z-value: 1.69

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Transcription factors associated with MNT_HEY1_HEY2

Gene Symbol	Gene ID	Gene Info
MNT Ensembl NCBI GeneCards UniProt	ENSG00000070444.10	MAX network transcriptional repressor
HEY1 Ensembl NCBI GeneCards UniProt	ENSG00000164683.12	hes related family bHLH transcription factor with YRPW motif 1
HEY2 Ensembl NCBI GeneCards UniProt	ENSG00000135547.4	hes related family bHLH transcription factor with YRPW motif 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MNT	hg19_v2_chr17_-_2304365_2304412	0.78	2.2e-01	Click!
HEY1	hg19_v2_chr8_-_80680078_80680101	-0.29	7.1e-01	Click!
HEY2	hg19_v2_chr6_+_126070726_126070768	0.05	9.5e-01	Click!

Activity profile of MNT_HEY1_HEY2 motif

Sorted Z-values of MNT_HEY1_HEY2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_58145889 Show fit	2.88	ENST00000547853.1	CDK4 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 4
chr1_+_150254936 Show fit	2.15	ENST00000447007.1 ENST00000369095.1 ENST00000369094.1	C1orf51 Ensembl NCBI GeneCards UniProt Show fit	chromosome 1 open reading frame 51
chr1_-_26233423 Show fit	1.89	ENST00000357865.2	STMN1 Ensembl NCBI GeneCards UniProt Show fit	stathmin 1
chr2_-_198364581 Show fit	1.46	ENST00000428204.1	HSPD1 Ensembl NCBI GeneCards UniProt Show fit	heat shock 60kDa protein 1 (chaperonin)
chr1_-_26232522 Show fit	1.32	ENST00000399728.1	STMN1 Ensembl NCBI GeneCards UniProt Show fit	stathmin 1
chr19_+_49458107 Show fit	1.26	ENST00000539787.1 ENST00000345358.7 ENST00000391871.3 ENST00000415969.2 ENST00000354470.3 ENST00000506183.1 ENST00000293288.8	BAX Ensembl NCBI GeneCards UniProt Show fit	BCL2-associated X protein
chr8_-_144679264 Show fit	1.21	ENST00000531953.1 ENST00000526133.1	EEF1D Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr9_+_96928516 Show fit	1.21	ENST00000602703.1	RP11-2B6.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-2B6.3
chr6_-_151773232 Show fit	1.18	ENST00000444024.1 ENST00000367303.4	RMND1 Ensembl NCBI GeneCards UniProt Show fit	required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr1_-_26232951 Show fit	1.13	ENST00000426559.2 ENST00000455785.2	STMN1 Ensembl NCBI GeneCards UniProt Show fit	stathmin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MNT_HEY1_HEY2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.9	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3	3.0	GO:1904636	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.2	2.5	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.4	2.2	GO:0015862	uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.7	2.0	GO:0034226	lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.6	1.9	GO:0002368	B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.0	1.8	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	1.8	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.2	1.6	GO:0072592	oxygen metabolic process(GO:0072592)
0.1	1.6	GO:0060155	platelet dense granule organization(GO:0060155)

Showing 1 to 10 of 347 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.0	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	2.1	GO:0031225	anchored component of membrane(GO:0031225)
0.2	1.9	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	1.9	GO:0031083	BLOC-1 complex(GO:0031083)
0.1	1.8	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1	1.5	GO:0000439	core TFIIH complex(GO:0000439)
0.1	1.3	GO:0042788	polysomal ribosome(GO:0042788)
0.0	1.3	GO:0032156	septin cytoskeleton(GO:0032156)
0.2	1.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.2	1.1	GO:0044326	dendritic spine neck(GO:0044326)

Showing 1 to 10 of 126 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.5	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.1	2.3	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.1	2.2	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4	2.0	GO:0005289	high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.1	2.0	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3	1.7	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.1	1.7	GO:0003746	translation elongation factor activity(GO:0003746)
0.2	1.6	GO:0004473	malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2	1.6	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	1.6	GO:0000217	DNA secondary structure binding(GO:0000217)

Showing 1 to 10 of 246 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	3.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.5	PID PLK1 PATHWAY	PLK1 signaling events
0.1	1.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	1.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	1.0	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	1.0	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.7	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	3.7	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	2.7	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	2.6	REACTOME TRANSLATION	Genes involved in Translation
0.0	2.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	2.0	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	1.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	1.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	1.5	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	1.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 73 entries

Results for MNT_HEY1_HEY2

Z-value: 1.69

Motif logo

Transcription factors associated with MNT_HEY1_HEY2

Activity-expression correlation:

Activity profile of MNT_HEY1_HEY2 motif

Sorted Z-values of MNT_HEY1_HEY2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MNT_HEY1_HEY2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: