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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for MLX_USF2_USF1_PAX2
Z-value: 1.91
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| USF2 | hg19_v2_chr19_+_35759968_35760042 | -0.79 | 2.1e-01 | Click! |
| PAX2 | hg19_v2_chr10_+_102505954_102505985 | 0.55 | 4.5e-01 | Click! |
| MLX | hg19_v2_chr17_+_40719073_40719092 | -0.31 | 6.9e-01 | Click! |
| USF1 | hg19_v2_chr1_-_161014731_161014788 | -0.29 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.6 | 3.9 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.1 | 3.8 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.5 | 3.6 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 3.2 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.3 | 3.0 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.3 | 2.7 | GO:0045629 | positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.1 | 2.1 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.2 | 2.0 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.1 | 2.0 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.2 | 4.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.6 | 3.8 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.3 | 2.9 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.4 | 2.4 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.5 | 2.0 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.2 | 1.9 | GO:0033503 | HULC complex(GO:0033503) |
| 0.2 | 1.8 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.3 | 1.6 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.1 | 1.6 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.4 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.3 | 3.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 3.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.6 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 2.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 2.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 2.1 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.6 | 1.8 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 0.6 | 1.8 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 4.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 2.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 1.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 1.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.0 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 3.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 2.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.1 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 1.9 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 1.8 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 1.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 1.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |