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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for MEIS2
Z-value: 1.46
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Transcription factors associated with MEIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS2 | hg19_v2_chr15_-_37393406_37393528 | 0.92 | 7.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_219283815 Show fit | 1.58 |
ENST00000248444.5
ENST00000454069.1 ENST00000392114.2 |
villin 1 |
|
| chr10_+_115312766 Show fit | 1.24 |
ENST00000351270.3
|
hyaluronan binding protein 2 |
|
| chr11_+_86502085 Show fit | 1.11 |
ENST00000527521.1
|
protease, serine, 23 |
|
| chr12_-_53207842 Show fit | 1.00 |
ENST00000458244.2
|
keratin 4 |
|
| chr10_-_90712520 Show fit | 0.91 |
ENST00000224784.6
|
actin, alpha 2, smooth muscle, aorta |
|
| chr22_-_20138302 Show fit | 0.90 |
ENST00000540078.1
ENST00000439765.2 |
uncharacterized protein LOC388849 |
|
| chr1_-_247171347 Show fit | 0.86 |
ENST00000339986.7
ENST00000487338.2 |
zinc finger protein 695 |
|
| chr5_+_139055055 Show fit | 0.83 |
ENST00000511457.1
|
CXXC finger protein 5 |
|
| chr3_+_38017264 Show fit | 0.82 |
ENST00000436654.1
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
|
| chr2_-_228244013 Show fit | 0.81 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.2 | 1.7 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.0 | 1.3 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
| 0.2 | 1.2 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
| 0.2 | 1.2 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.0 | 1.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 1.2 | GO:0034080 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 1.1 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 1.1 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 1.1 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.6 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 1.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 1.3 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 1.3 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 1.2 | GO:0012505 | endomembrane system(GO:0012505) |
| 0.0 | 1.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 1.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 1.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 1.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 1.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 1.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 1.3 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 1.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.3 | 1.0 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.1 | 0.9 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 1.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.9 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |