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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for MEF2B

Z-value: 0.69

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Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
ENSG00000213999.11 myocyte enhancer factor 2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg19_v2_chr19_-_19281054_19281098-0.287.2e-01Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_212782012 0.71 ENST00000341491.4
ENST00000366985.1
activating transcription factor 3
chr3_-_52486841 0.70 ENST00000496590.1
troponin C type 1 (slow)
chr1_+_156095951 0.59 ENST00000448611.2
ENST00000368297.1
lamin A/C
chr14_+_58797974 0.51 ENST00000417477.2
AT rich interactive domain 4A (RBP1-like)
chr6_-_33160231 0.50 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
collagen, type XI, alpha 2
chr12_-_49393092 0.45 ENST00000421952.2
dendrin
chr7_-_16872932 0.40 ENST00000419572.2
ENST00000412973.1
anterior gradient 2
chr2_-_86564776 0.40 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
receptor accessory protein 1
chr6_+_44194762 0.40 ENST00000371708.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr2_-_220117867 0.39 ENST00000456818.1
ENST00000447205.1
tubulin, alpha 4a
chr4_+_37892682 0.36 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr1_+_156096336 0.35 ENST00000504687.1
ENST00000473598.2
lamin A/C
chr3_+_186739636 0.34 ENST00000440338.1
ENST00000448044.1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr16_+_12059091 0.32 ENST00000562385.1
tumor necrosis factor receptor superfamily, member 17
chr3_-_176914238 0.31 ENST00000430069.1
ENST00000428970.1
transducin (beta)-like 1 X-linked receptor 1
chr2_-_157198860 0.30 ENST00000409572.1
nuclear receptor subfamily 4, group A, member 2
chr1_-_23751189 0.30 ENST00000374601.3
ENST00000450454.2
transcription elongation factor A (SII), 3
chr7_-_105332084 0.29 ENST00000472195.1
ataxin 7-like 1
chr3_-_176914191 0.29 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
transducin (beta)-like 1 X-linked receptor 1
chr7_+_133615169 0.29 ENST00000541309.1
exocyst complex component 4
chr11_-_18034701 0.27 ENST00000265965.5
secretion regulating guanine nucleotide exchange factor
chr1_-_19229014 0.26 ENST00000538839.1
ENST00000290597.5
aldehyde dehydrogenase 4 family, member A1
chr9_+_116327326 0.25 ENST00000342620.5
regulator of G-protein signaling 3
chr7_+_18535893 0.25 ENST00000432645.2
ENST00000441542.2
histone deacetylase 9
chr7_-_55583740 0.24 ENST00000453256.1
vesicular, overexpressed in cancer, prosurvival protein 1
chr12_+_52445191 0.24 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
nuclear receptor subfamily 4, group A, member 1
chr19_-_16008880 0.23 ENST00000011989.7
ENST00000221700.6
cytochrome P450, family 4, subfamily F, polypeptide 2
chr14_+_56046990 0.23 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
kinectin 1 (kinesin receptor)
chr17_-_42188598 0.23 ENST00000591714.1
histone deacetylase 5
chr6_+_42984723 0.23 ENST00000332245.8
kelch domain containing 3
chr4_-_25865159 0.22 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr17_-_42200996 0.21 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
histone deacetylase 5
chr1_+_145525015 0.21 ENST00000539363.1
ENST00000538811.1
integrin, alpha 10
chr22_+_32340447 0.21 ENST00000248975.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr1_-_204329013 0.21 ENST00000272203.3
ENST00000414478.1
pleckstrin homology domain containing, family A member 6
chr14_-_21493123 0.20 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG family member 2
chr11_-_47374246 0.20 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
myosin binding protein C, cardiac
chr22_+_32340481 0.20 ENST00000397492.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr14_+_76776957 0.20 ENST00000512784.1
estrogen-related receptor beta
chr14_+_56046914 0.19 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
kinectin 1 (kinesin receptor)
chr12_-_371994 0.18 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
solute carrier family 6 (neurotransmitter transporter), member 13
chr1_+_145524891 0.18 ENST00000369304.3
integrin, alpha 10
chr17_-_27467418 0.18 ENST00000528564.1
myosin XVIIIA
chr4_+_8321882 0.17 ENST00000509453.1
ENST00000503186.1
RP11-774O3.2
RP11-774O3.1
chr11_+_71934962 0.16 ENST00000543234.1
inositol polyphosphate phosphatase-like 1
chr5_-_42811986 0.16 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
selenoprotein P, plasma, 1
chr17_-_42200958 0.16 ENST00000336057.5
histone deacetylase 5
chr17_-_1389228 0.16 ENST00000438665.2
myosin IC
chr5_+_138609782 0.16 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
matrin 3
chr9_+_97766409 0.16 ENST00000425634.2
chromosome 9 open reading frame 3
chr3_+_8543561 0.16 ENST00000397386.3
LIM and cysteine-rich domains 1
chr14_-_21493884 0.15 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG family member 2
chr12_-_120189900 0.14 ENST00000546026.1
citron (rho-interacting, serine/threonine kinase 21)
chr7_-_37488834 0.14 ENST00000310758.4
engulfment and cell motility 1
chr1_-_204436344 0.14 ENST00000367184.2
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr17_-_1389419 0.14 ENST00000575158.1
myosin IC
chr9_+_97766469 0.13 ENST00000433691.2
chromosome 9 open reading frame 3
chr15_+_40226304 0.13 ENST00000559624.1
ENST00000382727.2
ENST00000263791.5
ENST00000560648.1
eukaryotic translation initiation factor 2 alpha kinase 4
chr20_+_44035847 0.13 ENST00000372712.2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_+_86781916 0.13 ENST00000579592.1
ENST00000434534.1
cyclin D binding myb-like transcription factor 1
chr4_+_44680429 0.13 ENST00000281543.5
GUF1 GTPase homolog (S. cerevisiae)
chr20_+_32581738 0.12 ENST00000333552.5
RALY heterogeneous nuclear ribonucleoprotein
chr17_-_48785216 0.12 ENST00000285243.6
ankyrin repeat domain 40
chr3_+_188664988 0.11 ENST00000433971.1
tumor protein p63 regulated 1
chr2_-_208030886 0.10 ENST00000426163.1
Kruppel-like factor 7 (ubiquitous)
chr14_-_21493649 0.10 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG family member 2
chr6_+_123038689 0.10 ENST00000354275.2
ENST00000368446.1
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr19_-_49926698 0.10 ENST00000270631.1
parathyroid hormone 2
chr20_+_11898507 0.09 ENST00000378226.2
BTB (POZ) domain containing 3
chr6_+_139094657 0.09 ENST00000332797.6
coiled-coil domain containing 28A
chr4_-_143767428 0.08 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr3_-_192445289 0.08 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
fibroblast growth factor 12
chr2_-_86564696 0.08 ENST00000437769.1
receptor accessory protein 1
chr4_-_185303418 0.08 ENST00000610223.1
ENST00000608785.1
RP11-290F5.1
chr6_-_123958051 0.08 ENST00000546248.1
triadin
chr16_-_67867749 0.08 ENST00000566758.1
ENST00000445712.2
ENST00000219172.3
ENST00000564817.1
centromere protein T
chr3_+_8543393 0.08 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LIM and cysteine-rich domains 1
chr15_-_52970820 0.08 ENST00000261844.7
ENST00000399202.4
ENST00000562135.1
family with sequence similarity 214, member A
chr2_-_190044480 0.08 ENST00000374866.3
collagen, type V, alpha 2
chrX_+_70521584 0.08 ENST00000373829.3
ENST00000538820.1
integrin beta 1 binding protein (melusin) 2
chr7_-_37488777 0.08 ENST00000445322.1
ENST00000448602.1
engulfment and cell motility 1
chr11_+_7597639 0.07 ENST00000533792.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_+_52430894 0.07 ENST00000546842.1
nuclear receptor subfamily 4, group A, member 1
chr3_+_49057876 0.07 ENST00000326912.4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr7_+_86781847 0.06 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
cyclin D binding myb-like transcription factor 1
chr14_+_101359265 0.06 ENST00000599197.1
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr22_+_19706958 0.06 ENST00000395109.2
septin 5
chr14_+_39735411 0.06 ENST00000603904.1
cTAGE family member 5 isoform 4
chr10_-_3827417 0.06 ENST00000497571.1
ENST00000542957.1
Kruppel-like factor 6
chr19_-_51220176 0.06 ENST00000359082.3
ENST00000293441.1
SH3 and multiple ankyrin repeat domains 1
chr1_-_201391149 0.06 ENST00000555948.1
ENST00000556362.1
troponin I type 1 (skeletal, slow)
chr5_-_150521192 0.06 ENST00000523714.1
ENST00000521749.1
annexin A6
chr17_+_7184986 0.05 ENST00000317370.8
ENST00000571308.1
solute carrier family 2 (facilitated glucose transporter), member 4
chr7_+_143013198 0.05 ENST00000343257.2
chloride channel, voltage-sensitive 1
chr17_-_39211463 0.05 ENST00000542910.1
ENST00000398477.1
keratin associated protein 2-2
chr3_-_11610255 0.05 ENST00000424529.2
vestigial like 4 (Drosophila)
chrX_-_11284095 0.05 ENST00000303025.6
ENST00000534860.1
Rho GTPase activating protein 6
chr3_+_46924829 0.05 ENST00000313049.5
parathyroid hormone 1 receptor
chr8_+_76452097 0.04 ENST00000396423.2
hepatocyte nuclear factor 4, gamma
chr1_+_22778337 0.04 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
zinc finger and BTB domain containing 40
chr8_+_1993173 0.04 ENST00000523438.1
myomesin 2
chr1_+_84630367 0.04 ENST00000370680.1
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_123957942 0.04 ENST00000398178.3
triadin
chr8_+_1993152 0.03 ENST00000262113.4
myomesin 2
chr10_-_3827371 0.03 ENST00000469435.1
Kruppel-like factor 6
chr20_+_44657845 0.03 ENST00000243964.3
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_+_8543533 0.03 ENST00000454244.1
LIM and cysteine-rich domains 1
chr11_-_47399942 0.03 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_-_16509101 0.03 ENST00000399793.2
family with sequence similarity 134, member B
chr7_-_37488547 0.03 ENST00000453399.1
engulfment and cell motility 1
chr19_+_16607122 0.02 ENST00000221671.3
ENST00000594035.1
ENST00000599550.1
ENST00000594813.1
chromosome 19 open reading frame 44
chr1_+_74701062 0.02 ENST00000326637.3
TNNI3 interacting kinase
chr4_-_143227088 0.02 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr3_+_138067314 0.02 ENST00000423968.2
muscle RAS oncogene homolog
chr12_+_54384370 0.02 ENST00000504315.1
homeobox C6
chr9_-_16728161 0.02 ENST00000603713.1
ENST00000603313.1
basonuclin 2
chr1_-_150693318 0.02 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMA domain containing 1
chr1_-_156460391 0.02 ENST00000360595.3
myocyte enhancer factor 2D
chr4_-_143226979 0.02 ENST00000514525.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr7_+_18126557 0.02 ENST00000417496.2
histone deacetylase 9
chr16_+_50313426 0.02 ENST00000569265.1
adenylate cyclase 7
chr10_-_31146615 0.02 ENST00000444692.2
zinc finger protein 438
chr17_+_20059302 0.02 ENST00000395530.2
sperm antigen with calponin homology and coiled-coil domains 1
chr11_-_7904464 0.02 ENST00000502624.2
ENST00000527565.1
RP11-35J10.5
chr9_-_74980113 0.01 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
zinc finger, AN1-type domain 5
chr2_-_208031542 0.01 ENST00000423015.1
Kruppel-like factor 7 (ubiquitous)
chr11_-_47400078 0.01 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr1_+_84630645 0.01 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr10_+_71561704 0.01 ENST00000520267.1
collagen, type XIII, alpha 1
chr9_-_102582155 0.00 ENST00000427039.1
RP11-554F20.1
chr3_+_127634069 0.00 ENST00000405109.1
kelch repeat and BTB (POZ) domain containing 12
chr11_+_47293795 0.00 ENST00000422579.1
MAP-kinase activating death domain
chr12_+_44229846 0.00 ENST00000551577.1
ENST00000266534.3
transmembrane protein 117

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 0.9 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.2 0.7 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.1 0.5 GO:0060023 soft palate development(GO:0060023)
0.1 0.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.4 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 0.2 GO:0003095 pressure natriuresis(GO:0003095)
0.1 0.2 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 0.4 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0060733 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.0 0.2 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.3 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.0 0.6 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.5 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.6 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 0.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.4 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.7 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.1 0.4 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.0 0.6 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0031013 troponin I binding(GO:0031013)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.3 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 0.2 GO:0018685 alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 0.6 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.1 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.0 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0032036 myosin heavy chain binding(GO:0032036)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)