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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for MECP2
Z-value: 2.55
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg19_v2_chrX_-_153363188_153363212 | -0.82 | 1.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 1.0 | 4.9 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 1.2 | 4.6 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
| 0.0 | 4.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.5 | 3.5 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 0.1 | 3.5 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.3 | 3.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 3.2 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.3 | 3.0 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.1 | 3.0 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | GO:0034705 | potassium channel complex(GO:0034705) |
| 0.0 | 5.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 4.7 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 4.0 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 3.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 3.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 3.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 3.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.2 | 3.1 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 3.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 5.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 1.2 | 4.6 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.0 | 4.5 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 3.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 3.4 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.0 | 3.3 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 3.1 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 3.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 5.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.9 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 4.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 4.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 2.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 7.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 6.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 5.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 5.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 5.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 4.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 3.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 3.9 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 3.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |