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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for MAF_NRL
Z-value: 1.05
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Transcription factors associated with MAF_NRL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRL | hg19_v2_chr14_-_24551137_24551178 | -0.93 | 7.0e-02 | Click! |
| MAF | hg19_v2_chr16_-_79634595_79634620 | 0.65 | 3.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_52076425 Show fit | 1.30 |
ENST00000436511.2
|
zinc finger protein 175 |
|
| chr2_-_191878162 Show fit | 0.98 |
ENST00000540176.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr19_+_39759154 Show fit | 0.84 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr1_-_1763721 Show fit | 0.63 |
ENST00000437146.1
|
guanine nucleotide binding protein (G protein), beta polypeptide 1 |
|
| chr11_-_615570 Show fit | 0.62 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
interferon regulatory factor 7 |
|
| chr17_-_54893250 Show fit | 0.62 |
ENST00000397862.2
|
chromosome 17 open reading frame 67 |
|
| chr2_-_191878681 Show fit | 0.61 |
ENST00000409465.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr11_+_118826999 Show fit | 0.52 |
ENST00000264031.2
|
uroplakin 2 |
|
| chr17_-_39769005 Show fit | 0.50 |
ENST00000301653.4
ENST00000593067.1 |
keratin 16 |
|
| chr8_-_145086922 Show fit | 0.47 |
ENST00000530478.1
|
poly (ADP-ribose) polymerase family, member 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAF_NRL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.9 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.1 | 0.7 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.0 | 0.7 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.0 | 0.7 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.2 | 0.6 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.0 | 0.6 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 0.6 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.0 | 0.6 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 0.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 0.5 | GO:0010966 | regulation of phosphate transport(GO:0010966) regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.5 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.1 | 0.5 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.1 | 0.4 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.1 | 0.4 | GO:0043260 | laminin-11 complex(GO:0043260) |
| 0.1 | 0.4 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.3 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.7 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 0.6 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.0 | 0.6 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.6 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.5 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.0 | 0.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 0.5 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.0 | 0.5 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.9 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.5 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.7 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.6 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.5 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.5 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |