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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for LHX8
Z-value: 1.61
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Transcription factors associated with LHX8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX8 | hg19_v2_chr1_+_75594119_75594119 | 0.92 | 8.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of LHX8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 2.8 | GO:2000257 | regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257) |
| 0.8 | 2.4 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641) |
| 0.8 | 2.3 | GO:0030070 | insulin processing(GO:0030070) |
| 0.2 | 2.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 1.9 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 1.8 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.5 | 1.6 | GO:0034226 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.0 | 1.6 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.3 | 0.9 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.4 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 2.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 2.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 1.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 0.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.1 | 0.8 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.0 | 0.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.7 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 0.6 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 0.6 | GO:0032010 | phagolysosome(GO:0032010) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.3 | 2.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 2.3 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 2.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 2.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.2 | 1.9 | GO:0071553 | uridine nucleotide receptor activity(GO:0015065) UDP-activated nucleotide receptor activity(GO:0045029) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553) |
| 0.3 | 1.6 | GO:0005287 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.1 | 0.9 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 0.8 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.7 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.6 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |