ISMARA results: LHX6

Project

A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for LHX6

Z-value: 1.01

Motif logo

Transcription factors associated with LHX6

Gene Symbol	Gene ID	Gene Info
LHX6 Ensembl NCBI GeneCards UniProt	ENSG00000106852.11	LIM homeobox 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LHX6	hg19_v2_chr9_-_124990680_124990719	-0.79	2.1e-01	Click!

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_5710919 Show fit	1.77	ENST00000379965.3 ENST00000425490.1	TRIM22 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 22
chr7_+_37723336 Show fit	1.75	ENST00000450180.1	GPR141 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 141
chr12_-_56753858 Show fit	1.68	ENST00000314128.4 ENST00000557235.1 ENST00000418572.2	STAT2 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 2, 113kDa
chr11_-_102668879 Show fit	1.05	ENST00000315274.6	MMP1 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_33913708 Show fit	0.97	ENST00000257818.2	LMO2 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 2 (rhombotin-like 1)
chr11_-_121986923 Show fit	0.83	ENST00000560104.1	BLID Ensembl NCBI GeneCards UniProt Show fit	BH3-like motif containing, cell death inducer
chr6_+_29691198 Show fit	0.77	ENST00000440587.2 ENST00000434407.2	HLA-F Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, F
chr6_+_29691056 Show fit	0.76	ENST00000414333.1 ENST00000334668.4 ENST00000259951.7	HLA-F Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, F
chr6_+_30457244 Show fit	0.76	ENST00000376630.4	HLA-E Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, E
chr19_-_54663473 Show fit	0.75	ENST00000222224.3	LENG1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte receptor cluster (LRC) member 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0090140	regulation of mitochondrial fission(GO:0090140)
0.0	1.8	GO:0010508	positive regulation of autophagy(GO:0010508)
0.2	1.5	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0	1.5	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	1.0	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	1.0	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.0	0.9	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.3	0.8	GO:2000564	antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) CD8-positive, alpha-beta T cell proliferation(GO:0035740) protection from natural killer cell mediated cytotoxicity(GO:0042270) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0	0.8	GO:1902475	L-alpha-amino acid transmembrane transport(GO:1902475)
0.0	0.7	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	1.9	GO:0015030	Cajal body(GO:0015030)
0.0	1.5	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	0.6	GO:0005600	collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1	0.6	GO:0043564	Ku70:Ku80 complex(GO:0043564)
0.0	0.5	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	0.3	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	0.3	GO:0097123	cyclin A1-CDK2 complex(GO:0097123)
0.0	0.3	GO:0071012	catalytic step 1 spliceosome(GO:0071012)
0.0	0.3	GO:0035976	AP1 complex(GO:0035976)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0003954	NADH dehydrogenase activity(GO:0003954)
0.0	1.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.2	1.5	GO:0046979	TAP2 binding(GO:0046979)
0.0	1.0	GO:0070888	E-box binding(GO:0070888)
0.1	0.8	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.8	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.1	0.6	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.6	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.6	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.5	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)

Showing 1 to 10 of 37 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	1.6	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.8	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.7	PID ATM PATHWAY	ATM pathway
0.0	0.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 7 of 7 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.2	1.5	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	1.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	0.9	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.7	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.6	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis

Showing 1 to 10 of 14 entries

Results for LHX6

Z-value: 1.01

Motif logo

Transcription factors associated with LHX6

Activity-expression correlation:

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: