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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for LEF1

Z-value: 0.72

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109089573_109089585-0.534.7e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_96869165 0.94 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr10_+_115312766 0.69 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr17_-_46035187 0.67 ENST00000300557.2
PRR15L
proline rich 15-like
chr10_+_54074033 0.62 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr6_+_64282447 0.55 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_-_76649546 0.54 ENST00000508510.1
ENST00000509561.1
ENST00000499709.2
ENST00000511868.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr13_-_67802549 0.54 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr10_-_33405600 0.49 ENST00000414308.1
RP11-342D11.3
RP11-342D11.3
chrX_+_80457442 0.48 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr16_+_53242350 0.45 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr4_+_95972822 0.43 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr17_+_4675175 0.42 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr2_+_181845763 0.41 ENST00000602499.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr10_+_115312825 0.41 ENST00000537906.1
ENST00000541666.1
HABP2
hyaluronan binding protein 2
chr21_+_17791648 0.38 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478
long intergenic non-protein coding RNA 478
chr4_+_90033968 0.34 ENST00000317005.2
TIGD2
tigger transposable element derived 2
chr15_-_37392086 0.34 ENST00000561208.1
MEIS2
Meis homeobox 2
chr3_+_107244229 0.33 ENST00000456419.1
ENST00000402163.2
BBX
bobby sox homolog (Drosophila)
chr5_-_34043310 0.33 ENST00000231338.7
C1QTNF3
C1q and tumor necrosis factor related protein 3
chr5_+_138210919 0.33 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr3_-_112360116 0.33 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80
chrX_-_135962876 0.32 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr9_-_97356075 0.31 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chrX_-_45629661 0.31 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
RP6-99M1.2
chr8_-_95220775 0.31 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr5_+_31193847 0.31 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_-_65533390 0.30 ENST00000448344.1
RP4-535B20.1
RP4-535B20.1
chr14_+_58797974 0.30 ENST00000417477.2
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr1_+_27668505 0.29 ENST00000318074.5
SYTL1
synaptotagmin-like 1
chr12_+_94071129 0.29 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr5_+_137514834 0.28 ENST00000508792.1
ENST00000504621.1
KIF20A
kinesin family member 20A
chr20_+_36531499 0.28 ENST00000373458.3
ENST00000373461.4
ENST00000373459.4
VSTM2L
V-set and transmembrane domain containing 2 like
chr14_+_38065052 0.28 ENST00000556845.1
TTC6
tetratricopeptide repeat domain 6
chr6_+_43968306 0.27 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr5_+_137514687 0.27 ENST00000394894.3
KIF20A
kinesin family member 20A
chr6_-_29527702 0.27 ENST00000377050.4
UBD
ubiquitin D
chr14_-_67981916 0.27 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr1_-_93645818 0.27 ENST00000370280.1
ENST00000479918.1
TMED5
transmembrane emp24 protein transport domain containing 5
chr1_+_6845578 0.26 ENST00000467404.2
ENST00000439411.2
CAMTA1
calmodulin binding transcription activator 1
chr11_-_111794446 0.26 ENST00000527950.1
CRYAB
crystallin, alpha B
chr4_+_57774042 0.26 ENST00000309042.7
REST
RE1-silencing transcription factor
chr2_+_70056762 0.26 ENST00000282570.3
GMCL1
germ cell-less, spermatogenesis associated 1
chr1_-_156542328 0.26 ENST00000361170.2
IQGAP3
IQ motif containing GTPase activating protein 3
chr4_-_140477928 0.26 ENST00000274031.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr14_-_65409502 0.25 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr15_-_37393406 0.25 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr7_+_16793160 0.25 ENST00000262067.4
TSPAN13
tetraspanin 13
chr3_-_167813672 0.25 ENST00000470487.1
GOLIM4
golgi integral membrane protein 4
chr1_+_47799542 0.24 ENST00000471289.2
ENST00000450808.2
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr1_-_219615984 0.24 ENST00000420762.1
RP11-95P13.1
RP11-95P13.1
chr1_+_9242221 0.24 ENST00000412639.2
RP3-510D11.2
RP3-510D11.2
chr4_-_139163491 0.23 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr7_+_30185406 0.23 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr5_+_137673200 0.23 ENST00000434981.2
FAM53C
family with sequence similarity 53, member C
chr18_-_25616519 0.23 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr11_-_75921780 0.23 ENST00000529461.1
WNT11
wingless-type MMTV integration site family, member 11
chr3_+_186648307 0.23 ENST00000457772.2
ENST00000455441.1
ENST00000427315.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr11_-_76155618 0.23 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr14_+_75746664 0.22 ENST00000557139.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr20_+_57875457 0.22 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr17_-_27503770 0.22 ENST00000533112.1
MYO18A
myosin XVIIIA
chr15_+_52311398 0.22 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr2_+_181845843 0.22 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chrX_-_135962923 0.22 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr2_-_107503558 0.22 ENST00000361686.4
ENST00000409087.3
ST6GAL2
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
chr12_+_94071341 0.22 ENST00000542893.2
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr20_+_36531544 0.22 ENST00000448944.1
VSTM2L
V-set and transmembrane domain containing 2 like
chr1_+_53793885 0.22 ENST00000445039.2
RP4-784A16.5
RP4-784A16.5
chr1_-_108231101 0.22 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr15_-_37391614 0.21 ENST00000219869.9
MEIS2
Meis homeobox 2
chr16_-_15736881 0.21 ENST00000540441.2
KIAA0430
KIAA0430
chr1_-_54304212 0.21 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr20_+_37554955 0.21 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr6_+_64281906 0.21 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_-_52944231 0.21 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr18_+_9136758 0.21 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr14_-_38064198 0.21 ENST00000250448.2
FOXA1
forkhead box A1
chr16_-_70719925 0.21 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr5_+_172068232 0.21 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B
neuralized E3 ubiquitin protein ligase 1B
chrX_-_39956656 0.21 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr17_-_46623441 0.20 ENST00000330070.4
HOXB2
homeobox B2
chr14_+_75746781 0.20 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_+_104359614 0.20 ENST00000266775.9
ENST00000544861.1
TDG
thymine-DNA glycosylase
chr3_+_186648274 0.20 ENST00000169298.3
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr4_+_95128748 0.20 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr15_+_96873921 0.20 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr21_+_35552978 0.20 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr5_+_137514403 0.20 ENST00000513276.1
KIF20A
kinesin family member 20A
chrX_-_77041685 0.20 ENST00000373344.5
ENST00000395603.3
ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr5_+_145317356 0.20 ENST00000511217.1
SH3RF2
SH3 domain containing ring finger 2
chr4_-_23891693 0.20 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr13_+_37581115 0.19 ENST00000481013.1
EXOSC8
exosome component 8
chr3_-_167813132 0.19 ENST00000309027.4
GOLIM4
golgi integral membrane protein 4
chr1_+_196621002 0.19 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr22_+_37959647 0.19 ENST00000415670.1
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr11_-_75017734 0.19 ENST00000532525.1
ARRB1
arrestin, beta 1
chr16_+_67063142 0.19 ENST00000412916.2
CBFB
core-binding factor, beta subunit
chr1_+_82266053 0.19 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr1_-_235491462 0.19 ENST00000418304.1
ENST00000264183.3
ENST00000349213.3
ARID4B
AT rich interactive domain 4B (RBP1-like)
chr1_-_226496772 0.18 ENST00000359525.2
ENST00000460719.1
LIN9
lin-9 homolog (C. elegans)
chr7_-_84121858 0.18 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_-_141747459 0.18 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_62432777 0.18 ENST00000532971.1
METTL12
methyltransferase like 12
chr18_+_72922710 0.18 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr6_-_153304148 0.18 ENST00000229758.3
FBXO5
F-box protein 5
chrX_+_56590002 0.18 ENST00000338222.5
UBQLN2
ubiquilin 2
chr21_+_35553045 0.18 ENST00000416145.1
ENST00000430922.1
ENST00000419881.2
LINC00310
long intergenic non-protein coding RNA 310
chr3_-_125655882 0.18 ENST00000340333.3
ALG1L
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like
chr12_-_53994805 0.18 ENST00000328463.7
ATF7
activating transcription factor 7
chr17_-_39165366 0.18 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr8_-_21988558 0.17 ENST00000312841.8
HR
hair growth associated
chrX_+_38420783 0.17 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr14_-_67981870 0.17 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr20_+_11898507 0.17 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr15_+_36887069 0.17 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
C15orf41
chromosome 15 open reading frame 41
chr3_+_189349162 0.17 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63
tumor protein p63
chr1_+_93913713 0.17 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr2_-_211341411 0.17 ENST00000233714.4
ENST00000443314.1
ENST00000441020.3
ENST00000450366.2
ENST00000431941.2
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)
chr15_+_57511609 0.17 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr16_-_30798492 0.17 ENST00000262525.4
ZNF629
zinc finger protein 629
chr6_-_153304697 0.17 ENST00000367241.3
FBXO5
F-box protein 5
chr2_-_170681324 0.17 ENST00000409340.1
METTL5
methyltransferase like 5
chr9_+_124088860 0.16 ENST00000373806.1
GSN
gelsolin
chr4_+_76649753 0.16 ENST00000603759.1
USO1
USO1 vesicle transport factor
chr14_-_31676674 0.16 ENST00000399332.1
ENST00000556224.1
HECTD1
HECT domain containing E3 ubiquitin protein ligase 1
chr16_-_4987065 0.16 ENST00000590782.2
ENST00000345988.2
PPL
periplakin
chr17_+_57297807 0.16 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr17_-_70053866 0.16 ENST00000540802.1
RP11-84E24.2
RP11-84E24.2
chr8_-_17579726 0.16 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr17_+_29815013 0.16 ENST00000394744.2
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr11_-_102323489 0.16 ENST00000361236.3
TMEM123
transmembrane protein 123
chr1_+_196621156 0.16 ENST00000359637.2
CFH
complement factor H
chr5_+_162930114 0.16 ENST00000280969.5
MAT2B
methionine adenosyltransferase II, beta
chr5_+_92919043 0.16 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr22_+_27053422 0.16 ENST00000413665.1
ENST00000421151.1
ENST00000456129.1
ENST00000430080.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chr17_-_46682321 0.16 ENST00000225648.3
ENST00000484302.2
HOXB6
homeobox B6
chr14_-_23451467 0.16 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr14_+_54976546 0.15 ENST00000216420.7
CGRRF1
cell growth regulator with ring finger domain 1
chr2_+_18059906 0.15 ENST00000304101.4
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr4_+_76649797 0.15 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr2_-_157189180 0.15 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_100435315 0.15 ENST00000370155.3
ENST00000465289.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr3_+_149535022 0.15 ENST00000466795.1
RNF13
ring finger protein 13
chr2_-_48132814 0.15 ENST00000316377.4
ENST00000378314.3
FBXO11
F-box protein 11
chr10_+_123970670 0.15 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr4_+_95128996 0.15 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr18_+_19668021 0.15 ENST00000579830.1
RP11-595B24.2
Uncharacterized protein
chr9_+_116638562 0.15 ENST00000374126.5
ENST00000288466.7
ZNF618
zinc finger protein 618
chr6_+_83777374 0.15 ENST00000349129.2
ENST00000237163.5
ENST00000536812.1
DOPEY1
dopey family member 1
chr8_+_22019168 0.15 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC
surfactant protein C
chr5_+_65018017 0.15 ENST00000380985.5
ENST00000502464.1
NLN
neurolysin (metallopeptidase M3 family)
chr18_-_53089723 0.15 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr10_-_32345305 0.15 ENST00000302418.4
KIF5B
kinesin family member 5B
chr5_-_135701164 0.15 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr8_+_42873548 0.14 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr11_-_102323740 0.14 ENST00000398136.2
TMEM123
transmembrane protein 123
chr12_+_104359576 0.14 ENST00000392872.3
ENST00000436021.2
TDG
thymine-DNA glycosylase
chr1_+_32479430 0.14 ENST00000327300.7
ENST00000492989.1
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr1_+_93645314 0.14 ENST00000343253.7
CCDC18
coiled-coil domain containing 18
chr3_+_152017924 0.14 ENST00000465907.2
ENST00000492948.1
ENST00000485509.1
ENST00000464596.1
MBNL1
muscleblind-like splicing regulator 1
chr12_-_112443830 0.14 ENST00000550037.1
ENST00000549425.1
TMEM116
transmembrane protein 116
chr21_+_17791838 0.14 ENST00000453910.1
LINC00478
long intergenic non-protein coding RNA 478
chr17_-_63556414 0.14 ENST00000585045.1
AXIN2
axin 2
chr19_+_1249869 0.14 ENST00000591446.2
MIDN
midnolin
chr5_+_95066823 0.14 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr2_-_86564776 0.14 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr6_+_27925019 0.14 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr15_+_93443419 0.14 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr21_-_34144157 0.14 ENST00000331923.4
PAXBP1
PAX3 and PAX7 binding protein 1
chr2_-_26569611 0.14 ENST00000541401.1
ENST00000433584.1
ENST00000333478.6
GPR113
G protein-coupled receptor 113
chr14_+_64971292 0.14 ENST00000358738.3
ENST00000394712.2
ZBTB1
zinc finger and BTB domain containing 1
chr18_-_45456693 0.13 ENST00000587421.1
SMAD2
SMAD family member 2
chr4_-_157892055 0.13 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr2_-_170681375 0.13 ENST00000410097.1
ENST00000308099.3
ENST00000409837.1
ENST00000538491.1
ENST00000260953.5
ENST00000409965.1
ENST00000392640.2
METTL5
methyltransferase like 5
chr3_-_148804275 0.13 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr3_-_47823298 0.13 ENST00000254480.5
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr20_+_57875758 0.13 ENST00000395654.3
EDN3
endothelin 3
chr15_+_78730531 0.13 ENST00000258886.8
IREB2
iron-responsive element binding protein 2
chr14_+_56078695 0.13 ENST00000416613.1
KTN1
kinectin 1 (kinesin receptor)
chr11_-_117747434 0.13 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr16_+_67063036 0.13 ENST00000290858.6
ENST00000564034.1
CBFB
core-binding factor, beta subunit
chr18_-_24237339 0.13 ENST00000580191.1
KCTD1
potassium channel tetramerization domain containing 1
chr14_-_23451845 0.13 ENST00000262713.2
AJUBA
ajuba LIM protein
chr1_+_100435535 0.13 ENST00000427993.2
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr3_-_56809685 0.13 ENST00000413728.2
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr1_+_166808667 0.13 ENST00000537173.1
ENST00000536514.1
ENST00000449930.1
POGK
pogo transposable element with KRAB domain
chr4_+_95129061 0.13 ENST00000354268.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_+_78078304 0.13 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chr2_-_47572105 0.13 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr1_+_84630053 0.13 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_141106643 0.12 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr13_+_39612442 0.12 ENST00000470258.1
ENST00000379600.3
NHLRC3
NHL repeat containing 3
chr2_+_145425573 0.12 ENST00000600064.1
ENST00000597670.1
ENST00000414256.1
ENST00000599187.1
ENST00000451774.1
ENST00000599072.1
ENST00000596589.1
ENST00000597893.1
TEX41
testis expressed 41 (non-protein coding)
chr11_+_93861993 0.12 ENST00000227638.3
ENST00000436171.2
PANX1
pannexin 1
chr5_+_175288631 0.12 ENST00000509837.1
CPLX2
complexin 2
chr22_-_23484246 0.12 ENST00000216036.4
RTDR1
rhabdoid tumor deletion region gene 1
chr5_+_65222438 0.12 ENST00000380938.2
ERBB2IP
erbb2 interacting protein
chrX_-_63425561 0.12 ENST00000374869.3
ENST00000330258.3
AMER1
APC membrane recruitment protein 1
chr20_-_656437 0.12 ENST00000488788.2
RP5-850E9.3
Uncharacterized protein
chr7_-_102985035 0.12 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0009956 radial pattern formation(GO:0009956)
0.2 0.6 GO:0100012 negative regulation of mesodermal cell fate specification(GO:0042662) motor learning(GO:0061743) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.1 0.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.3 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.1 0.4 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.1 0.3 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.3 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.4 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 0.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.2 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.1 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.1 0.2 GO:0015709 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.1 0.2 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 0.2 GO:1903450 regulation of G1 to G0 transition(GO:1903450) positive regulation of G1 to G0 transition(GO:1903452)
0.1 0.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.2 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:1903217 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.2 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:1904640 positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.0 0.3 GO:0071638 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.2 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.0 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.2 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.1 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.2 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0 0.3 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.2 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.0 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.1 GO:0003163 sinoatrial node development(GO:0003163) sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0 0.5 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0048880 sensory system development(GO:0048880)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.0 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.0 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.0 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.0 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.4 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0075341 host cell PML body(GO:0075341)
0.0 0.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.4 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.3 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.0 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.0 GO:0031905 early endosome lumen(GO:0031905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.3 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.3 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.1 0.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.3 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.7 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.0 0.1 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 1.1 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.0 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.0 GO:0030350 iron-responsive element binding(GO:0030350)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.0 GO:1990175 EH domain binding(GO:1990175)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0043295 glutathione binding(GO:0043295)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.0 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription