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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for KLF3
Z-value: 2.18
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Transcription factors associated with KLF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg19_v2_chr4_+_38665810_38665827 | -0.68 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.7 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.1 | 3.0 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.3 | 2.8 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.0 | 2.5 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.5 | 2.4 | GO:0010847 | regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213) |
| 0.3 | 2.1 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.0 | 2.0 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.3 | 1.9 | GO:0019556 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.1 | 1.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 1.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 2.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 2.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 2.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 1.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 1.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 1.2 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 1.1 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 3.0 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 2.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 2.5 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.3 | 2.1 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.1 | 2.0 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.6 | 1.9 | GO:0004397 | histidine ammonia-lyase activity(GO:0004397) |
| 0.0 | 1.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.5 | 1.8 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.1 | 1.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 1.8 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.3 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 1.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 2.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.9 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 1.8 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 1.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.5 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.4 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 1.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |