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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for KLF12
Z-value: 1.35
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Transcription factors associated with KLF12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF12 | hg19_v2_chr13_-_74708372_74708409 | 0.86 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_153750622 Show fit | 1.00 |
ENST00000532853.1
|
solute carrier family 27 (fatty acid transporter), member 3 |
|
| chr12_-_56120838 Show fit | 0.66 |
ENST00000548160.1
|
CD63 molecule |
|
| chr22_-_39268308 Show fit | 0.58 |
ENST00000407418.3
|
chromobox homolog 6 |
|
| chr4_-_5710257 Show fit | 0.57 |
ENST00000344938.1
ENST00000344408.5 |
Ellis van Creveld syndrome 2 |
|
| chr17_+_27071002 Show fit | 0.51 |
ENST00000262395.5
ENST00000422344.1 ENST00000444415.3 ENST00000262396.6 |
TNF receptor-associated factor 4 |
|
| chr12_-_56120865 Show fit | 0.50 |
ENST00000548898.1
ENST00000552067.1 |
CD63 molecule |
|
| chr6_-_107436473 Show fit | 0.48 |
ENST00000369042.1
|
BEN domain containing 3 |
|
| chr17_+_1665253 Show fit | 0.46 |
ENST00000254722.4
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
|
| chr5_-_139930713 Show fit | 0.44 |
ENST00000602657.1
|
steroid receptor RNA activator 1 |
|
| chr4_+_3443614 Show fit | 0.42 |
ENST00000382774.3
ENST00000511533.1 |
HGF activator |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 0.7 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 0.7 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.0 | 0.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.5 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.1 | 0.5 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 0.5 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 0.5 | GO:0006882 | cellular zinc ion homeostasis(GO:0006882) |
| 0.1 | 0.4 | GO:0035623 | renal glucose absorption(GO:0035623) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 0.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.8 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.1 | 0.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.7 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 0.5 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.4 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.1 | 0.3 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.0 | 0.3 | GO:0097361 | CIA complex(GO:0097361) |
| 0.0 | 0.3 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.6 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.6 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.4 | GO:0031859 | platelet activating factor receptor binding(GO:0031859) |
| 0.1 | 0.4 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
| 0.1 | 0.4 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.7 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.6 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.7 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.3 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.3 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |