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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for JUN
Z-value: 2.64
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Transcription factors associated with JUN
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JUN | hg19_v2_chr1_-_59249732_59249785 | 0.18 | 8.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of JUN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.7 | 4.9 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.1 | 4.2 | GO:0045907 | positive regulation of vasoconstriction(GO:0045907) |
| 0.1 | 3.9 | GO:0007567 | parturition(GO:0007567) |
| 0.3 | 3.0 | GO:0010040 | response to iron(II) ion(GO:0010040) |
| 0.2 | 2.9 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.2 | 2.7 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 2.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.2 | 2.6 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.3 | 2.5 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 4.2 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 3.1 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 3.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 3.0 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 2.8 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.3 | 2.6 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 2.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.9 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 5.1 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 1.0 | 4.9 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 3.5 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 3.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 3.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 2.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 2.7 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 2.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 2.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 3.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.1 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 2.6 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.1 | 1.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.4 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 1.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |