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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ISX
Z-value: 1.23
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Transcription factors associated with ISX
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_94789663 Show fit | 1.77 |
ENST00000557225.1
ENST00000341584.3 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 |
|
| chr16_+_12059091 Show fit | 1.50 |
ENST00000562385.1
|
tumor necrosis factor receptor superfamily, member 17 |
|
| chr4_-_89442940 Show fit | 1.39 |
ENST00000527353.1
|
phosphatidylinositol glycan anchor biosynthesis, class Y |
|
| chr2_-_228244013 Show fit | 1.16 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
|
| chr10_+_91461337 Show fit | 1.03 |
ENST00000260753.4
ENST00000416354.1 ENST00000394289.2 ENST00000371728.3 |
kinesin family member 20B |
|
| chr1_+_28261492 Show fit | 1.03 |
ENST00000373894.3
|
sphingomyelin phosphodiesterase, acid-like 3B |
|
| chr1_-_197115818 Show fit | 0.92 |
ENST00000367409.4
ENST00000294732.7 |
asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
|
| chr17_-_18266818 Show fit | 0.89 |
ENST00000583780.1
|
serine hydroxymethyltransferase 1 (soluble) |
|
| chr4_+_66536248 Show fit | 0.87 |
ENST00000514260.1
ENST00000507117.1 |
RP11-807H7.1 |
|
| chr17_-_57229155 Show fit | 0.80 |
ENST00000584089.1
|
spindle and kinetochore associated complex subunit 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ISX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.5 | 1.5 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.4 | 1.5 | GO:1904481 | response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482) |
| 0.0 | 1.5 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.0 | 1.4 | GO:0006505 | GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 1.2 | GO:0008211 | glucocorticoid metabolic process(GO:0008211) |
| 0.2 | 1.1 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.0 | 1.1 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.1 | 1.0 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.3 | 0.9 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 1.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 1.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 1.1 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 0.9 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.6 | GO:0097362 | MCM8-MCM9 complex(GO:0097362) |
| 0.0 | 0.5 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.4 | GO:0019031 | viral envelope(GO:0019031) viral membrane(GO:0036338) |
| 0.0 | 0.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 1.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 1.5 | GO:0070905 | serine binding(GO:0070905) |
| 0.1 | 1.5 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.0 | 1.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.9 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.8 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.1 | 0.7 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.3 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 0.7 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.6 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.6 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |