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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ISX

Z-value: 1.23

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Transcription factors associated with ISX

Gene Symbol Gene ID Gene Info
ISX
ENSG00000175329.8 intestine specific homeobox

Activity profile of ISX motif

Sorted Z-values of ISX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_94789663 1.77 ENST00000557225.1
ENST00000341584.3
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr16_+_12059091 1.50 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr4_-_89442940 1.39 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr2_-_228244013 1.16 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr10_+_91461337 1.03 ENST00000260753.4
ENST00000416354.1
ENST00000394289.2
ENST00000371728.3
KIF20B
kinesin family member 20B
chr1_+_28261492 1.03 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr1_-_197115818 0.92 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr17_-_18266818 0.89 ENST00000583780.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr4_+_66536248 0.87 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr17_-_57229155 0.80 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr19_-_4717835 0.77 ENST00000599248.1
DPP9
dipeptidyl-peptidase 9
chr1_-_143913143 0.74 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr1_-_112281875 0.72 ENST00000527621.1
ENST00000534365.1
ENST00000357260.5
FAM212B
family with sequence similarity 212, member B
chr1_+_28261621 0.71 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr11_+_95523621 0.68 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr12_+_69201923 0.64 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr6_+_31126291 0.60 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr11_-_62414070 0.60 ENST00000540933.1
ENST00000346178.4
ENST00000356638.3
ENST00000534779.1
ENST00000525994.1
GANAB
glucosidase, alpha; neutral AB
chr5_-_159846066 0.60 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr12_+_16500037 0.59 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr2_-_3521518 0.58 ENST00000382093.5
ADI1
acireductone dioxygenase 1
chr6_-_85474219 0.58 ENST00000369663.5
TBX18
T-box 18
chr19_-_52307357 0.58 ENST00000594900.1
FPR1
formyl peptide receptor 1
chr11_-_95522639 0.56 ENST00000536839.1
FAM76B
family with sequence similarity 76, member B
chr1_+_28261533 0.55 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr6_-_111927062 0.54 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr14_-_88200641 0.53 ENST00000556168.1
RP11-1152H15.1
RP11-1152H15.1
chr4_-_174255536 0.53 ENST00000446922.2
HMGB2
high mobility group box 2
chr3_-_149095652 0.52 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr6_-_111927449 0.52 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr10_+_99205959 0.52 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr12_+_16500599 0.52 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr17_+_59489112 0.51 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chrX_+_43515467 0.51 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr8_+_38831683 0.48 ENST00000302495.4
HTRA4
HtrA serine peptidase 4
chrX_+_77166172 0.47 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chrY_+_14813160 0.47 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr20_+_44441271 0.45 ENST00000335046.3
ENST00000243893.6
UBE2C
ubiquitin-conjugating enzyme E2C
chr6_-_119256279 0.45 ENST00000316068.3
MCM9
minichromosome maintenance complex component 9
chr9_+_99212403 0.44 ENST00000375251.3
ENST00000375249.4
HABP4
hyaluronan binding protein 4
chr13_+_40229764 0.43 ENST00000416691.1
ENST00000422759.2
ENST00000455146.3
COG6
component of oligomeric golgi complex 6
chr3_+_28390637 0.43 ENST00000420223.1
ENST00000383768.2
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr9_+_104296163 0.42 ENST00000374819.2
ENST00000479306.1
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr12_+_16500571 0.41 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr7_-_86849836 0.40 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr8_+_110552046 0.40 ENST00000529931.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr1_+_206138457 0.39 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr15_-_55700457 0.39 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr1_-_159832438 0.38 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr20_+_44441215 0.38 ENST00000356455.4
ENST00000405520.1
UBE2C
ubiquitin-conjugating enzyme E2C
chr10_+_99205894 0.38 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_-_141348789 0.37 ENST00000414773.1
CLGN
calmegin
chr7_-_64467031 0.37 ENST00000394323.2
ERV3-1
endogenous retrovirus group 3, member 1
chr11_+_77532233 0.37 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr3_-_15563229 0.36 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr14_+_52313833 0.36 ENST00000553560.1
GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr10_-_105110831 0.36 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr19_-_47137942 0.36 ENST00000300873.4
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr5_+_159848807 0.36 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr4_-_87515202 0.35 ENST00000502302.1
ENST00000513186.1
MAPK10
mitogen-activated protein kinase 10
chr21_+_35014783 0.35 ENST00000381291.4
ENST00000381285.4
ENST00000399367.3
ENST00000399352.1
ENST00000399355.2
ENST00000399349.1
ITSN1
intersectin 1 (SH3 domain protein)
chr15_+_48413169 0.34 ENST00000341459.3
ENST00000482911.2
SLC24A5
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
chr19_-_51071302 0.34 ENST00000389201.3
ENST00000600381.1
LRRC4B
leucine rich repeat containing 4B
chrX_+_108779004 0.34 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr17_-_40828969 0.33 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr14_+_104182105 0.32 ENST00000311141.2
ZFYVE21
zinc finger, FYVE domain containing 21
chr5_-_95297678 0.32 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr10_-_1094819 0.32 ENST00000429642.1
IDI1
isopentenyl-diphosphate delta isomerase 1
chr14_-_53258314 0.32 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr17_-_27418537 0.31 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr17_-_40829026 0.30 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr6_+_130339710 0.30 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr1_+_120839005 0.30 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chrX_+_37639302 0.30 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr7_+_115862858 0.29 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr20_+_24449821 0.29 ENST00000376862.3
SYNDIG1
synapse differentiation inducing 1
chr3_-_129147432 0.29 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EFCAB12
EF-hand calcium binding domain 12
chr11_+_100862811 0.29 ENST00000303130.2
TMEM133
transmembrane protein 133
chr4_-_141348763 0.27 ENST00000509477.1
CLGN
calmegin
chr9_+_131452239 0.27 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr5_-_95297534 0.26 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chrX_+_77154935 0.26 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr12_-_10978957 0.25 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr4_-_141348999 0.25 ENST00000325617.5
CLGN
calmegin
chr7_-_86849883 0.25 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr16_+_31724552 0.24 ENST00000539915.1
ENST00000316491.9
ENST00000399681.3
ENST00000398696.3
ENST00000534369.1
ZNF720
zinc finger protein 720
chr17_-_45266542 0.24 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr5_-_98262240 0.24 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr15_-_55700522 0.23 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr11_-_95522907 0.23 ENST00000358780.5
ENST00000542135.1
FAM76B
family with sequence similarity 76, member B
chr4_-_69536346 0.22 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr8_-_12612962 0.22 ENST00000398246.3
LONRF1
LON peptidase N-terminal domain and ring finger 1
chr13_+_38923959 0.21 ENST00000379649.1
ENST00000239878.4
ENST00000437952.1
ENST00000379641.1
UFM1
ubiquitin-fold modifier 1
chr4_-_171012844 0.21 ENST00000502392.1
AADAT
aminoadipate aminotransferase
chrX_-_47509994 0.20 ENST00000343894.4
ELK1
ELK1, member of ETS oncogene family
chr19_+_42041860 0.20 ENST00000483481.2
ENST00000494375.2
AC006129.4
AC006129.4
chr20_+_44441304 0.20 ENST00000352551.5
UBE2C
ubiquitin-conjugating enzyme E2C
chr6_+_30687978 0.20 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr6_-_32095968 0.20 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr19_+_36346734 0.20 ENST00000586102.3
KIRREL2
kin of IRRE like 2 (Drosophila)
chr19_+_13001840 0.20 ENST00000222214.5
ENST00000589039.1
ENST00000591470.1
ENST00000457854.1
ENST00000422947.2
ENST00000588905.1
ENST00000587072.1
GCDH
glutaryl-CoA dehydrogenase
chr14_-_73925225 0.20 ENST00000356296.4
ENST00000355058.3
ENST00000359560.3
ENST00000557597.1
ENST00000554394.1
ENST00000555238.1
ENST00000535282.1
ENST00000555987.1
ENST00000555394.1
ENST00000554546.1
NUMB
numb homolog (Drosophila)
chr14_+_39944025 0.19 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr17_-_18266660 0.19 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr17_-_18266797 0.19 ENST00000316694.3
ENST00000539052.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr22_-_29137771 0.19 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr1_-_150669500 0.19 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr12_+_70574088 0.19 ENST00000552324.1
RP11-320P7.2
RP11-320P7.2
chr17_-_18266765 0.19 ENST00000354098.3
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr4_-_100242549 0.18 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr3_+_133292574 0.18 ENST00000264993.3
CDV3
CDV3 homolog (mouse)
chr6_+_64345698 0.18 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr13_+_73632897 0.18 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr5_+_159848854 0.18 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
PTTG1
pituitary tumor-transforming 1
chr14_-_51027838 0.17 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr6_-_39693111 0.17 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
KIF6
kinesin family member 6
chr6_+_36562132 0.17 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr3_+_51851612 0.17 ENST00000456080.1
IQCF3
IQ motif containing F3
chr18_-_67624160 0.17 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr11_+_119205222 0.17 ENST00000311413.4
RNF26
ring finger protein 26
chr2_+_172778952 0.17 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr1_+_62902308 0.16 ENST00000339950.4
USP1
ubiquitin specific peptidase 1
chr10_-_104001231 0.16 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr3_-_48659193 0.16 ENST00000330862.3
TMEM89
transmembrane protein 89
chr20_-_50418972 0.16 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr9_+_136501478 0.15 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr12_-_120966943 0.15 ENST00000552443.1
ENST00000547736.1
ENST00000445328.2
ENST00000547943.1
ENST00000288532.6
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr6_-_119256311 0.15 ENST00000316316.6
MCM9
minichromosome maintenance complex component 9
chr1_-_150849208 0.15 ENST00000358595.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr5_+_140557371 0.15 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr19_+_42041702 0.15 ENST00000487420.2
AC006129.4
AC006129.4
chr3_+_37284668 0.15 ENST00000361924.2
ENST00000444882.1
ENST00000356847.4
ENST00000450863.2
ENST00000429018.1
GOLGA4
golgin A4
chr17_-_38821373 0.15 ENST00000394052.3
KRT222
keratin 222
chr1_+_162336686 0.14 ENST00000420220.1
C1orf226
chromosome 1 open reading frame 226
chr6_-_135271219 0.14 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr15_-_75199213 0.14 ENST00000562698.1
FAM219B
family with sequence similarity 219, member B
chr4_-_70080449 0.13 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr8_+_110551925 0.13 ENST00000395785.2
EBAG9
estrogen receptor binding site associated, antigen, 9
chr7_+_142985308 0.13 ENST00000310447.5
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr5_-_137374288 0.13 ENST00000514310.1
FAM13B
family with sequence similarity 13, member B
chr16_+_2479390 0.13 ENST00000397066.4
CCNF
cyclin F
chr14_+_104182061 0.13 ENST00000216602.6
ZFYVE21
zinc finger, FYVE domain containing 21
chr6_-_135271260 0.12 ENST00000265605.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr4_-_174255400 0.12 ENST00000506267.1
HMGB2
high mobility group box 2
chr14_+_57671888 0.12 ENST00000391612.1
AL391152.1
AL391152.1
chr8_+_22132847 0.11 ENST00000521356.1
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr3_-_105587879 0.11 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr8_+_22132810 0.10 ENST00000356766.6
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr6_+_160542870 0.10 ENST00000324965.4
ENST00000457470.2
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr17_+_36508826 0.10 ENST00000580660.1
SOCS7
suppressor of cytokine signaling 7
chrX_-_21676442 0.10 ENST00000379499.2
KLHL34
kelch-like family member 34
chr21_+_35014829 0.10 ENST00000451686.1
ITSN1
intersectin 1 (SH3 domain protein)
chr5_-_159546396 0.10 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr15_-_58571445 0.10 ENST00000558231.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr4_+_108911036 0.10 ENST00000505878.1
HADH
hydroxyacyl-CoA dehydrogenase
chr7_+_142985467 0.10 ENST00000392925.2
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr3_-_160823040 0.10 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
B3GALNT1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr2_-_227050079 0.09 ENST00000423838.1
AC068138.1
AC068138.1
chr22_+_24322322 0.09 ENST00000215780.5
ENST00000402588.3
GSTT2
glutathione S-transferase theta 2
chr14_+_32798547 0.09 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_209602156 0.09 ENST00000429156.1
ENST00000366437.3
ENST00000603283.1
ENST00000431096.1
MIR205HG
MIR205 host gene (non-protein coding)
chr1_+_87595433 0.09 ENST00000469312.2
ENST00000490006.2
RP5-1052I5.1
long intergenic non-protein coding RNA 1140
chr2_+_135809835 0.08 ENST00000264158.8
ENST00000539493.1
ENST00000442034.1
ENST00000425393.1
RAB3GAP1
RAB3 GTPase activating protein subunit 1 (catalytic)
chr16_-_3493528 0.08 ENST00000301744.4
ZNF597
zinc finger protein 597
chr5_-_159846399 0.08 ENST00000297151.4
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr1_-_23670813 0.07 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr13_+_111748183 0.07 ENST00000422994.1
LINC00368
long intergenic non-protein coding RNA 368
chr9_+_104296243 0.07 ENST00000466817.1
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr1_-_68698197 0.07 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr10_-_99447024 0.07 ENST00000370626.3
AVPI1
arginine vasopressin-induced 1
chr19_+_1275917 0.06 ENST00000469144.1
C19orf24
chromosome 19 open reading frame 24
chr11_-_124981475 0.06 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr8_-_117886612 0.06 ENST00000520992.1
RAD21
RAD21 homolog (S. pombe)
chr10_+_91461413 0.06 ENST00000447580.1
KIF20B
kinesin family member 20B
chr17_-_74733404 0.06 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr16_+_3333443 0.06 ENST00000572748.1
ENST00000573578.1
ENST00000574253.1
ZNF263
zinc finger protein 263
chr8_+_21881636 0.06 ENST00000520125.1
ENST00000521157.1
ENST00000397940.1
ENST00000522813.1
NPM2
nucleophosmin/nucleoplasmin 2
chr2_+_242089833 0.05 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr1_+_40713573 0.05 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr11_-_118023490 0.05 ENST00000324727.4
SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr14_-_24711764 0.05 ENST00000557921.1
ENST00000558476.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr2_-_198540719 0.05 ENST00000295049.4
RFTN2
raftlin family member 2
chr3_+_111393501 0.05 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr22_+_17956618 0.05 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr10_-_1095050 0.05 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr11_-_111741994 0.05 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr4_+_40201954 0.04 ENST00000511121.1
RHOH
ras homolog family member H
chr6_-_10115007 0.04 ENST00000485268.1
OFCC1
orofacial cleft 1 candidate 1
chr6_+_36164487 0.04 ENST00000357641.6
BRPF3
bromodomain and PHD finger containing, 3
chr14_-_73924954 0.04 ENST00000555307.1
ENST00000554818.1
NUMB
numb homolog (Drosophila)
chr6_-_30080876 0.04 ENST00000376734.3
TRIM31
tripartite motif containing 31
chr1_+_220267429 0.04 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr14_+_91591873 0.04 ENST00000521064.1
C14orf159
chromosome 14 open reading frame 159
chr22_-_24303340 0.04 ENST00000404172.3
ENST00000290765.4
GSTT2B
glutathione S-transferase theta 2B (gene/pseudogene)
chr20_+_9494987 0.04 ENST00000427562.2
ENST00000246070.2
LAMP5
lysosomal-associated membrane protein family, member 5
chr3_-_113775328 0.04 ENST00000483766.1
ENST00000545063.1
ENST00000491000.1
ENST00000295878.3
KIAA1407
KIAA1407
chr1_-_23670752 0.04 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr8_+_9413410 0.04 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr1_-_36916011 0.03 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
OSCP1
organic solute carrier partner 1
chr1_+_151735431 0.03 ENST00000321531.5
ENST00000315067.8
OAZ3
ornithine decarboxylase antizyme 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ISX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.4 1.5 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.3 0.9 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 0.6 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.2 0.6 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.2 1.1 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 2.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 0.2 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 1.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 0.5 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 0.6 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.4 GO:0050993 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.1 0.2 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.2 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.7 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.3 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.2 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.1 0.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.4 GO:0019236 response to pheromone(GO:0019236)
0.0 0.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.5 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.2 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.7 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) L-kynurenine metabolic process(GO:0097052)
0.0 1.2 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.0 0.3 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 1.1 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:1903371 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 1.4 GO:0006505 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0035234 luteolysis(GO:0001554) ectopic germ cell programmed cell death(GO:0035234)
0.0 0.3 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 1.5 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.7 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.4 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.2 GO:0006568 tryptophan metabolic process(GO:0006568)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.0 0.1 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0006069 ethanol oxidation(GO:0006069)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.1 1.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.9 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.4 GO:0019031 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.1 1.1 GO:0070938 contractile ring(GO:0070938)
0.1 0.2 GO:1990923 PET complex(GO:1990923)
0.0 0.5 GO:0033503 HULC complex(GO:0033503)
0.0 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 2.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0042584 chromaffin granule membrane(GO:0042584)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0070905 serine binding(GO:0070905)
0.2 0.6 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.2 0.6 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.2 2.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.6 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.1 0.7 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.6 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.1 0.5 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.1 0.4 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.1 0.5 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.1 0.2 GO:0047536 2-aminoadipate transaminase activity(GO:0047536)
0.1 1.5 GO:0043295 glutathione binding(GO:0043295)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.2 GO:0034584 piRNA binding(GO:0034584)
0.0 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.4 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.0 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0 0.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.5 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.6 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.8 GO:0004177 aminopeptidase activity(GO:0004177)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway