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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for IRX5
Z-value: 1.38
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Transcription factors associated with IRX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX5 | hg19_v2_chr16_+_54964740_54964789 | 0.31 | 6.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_141264597 Show fit | 3.93 |
ENST00000338517.4
ENST00000394203.3 ENST00000506322.1 |
short coiled-coil protein |
|
| chr2_+_38177575 Show fit | 1.60 |
ENST00000407257.1
ENST00000417700.2 ENST00000234195.3 ENST00000442857.1 |
regulator of microtubule dynamics 2 |
|
| chr12_+_56114151 Show fit | 1.48 |
ENST00000547072.1
ENST00000552930.1 ENST00000257895.5 |
retinol dehydrogenase 5 (11-cis/9-cis) |
|
| chr7_-_16844611 Show fit | 1.19 |
ENST00000401412.1
ENST00000419304.2 |
anterior gradient 2 |
|
| chr12_+_56114189 Show fit | 1.18 |
ENST00000548082.1
|
retinol dehydrogenase 5 (11-cis/9-cis) |
|
| chr17_+_14277419 Show fit | 1.14 |
ENST00000436469.1
|
AC022816.2 |
|
| chr1_+_63989004 Show fit | 1.07 |
ENST00000371088.4
|
EF-hand calcium binding domain 7 |
|
| chr10_-_18944123 Show fit | 1.06 |
ENST00000606425.1
|
Uncharacterized protein |
|
| chr6_+_26204825 Show fit | 1.06 |
ENST00000360441.4
|
histone cluster 1, H4e |
|
| chr7_+_23210760 Show fit | 1.04 |
ENST00000366347.4
|
Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.9 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 2.0 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 1.5 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.0 | 1.3 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.2 | 1.2 | GO:1903899 | lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.0 | 1.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 1.1 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.3 | 1.0 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.1 | 1.0 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.2 | 0.9 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 1.1 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.0 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 1.0 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 0.9 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.9 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 0.8 | GO:0034680 | integrin alpha10-beta1 complex(GO:0034680) |
| 0.1 | 0.8 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.8 | GO:0043234 | macromolecular complex(GO:0032991) protein complex(GO:0043234) |
| 0.0 | 0.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.1 | 1.2 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 1.2 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 1.0 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 0.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.3 | 0.8 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.1 | 0.8 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.0 | 0.8 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 0.8 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.3 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |