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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for IRF9
Z-value: 10.71
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Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 0.99 | 8.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_42798094 Show fit | 64.03 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr12_-_121477039 Show fit | 49.68 |
ENST00000257570.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr12_-_121476959 Show fit | 45.01 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr21_+_42798124 Show fit | 40.10 |
ENST00000417963.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr1_+_948803 Show fit | 39.07 |
ENST00000379389.4
|
ISG15 ubiquitin-like modifier |
|
| chr2_-_7005785 Show fit | 35.63 |
ENST00000256722.5
ENST00000404168.1 ENST00000458098.1 |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
|
| chr21_+_42798158 Show fit | 34.98 |
ENST00000441677.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr21_+_42797958 Show fit | 34.04 |
ENST00000419044.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr17_+_6659153 Show fit | 32.55 |
ENST00000441631.1
ENST00000438512.1 ENST00000346752.4 ENST00000361842.3 |
XIAP associated factor 1 |
|
| chr1_+_79115503 Show fit | 31.69 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
interferon-induced protein 44 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 277.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 9.6 | 201.1 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 6.2 | 74.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 3.9 | 54.5 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 13.5 | 54.0 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 4.6 | 50.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 4.9 | 49.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 11.9 | 47.6 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 1.9 | 46.5 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 43.9 | GO:0009615 | response to virus(GO:0009615) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 213.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 186.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 174.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 163.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.2 | 38.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 4.0 | 27.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 26.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.3 | 24.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.2 | 16.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.7 | 16.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.2 | 218.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.4 | 201.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.3 | 82.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.5 | 74.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 1.9 | 50.3 | GO:0070403 | NAD+ binding(GO:0070403) |
| 2.2 | 49.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 3.0 | 38.4 | GO:0031386 | protein tag(GO:0031386) |
| 8.9 | 35.6 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 3.5 | 35.0 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 30.9 | GO:0042802 | identical protein binding(GO:0042802) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.5 | 27.9 | PID MYC PATHWAY | C-MYC pathway |
| 1.7 | 23.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 13.6 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 9.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 8.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 6.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.9 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 2.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 667.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 5.0 | 80.4 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.7 | 35.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.5 | 27.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 22.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 11.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 5.9 | REACTOME INTERFERON SIGNALING | Genes involved in Interferon Signaling |
| 1.3 | 5.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 3.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.8 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |