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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRF9

Z-value: 10.71

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.998.4e-03Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42798094 64.03 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_-_121477039 49.68 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_121476959 45.01 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr21_+_42798124 40.10 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_+_948803 39.07 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr2_-_7005785 35.63 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr21_+_42798158 34.98 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42797958 34.04 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr17_+_6659153 32.55 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr1_+_79115503 31.69 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr10_+_91092241 29.60 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42733870 27.93 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_-_121476750 27.51 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr19_+_16254488 27.04 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr11_-_615570 26.81 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr10_+_91061712 24.87 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr9_-_32526184 23.90 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_+_79086088 23.87 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr12_+_113344582 22.54 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_+_113344811 21.27 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_615942 20.80 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr12_+_113344755 19.79 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr22_+_18632666 19.12 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr12_+_113376249 18.55 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr4_+_89378261 18.47 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr12_-_56753858 18.02 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr3_-_122283424 17.31 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283100 16.87 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr2_-_55920952 16.22 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr3_-_122283079 16.14 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr4_-_169401628 15.60 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr2_+_7005959 14.99 ENST00000442639.1
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_+_158979680 14.79 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr2_-_163175133 14.70 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr1_+_158979686 14.27 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979792 14.26 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr17_-_54991369 14.26 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr12_+_113376157 14.12 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr9_-_32526299 14.09 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_+_94577074 13.59 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr15_+_74287035 13.51 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr17_-_54991395 13.46 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr2_+_7017796 11.41 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr19_-_17516449 11.18 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr17_+_6659354 10.38 ENST00000574907.1
XAF1
XIAP associated factor 1
chr15_+_74287118 10.26 ENST00000563500.1
PML
promyelocytic leukemia
chr3_+_187086120 10.23 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr3_+_122283064 10.08 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr19_+_10196981 10.03 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr6_-_31324943 9.97 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr3_-_146262365 9.94 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr3_-_146262352 9.66 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr2_-_152146385 9.62 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr11_-_4414880 9.37 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr11_+_5646213 9.34 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr6_+_37400974 9.27 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr3_-_146262428 9.23 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr7_+_134832808 9.14 ENST00000275767.3
TMEM140
transmembrane protein 140
chr3_-_146262637 8.90 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr11_-_57334732 8.88 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr3_+_122399444 8.34 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr10_+_91174486 8.30 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr10_+_91174314 7.73 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr11_-_57335280 7.62 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr3_-_146262488 7.36 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr2_-_106810783 7.26 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr2_-_106810742 7.07 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chr1_-_150738261 6.23 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr17_+_78234625 6.19 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr6_-_32806483 6.07 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_37384175 5.89 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr6_-_32806506 5.66 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr14_+_24630465 5.49 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr13_+_50070077 5.03 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr13_+_50070491 4.43 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr15_+_74287009 4.14 ENST00000395135.3
PML
promyelocytic leukemia
chr3_-_146262293 4.00 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr16_-_74734672 3.78 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr15_-_26108355 3.70 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr17_+_6658878 3.62 ENST00000574394.1
XAF1
XIAP associated factor 1
chr4_-_169239921 3.55 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr8_+_39770803 3.15 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr3_+_122283175 2.83 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr3_+_122399697 2.82 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr17_-_4167142 2.70 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr2_+_33701707 2.52 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_+_126240442 2.14 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr10_-_95241951 2.08 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr10_-_95242044 1.97 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr1_-_154580616 1.88 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr17_-_40264692 1.80 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr5_-_95297534 1.37 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr4_+_186990298 1.27 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr6_-_110736742 1.27 ENST00000368924.3
ENST00000368923.3
DDO
D-aspartate oxidase
chr17_-_74489215 1.13 ENST00000585701.1
ENST00000591192.1
ENST00000589526.1
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr6_+_106546808 1.10 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr3_-_28390415 1.00 ENST00000414162.1
ENST00000420543.2
AZI2
5-azacytidine induced 2
chr9_+_33265011 0.66 ENST00000419016.2
CHMP5
charged multivesicular body protein 5
chr4_-_147442982 0.63 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr3_-_141747439 0.59 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_59481406 0.24 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_61436146 0.18 ENST00000290291.6
OGFR
opioid growth factor receptor
chr2_+_7073174 0.16 ENST00000416587.1
RNF144A
ring finger protein 144A
chr1_+_66820058 0.11 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_-_142166796 0.05 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chr18_-_67624160 0.05 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
13.5 54.0 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
11.9 47.6 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
9.6 201.1 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
8.9 35.6 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
6.2 74.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
5.4 16.2 GO:2000625 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
4.9 49.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
4.8 14.3 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
4.6 50.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
4.4 26.4 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
3.9 11.7 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
3.9 54.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
3.7 11.2 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
3.5 27.9 GO:0030578 PML body organization(GO:0030578)
3.2 277.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
3.1 9.3 GO:0036451 cap mRNA methylation(GO:0036451)
2.5 27.0 GO:1904180 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
2.4 9.6 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
2.3 9.4 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
1.9 46.5 GO:0035456 response to interferon-beta(GO:0035456)
1.5 6.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.5 27.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
1.1 3.2 GO:0036269 swimming behavior(GO:0036269)
1.0 8.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
1.0 37.1 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.9 5.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.7 19.1 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.5 2.7 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.4 1.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.3 4.1 GO:0001778 plasma membrane repair(GO:0001778)
0.3 7.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 9.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.2 13.1 GO:0070206 protein trimerization(GO:0070206)
0.2 6.2 GO:0010447 response to acidic pH(GO:0010447)
0.1 1.3 GO:0007320 insemination(GO:0007320)
0.1 3.7 GO:0045332 phospholipid translocation(GO:0045332)
0.1 43.9 GO:0009615 response to virus(GO:0009615)
0.1 2.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.0 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 27.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.4 9.8 GO:0042825 TAP complex(GO:0042825)
1.2 16.2 GO:0042788 polysomal ribosome(GO:0042788)
0.9 6.2 GO:0036021 endolysosome lumen(GO:0036021)
0.8 8.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.7 16.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 3.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 186.2 GO:0031965 nuclear membrane(GO:0031965)
0.3 1.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.3 24.8 GO:0005643 nuclear pore(GO:0005643)
0.2 2.7 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 26.4 GO:0005811 lipid particle(GO:0005811)
0.2 38.0 GO:0032587 ruffle membrane(GO:0032587)
0.2 11.2 GO:0005771 multivesicular body(GO:0005771)
0.1 213.3 GO:0005730 nucleolus(GO:0005730)
0.1 14.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 8.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 174.1 GO:0005739 mitochondrion(GO:0005739)
0.0 1.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.3 GO:0036020 endolysosome membrane(GO:0036020)
0.0 5.9 GO:0005840 ribosome(GO:0005840)
0.0 163.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 3.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
18.2 218.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
8.9 35.6 GO:0009041 uridylate kinase activity(GO:0009041)
4.8 14.3 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
3.5 35.0 GO:0042296 ISG15 transferase activity(GO:0042296)
3.1 9.3 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
3.0 38.4 GO:0031386 protein tag(GO:0031386)
2.6 10.2 GO:0031849 olfactory receptor binding(GO:0031849)
2.3 16.2 GO:0034046 poly(G) binding(GO:0034046)
2.2 49.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
2.0 9.8 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
1.9 50.3 GO:0070403 NAD+ binding(GO:0070403)
1.2 27.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
1.0 5.9 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.8 3.2 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.5 74.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.5 13.2 GO:0032183 SUMO binding(GO:0032183)
0.4 26.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.4 201.1 GO:0008017 microtubule binding(GO:0008017)
0.4 13.6 GO:0005521 lamin binding(GO:0005521)
0.4 11.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 11.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 10.0 GO:0042605 peptide antigen binding(GO:0042605)
0.3 82.3 GO:0001047 core promoter binding(GO:0001047)
0.2 27.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 6.2 GO:0043394 proteoglycan binding(GO:0043394)
0.1 19.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 3.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 15.6 GO:0004386 helicase activity(GO:0004386)
0.1 1.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 12.9 GO:0042393 histone binding(GO:0042393)
0.0 2.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 18.4 GO:0005525 GTP binding(GO:0005525)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 30.9 GO:0042802 identical protein binding(GO:0042802)
0.0 6.2 GO:0016887 ATPase activity(GO:0016887)
0.0 2.7 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 4.1 GO:0005543 phospholipid binding(GO:0005543)
0.0 13.3 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 23.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 27.9 PID MYC PATHWAY C-MYC pathway
0.2 32.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 9.5 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 13.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 5.9 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 8.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 6.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 667.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
5.0 80.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.3 5.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.7 35.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.5 27.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.4 11.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 22.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 5.9 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.0 1.8 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways