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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRF6_IRF4_IRF5

Z-value: 6.57

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 interferon regulatory factor 6
IRF4
ENSG00000137265.10 interferon regulatory factor 4
IRF5
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF6hg19_v2_chr1_-_209979375_209979389-0.782.2e-01Click!
IRF5hg19_v2_chr7_+_128577972_128578047-0.564.4e-01Click!
IRF4hg19_v2_chr6_+_391739_391759-0.217.9e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42792442 21.56 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615942 20.61 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr19_+_16254488 19.74 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr11_-_321050 18.29 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr21_+_42798094 17.55 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr9_-_32526299 16.96 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_32526184 15.63 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_113344582 14.00 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr8_+_8559406 13.83 ENST00000519106.1
CLDN23
claudin 23
chr12_+_113344811 12.49 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_7005785 12.45 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr12_+_113344755 11.99 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798124 10.36 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr3_-_146262365 9.97 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr11_+_5710919 9.83 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr3_-_146262352 9.48 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr12_+_113376249 9.29 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr11_-_615570 9.23 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr17_+_6659153 9.10 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr3_-_146262428 9.03 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr9_-_100881466 8.77 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr21_+_42797958 8.75 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr3_-_146262637 8.65 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr21_+_42798158 8.57 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_+_948803 8.52 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr11_-_321340 7.84 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr11_+_5711010 7.76 ENST00000454828.1
TRIM22
tripartite motif containing 22
chr20_-_62203808 7.66 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr3_-_122283100 7.40 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283424 7.38 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_146262488 7.27 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr21_+_42733870 7.21 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_+_113376157 7.21 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_122283079 7.04 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr10_+_91061712 6.14 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr19_+_10196981 6.10 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr4_+_89378261 6.07 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr2_-_55920952 6.05 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr11_-_57335280 6.03 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr2_+_7017796 5.56 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr2_-_191878874 5.21 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191878681 5.18 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr15_+_74287035 5.03 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr2_-_37384175 4.57 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr3_-_182880541 4.44 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr3_+_122283064 4.26 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr17_+_25958174 4.21 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr12_-_56753858 3.98 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr3_+_187086120 3.97 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr3_-_146262293 3.88 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr4_+_69917078 3.81 ENST00000502942.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr15_+_74287118 3.70 ENST00000563500.1
PML
promyelocytic leukemia
chr19_+_10196781 3.59 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr22_+_18632666 3.51 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr7_-_138794394 3.46 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr12_+_75874580 3.23 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr2_-_163175133 3.18 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr17_-_54991369 3.13 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr10_+_91174314 3.13 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr14_+_94577074 3.07 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr2_+_7005959 2.98 ENST00000442639.1
RSAD2
radical S-adenosyl methionine domain containing 2
chr17_-_54991395 2.88 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr12_+_75874460 2.82 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr16_+_3068393 2.77 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chrX_+_23801280 2.73 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr7_-_33080506 2.72 ENST00000381626.2
ENST00000409467.1
ENST00000449201.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr8_+_23386557 2.64 ENST00000523930.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr12_+_75874984 2.55 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr17_+_40118773 2.50 ENST00000472031.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr12_+_52643077 2.45 ENST00000553310.2
ENST00000544024.1
KRT86
keratin 86
chr11_-_57334732 2.44 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr15_+_43425672 2.39 ENST00000260403.2
TMEM62
transmembrane protein 62
chr17_+_40118805 2.19 ENST00000591072.1
ENST00000587679.1
ENST00000393888.1
ENST00000441615.2
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr22_+_36044411 2.15 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr2_-_106810783 1.98 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr17_+_6659354 1.94 ENST00000574907.1
XAF1
XIAP associated factor 1
chr9_+_112542572 1.84 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr17_+_40118759 1.82 ENST00000393892.3
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr9_+_95820966 1.82 ENST00000375472.3
ENST00000465709.1
SUSD3
sushi domain containing 3
chr16_+_29127282 1.81 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr2_-_106810742 1.80 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chr15_+_83478370 1.79 ENST00000286760.4
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr14_+_105266933 1.75 ENST00000555360.1
ZBTB42
zinc finger and BTB domain containing 42
chr10_+_91174486 1.67 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chrM_+_9207 1.60 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_+_160693591 1.60 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr7_-_130597935 1.54 ENST00000447307.1
ENST00000418546.1
MIR29B1
microRNA 29a
chr17_-_39677971 1.53 ENST00000393976.2
KRT15
keratin 15
chr19_-_17516449 1.49 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr17_+_78234625 1.45 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr6_+_53794780 1.34 ENST00000505762.1
ENST00000511369.1
ENST00000431554.2
MLIP
RP11-411K7.1
muscular LMNA-interacting protein
RP11-411K7.1
chr17_-_4167142 1.34 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr16_-_74734672 1.33 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr3_+_122283175 1.29 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr10_+_75668916 1.28 ENST00000481390.1
PLAU
plasminogen activator, urokinase
chr8_+_39972170 1.26 ENST00000521257.1
RP11-359E19.2
RP11-359E19.2
chr7_-_138794081 1.25 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr16_+_30751953 1.25 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr8_+_72755367 1.22 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr10_+_71561630 1.22 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr1_-_238108575 1.16 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr1_-_168464875 1.15 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr1_-_78225374 1.15 ENST00000524536.1
USP33
ubiquitin specific peptidase 33
chr17_-_26903900 1.13 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC
aldolase C, fructose-bisphosphate
chr9_+_112542591 1.11 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr15_+_74287009 1.07 ENST00000395135.3
PML
promyelocytic leukemia
chr19_+_7600584 1.05 ENST00000600737.1
PNPLA6
patatin-like phospholipase domain containing 6
chr15_-_75748115 1.01 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr9_-_133814527 0.97 ENST00000451466.1
FIBCD1
fibrinogen C domain containing 1
chr7_-_150779995 0.96 ENST00000462940.1
ENST00000492838.1
ENST00000392818.3
ENST00000488752.1
ENST00000476627.1
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr17_-_7164410 0.92 ENST00000574070.1
CLDN7
claudin 7
chrX_-_110655391 0.92 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr20_-_45318230 0.92 ENST00000372114.3
TP53RK
TP53 regulating kinase
chr17_-_76778339 0.91 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr9_+_125512019 0.90 ENST00000373684.1
ENST00000304720.2
OR1L6
olfactory receptor, family 1, subfamily L, member 6
chr11_+_130184888 0.88 ENST00000602376.1
ENST00000532116.3
ENST00000602310.1
RP11-121M22.1
RP11-121M22.1
chr12_-_109797249 0.85 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chrM_+_10053 0.85 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr17_+_18380051 0.82 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr22_-_31688431 0.82 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr15_-_30114231 0.80 ENST00000356107.6
ENST00000545208.2
TJP1
tight junction protein 1
chr2_-_32390801 0.79 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr1_-_44497024 0.77 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_-_62653903 0.75 ENST00000552075.1
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr14_-_103989033 0.74 ENST00000553878.1
ENST00000557530.1
CKB
creatine kinase, brain
chr1_-_8000872 0.74 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr7_-_100895414 0.73 ENST00000435848.1
ENST00000474120.1
FIS1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr10_+_71562180 0.73 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr15_+_23810853 0.73 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr2_-_127977654 0.72 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr11_-_47736896 0.71 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
AGBL2
ATP/GTP binding protein-like 2
chr1_+_205197304 0.69 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr19_-_48389651 0.68 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr19_+_18942720 0.68 ENST00000262803.5
UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr17_-_39890893 0.66 ENST00000393939.2
ENST00000347901.4
ENST00000341193.5
ENST00000310778.5
HAP1
huntingtin-associated protein 1
chr15_-_26108355 0.66 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr12_-_31477072 0.65 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr10_+_71561649 0.62 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr19_+_18942761 0.61 ENST00000599848.1
UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr7_-_77045617 0.61 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr11_+_65554493 0.59 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr4_-_83295296 0.58 ENST00000507010.1
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr5_+_178286925 0.58 ENST00000322434.3
ZNF354B
zinc finger protein 354B
chr17_+_78965624 0.57 ENST00000325167.5
CHMP6
charged multivesicular body protein 6
chr4_-_129208030 0.57 ENST00000503872.1
PGRMC2
progesterone receptor membrane component 2
chr11_+_128563652 0.56 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr12_-_51663682 0.56 ENST00000603838.1
SMAGP
small cell adhesion glycoprotein
chr19_+_57905551 0.55 ENST00000597410.1
AC004076.7
AC004076.7
chr22_-_31688381 0.55 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr11_+_44748361 0.55 ENST00000533202.1
ENST00000533080.1
ENST00000520358.2
ENST00000520999.2
TSPAN18
tetraspanin 18
chr6_+_126070726 0.55 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr13_+_24144796 0.54 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr20_-_47894936 0.53 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr12_+_54402790 0.53 ENST00000040584.4
HOXC8
homeobox C8
chr5_-_79946820 0.50 ENST00000604882.1
MTRNR2L2
MT-RNR2-like 2
chr12_-_104350898 0.50 ENST00000552940.1
ENST00000547975.1
ENST00000549478.1
ENST00000546540.1
ENST00000546819.1
ENST00000378090.4
ENST00000547945.1
C12orf73
chromosome 12 open reading frame 73
chr13_+_103498143 0.49 ENST00000535557.1
ERCC5
excision repair cross-complementing rodent repair deficiency, complementation group 5
chr7_+_141478242 0.48 ENST00000247881.2
TAS2R4
taste receptor, type 2, member 4
chr1_-_44497118 0.47 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_+_24528108 0.46 ENST00000438429.1
KIAA1217
KIAA1217
chr1_+_78354330 0.46 ENST00000440324.1
NEXN
nexilin (F actin binding protein)
chr19_-_50528392 0.45 ENST00000600137.1
ENST00000597215.1
VRK3
vaccinia related kinase 3
chr11_+_809647 0.44 ENST00000321153.4
RPLP2
ribosomal protein, large, P2
chr2_+_217277137 0.44 ENST00000430374.1
ENST00000357276.4
ENST00000444508.1
SMARCAL1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr8_+_92261516 0.42 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr4_-_11431188 0.42 ENST00000510712.1
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr12_+_53491220 0.42 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr14_-_23564320 0.41 ENST00000605057.1
ACIN1
apoptotic chromatin condensation inducer 1
chr5_+_133706865 0.41 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr22_-_31885727 0.41 ENST00000330125.5
ENST00000344710.5
ENST00000397518.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr18_+_22006646 0.41 ENST00000585067.1
ENST00000578221.1
IMPACT
impact RWD domain protein
chr14_+_23563952 0.39 ENST00000319074.4
C14orf119
chromosome 14 open reading frame 119
chr19_-_4723761 0.39 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
DPP9
dipeptidyl-peptidase 9
chr19_+_11466167 0.39 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr3_-_185655795 0.38 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr7_+_151038850 0.38 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1
negative regulator of ubiquitin-like proteins 1
chr6_-_94129244 0.37 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr1_-_52344471 0.37 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr17_+_22022437 0.36 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr19_+_55897297 0.35 ENST00000431533.2
ENST00000428193.2
ENST00000558815.1
ENST00000560583.1
ENST00000560055.1
ENST00000559463.1
RPL28
ribosomal protein L28
chr12_+_31477250 0.35 ENST00000313737.4
AC024940.1
AC024940.1
chr19_-_50528584 0.35 ENST00000594092.1
ENST00000443401.2
ENST00000594948.1
ENST00000377011.2
ENST00000593919.1
ENST00000601324.1
ENST00000316763.3
ENST00000601341.1
ENST00000600259.1
VRK3
vaccinia related kinase 3
chr13_+_98794810 0.35 ENST00000595437.1
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr7_-_107883678 0.34 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr11_-_10530723 0.34 ENST00000536684.1
MTRNR2L8
MT-RNR2-like 8
chr12_+_121131970 0.34 ENST00000535656.1
MLEC
malectin
chr21_+_47268058 0.34 ENST00000400310.1
PCBP3
poly(rC) binding protein 3
chr2_-_158184211 0.33 ENST00000397283.2
ERMN
ermin, ERM-like protein
chr15_-_30113676 0.33 ENST00000400011.2
TJP1
tight junction protein 1
chr3_+_154797781 0.32 ENST00000382989.3
MME
membrane metallo-endopeptidase
chr17_-_59668550 0.32 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr5_-_176057518 0.32 ENST00000393693.2
SNCB
synuclein, beta
chr1_-_160990886 0.32 ENST00000537746.1
F11R
F11 receptor
chr4_-_83295103 0.32 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr16_+_68119247 0.32 ENST00000575270.1
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr6_+_3118926 0.32 ENST00000380379.5
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr11_-_85522172 0.31 ENST00000316356.4
ENST00000389960.4
ENST00000527523.1
SYTL2
synaptotagmin-like 2
chr11_-_66056596 0.31 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr11_-_2162468 0.30 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_+_44771088 0.29 ENST00000396048.2
ZNF501
zinc finger protein 501

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 35.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
7.5 29.8 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
4.8 48.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
3.5 74.0 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
3.1 12.5 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
2.6 10.4 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
2.4 26.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
2.0 6.1 GO:2000627 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
1.9 23.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.8 19.7 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
1.4 8.5 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
1.4 4.2 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.4 42.8 GO:0035455 response to interferon-alpha(GO:0035455)
1.4 16.5 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.3 3.8 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
1.2 9.8 GO:0030578 PML body organization(GO:0030578)
0.9 2.7 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.9 2.6 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.6 1.3 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.6 59.5 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.4 1.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 1.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 10.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3 0.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.3 0.9 GO:1904586 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.3 8.8 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 1.1 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.3 1.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 6.0 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 19.2 GO:0070206 protein trimerization(GO:0070206)
0.2 0.7 GO:1990910 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) response to hypobaric hypoxia(GO:1990910)
0.2 2.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.2 1.3 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.2 0.7 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.2 0.6 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 0.5 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.2 2.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.2 3.8 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.7 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 0.7 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 5.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 6.5 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.1 4.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 2.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.3 GO:0006382 adenosine to inosine editing(GO:0006382) IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.1 0.3 GO:0036269 swimming behavior(GO:0036269)
0.1 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 1.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.8 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 0.3 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of meiosis I(GO:0060903)
0.1 0.2 GO:0001172 transcription, RNA-templated(GO:0001172)
0.1 0.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 0.2 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.4 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.9 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.3 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 2.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.5 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.8 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.0 1.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.7 GO:0042574 retinal metabolic process(GO:0042574)
0.0 3.8 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:1903027 regulation of opsonization(GO:1903027)
0.0 0.4 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.4 GO:0072178 nephric duct morphogenesis(GO:0072178)
0.0 0.2 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.1 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.5 GO:0010225 response to UV-C(GO:0010225)
0.0 0.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.3 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.6 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 11.6 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.4 GO:0006825 copper ion transport(GO:0006825)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.1 4.4 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.7 2.6 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.5 6.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.5 6.1 GO:0042788 polysomal ribosome(GO:0042788)
0.2 1.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 17.3 GO:0015030 Cajal body(GO:0015030)
0.2 45.4 GO:0005923 bicellular tight junction(GO:0005923)
0.2 1.3 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 4.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 1.1 GO:0030891 VCB complex(GO:0030891)
0.1 0.9 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 56.6 GO:0031965 nuclear membrane(GO:0031965)
0.1 7.2 GO:0005643 nuclear pore(GO:0005643)
0.1 44.4 GO:0045121 membrane raft(GO:0045121)
0.1 1.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 7.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 8.5 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.1 0.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 0.4 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 25.2 GO:0010008 endosome membrane(GO:0010008)
0.0 2.4 GO:0045095 keratin filament(GO:0045095)
0.0 70.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 5.1 GO:0005840 ribosome(GO:0005840)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 1.9 GO:0005635 nuclear envelope(GO:0005635)
0.0 6.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 55.0 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
3.1 12.5 GO:0009041 uridylate kinase activity(GO:0009041)
2.2 48.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.6 6.5 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
1.5 14.5 GO:0042296 ISG15 transferase activity(GO:0042296)
1.3 3.8 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
1.1 4.2 GO:0048030 disaccharide binding(GO:0048030)
1.0 4.0 GO:0031849 olfactory receptor binding(GO:0031849)
1.0 26.5 GO:0070403 NAD+ binding(GO:0070403)
0.9 2.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.9 6.1 GO:0034046 poly(G) binding(GO:0034046)
0.8 4.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.6 7.8 GO:0031386 protein tag(GO:0031386)
0.5 2.7 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.5 1.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 1.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.3 8.4 GO:0032183 SUMO binding(GO:0032183)
0.3 35.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 6.0 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 10.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 0.7 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 21.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 74.8 GO:0008017 microtubule binding(GO:0008017)
0.2 4.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 8.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 2.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 17.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.7 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 1.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 3.1 GO:0005521 lamin binding(GO:0005521)
0.1 7.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 17.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.7 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 3.8 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.3 GO:0008061 chitin binding(GO:0008061)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.5 GO:0000405 bubble DNA binding(GO:0000405)
0.1 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.2 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.4 GO:0097617 annealing helicase activity(GO:0036310) annealing activity(GO:0097617)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505) 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.0 0.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 1.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.6 GO:0008289 lipid binding(GO:0008289)
0.0 0.2 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 3.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 1.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.1 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 14.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 9.9 PID MYC PATHWAY C-MYC pathway
0.2 27.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 2.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.5 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 71.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
2.2 201.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 13.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 9.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 4.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 8.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis