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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for IRF6_IRF4_IRF5
Z-value: 6.57
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Transcription factors associated with IRF6_IRF4_IRF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF6 | hg19_v2_chr1_-_209979375_209979389 | -0.78 | 2.2e-01 | Click! |
| IRF5 | hg19_v2_chr7_+_128577972_128578047 | -0.56 | 4.4e-01 | Click! |
| IRF4 | hg19_v2_chr6_+_391739_391759 | -0.21 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_42792442 Show fit | 21.56 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr11_-_615942 Show fit | 20.61 |
ENST00000397562.3
ENST00000330243.5 ENST00000397570.1 ENST00000397574.2 |
interferon regulatory factor 7 |
|
| chr19_+_16254488 Show fit | 19.74 |
ENST00000588246.1
ENST00000593031.1 |
hematopoietic SH2 domain containing |
|
| chr11_-_321050 Show fit | 18.29 |
ENST00000399808.4
|
interferon induced transmembrane protein 3 |
|
| chr21_+_42798094 Show fit | 17.55 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr9_-_32526299 Show fit | 16.96 |
ENST00000379882.1
ENST00000379883.2 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
|
| chr9_-_32526184 Show fit | 15.63 |
ENST00000545044.1
ENST00000379868.1 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
|
| chr12_+_113344582 Show fit | 14.00 |
ENST00000202917.5
ENST00000445409.2 ENST00000452357.2 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr8_+_8559406 Show fit | 13.83 |
ENST00000519106.1
|
claudin 23 |
|
| chr12_+_113344811 Show fit | 12.49 |
ENST00000551241.1
ENST00000553185.1 ENST00000550689.1 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 74.0 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.6 | 59.5 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 4.8 | 48.3 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 1.4 | 42.8 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 8.9 | 35.8 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 7.5 | 29.8 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 2.4 | 26.5 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.9 | 23.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.8 | 19.7 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 0.2 | 19.2 | GO:0070206 | protein trimerization(GO:0070206) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 70.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 56.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 45.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 44.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 25.2 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.2 | 17.3 | GO:0015030 | Cajal body(GO:0015030) |
| 1.4 | 9.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 8.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 7.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 7.2 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 74.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 4.6 | 55.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 2.2 | 48.3 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.3 | 35.9 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 1.0 | 26.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.2 | 21.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 17.6 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 17.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.5 | 14.5 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 3.1 | 12.5 | GO:0009041 | uridylate kinase activity(GO:0009041) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.0 | 14.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.2 | 9.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 2.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.5 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 2.0 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 201.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 3.3 | 71.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.3 | 13.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 9.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 8.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 4.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 2.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 1.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |