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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 7.23

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50168861_501688730.802.0e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_91087651 35.55 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91092241 29.32 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_948803 26.64 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr21_+_42792442 22.07 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_+_91061712 19.38 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr12_+_113416191 19.34 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr1_+_79115503 16.85 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr2_-_163175133 16.69 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr19_+_39786962 14.99 ENST00000333625.2
IFNL1
interferon, lambda 1
chr16_-_11350036 14.74 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chr12_+_113416265 14.09 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr7_-_92747269 13.76 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr11_-_615570 13.60 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr12_+_113376249 12.85 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr7_-_92777606 11.36 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr2_-_231084659 10.52 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr11_-_615942 10.47 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr2_-_231084820 10.39 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr4_-_169401628 10.21 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr22_+_18632666 10.10 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr22_+_36649056 9.81 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr4_+_89378261 9.73 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr12_+_113376157 9.67 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_122283424 8.89 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr22_+_36649170 8.62 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr3_-_122283100 8.51 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr2_+_218933972 8.41 ENST00000374155.3
RUFY4
RUN and FYVE domain containing 4
chr3_-_172241250 8.34 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr6_+_32821924 8.24 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr3_-_122283079 8.22 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr7_-_139756791 8.19 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr6_-_32821599 8.08 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr20_-_47894569 7.95 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr2_-_231084617 7.69 ENST00000409815.2
SP110
SP110 nuclear body protein
chr19_+_10196781 7.62 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr17_+_6659153 7.52 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr22_-_36635684 7.45 ENST00000358502.5
APOL2
apolipoprotein L, 2
chr22_-_36635563 7.06 ENST00000451256.2
APOL2
apolipoprotein L, 2
chr3_+_122399444 7.04 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr11_-_4414880 6.94 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr22_-_36635598 6.74 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr11_-_57334732 6.66 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr22_-_36635225 6.64 ENST00000529194.1
APOL2
apolipoprotein L, 2
chr9_+_5450503 6.43 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr9_-_32526299 6.15 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_+_187086120 5.62 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr22_+_36044411 5.61 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr9_-_32526184 5.47 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_14369524 5.26 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr19_-_17516449 5.04 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr3_+_122283064 5.01 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr20_+_388791 4.83 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr2_-_73869508 4.72 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr22_-_36556821 4.71 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr4_-_169239921 4.70 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr6_-_32806506 4.61 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr19_+_10196981 4.56 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr6_-_36355513 4.55 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chr11_+_5646213 4.50 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr12_+_113416340 4.39 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr18_-_8337038 4.26 ENST00000594251.1
AP001094.1
Uncharacterized protein
chr11_-_57335280 4.25 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr20_+_388679 4.03 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_150480551 3.78 ENST00000369049.4
ENST00000369047.4
ECM1
extracellular matrix protein 1
chr20_+_388935 3.45 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr6_-_32806483 3.28 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_-_77656175 3.26 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
CTD-2037K23.2
chr10_-_22292675 3.26 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr12_-_10022735 3.16 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr6_-_36355486 3.14 ENST00000538992.1
ETV7
ets variant 7
chr7_+_134832808 3.10 ENST00000275767.3
TMEM140
transmembrane protein 140
chr1_+_150480576 3.05 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr17_-_40264692 2.84 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr7_-_138794394 2.63 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr1_-_161015752 2.63 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chr2_-_37384175 2.58 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr1_-_89664595 2.50 ENST00000355754.6
GBP4
guanylate binding protein 4
chr3_+_122399697 2.42 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr22_+_39436862 2.24 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr4_+_130017268 2.19 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr14_-_24615523 2.13 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_+_25958174 2.00 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr20_-_47894936 1.96 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr14_-_24615805 1.87 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_110577229 1.74 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr12_-_133613794 1.71 ENST00000443154.3
RP11-386I8.6
RP11-386I8.6
chr6_+_26402465 1.71 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr10_-_49701686 1.70 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr14_-_91976874 1.60 ENST00000557018.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr8_+_39770803 1.51 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr12_-_133787772 1.50 ENST00000545350.1
AC226150.4
Uncharacterized protein
chr4_+_118955500 1.40 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_+_131746575 1.28 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr3_+_122283175 1.22 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr20_-_61847455 1.22 ENST00000370334.4
YTHDF1
YTH domain family, member 1
chrX_+_57313113 1.19 ENST00000374900.4
FAAH2
fatty acid amide hydrolase 2
chr17_+_6659354 1.15 ENST00000574907.1
XAF1
XIAP associated factor 1
chr16_+_29127282 1.15 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr7_-_138794081 1.13 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr9_+_77112244 1.12 ENST00000376896.3
RORB
RAR-related orphan receptor B
chrX_+_146993648 1.09 ENST00000370470.1
FMR1
fragile X mental retardation 1
chr10_-_14996017 1.08 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DCLRE1C
DNA cross-link repair 1C
chr12_-_11339543 1.08 ENST00000334266.1
TAS2R42
taste receptor, type 2, member 42
chr12_-_322821 1.03 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr6_-_3752222 1.02 ENST00000380283.4
PXDC1
PX domain containing 1
chr6_+_26402517 0.98 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr7_-_32931387 0.86 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr17_+_8316442 0.80 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr14_+_24605389 0.79 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_-_8218997 0.72 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr1_-_154580616 0.70 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr19_+_50887585 0.69 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr3_-_125802998 0.59 ENST00000514677.1
SLC41A3
solute carrier family 41, member 3
chr11_+_124735282 0.57 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr22_+_31892261 0.55 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr22_+_31892373 0.54 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr15_+_64428529 0.50 ENST00000560861.1
SNX1
sorting nexin 1
chr1_-_177939041 0.48 ENST00000308284.6
SEC16B
SEC16 homolog B (S. cerevisiae)
chr12_-_4758159 0.48 ENST00000545990.2
AKAP3
A kinase (PRKA) anchor protein 3
chr9_+_140083099 0.43 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr8_-_67525473 0.43 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr19_+_39926791 0.42 ENST00000594990.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr10_+_35415978 0.37 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr14_+_24605361 0.36 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr6_+_42018614 0.35 ENST00000465926.1
ENST00000482432.1
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr12_+_133614062 0.33 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chrX_+_146993449 0.33 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr6_-_2876744 0.31 ENST00000420981.2
RP11-420G6.4
RP11-420G6.4
chr6_-_90529418 0.27 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr3_+_183815318 0.26 ENST00000425359.2
HTR3E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
chr3_+_186649133 0.21 ENST00000417392.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_25598989 0.18 ENST00000454452.2
RHD
Rh blood group, D antigen
chr2_-_214017151 0.17 ENST00000452786.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr17_+_36861735 0.17 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr3_-_71114066 0.15 ENST00000485326.2
FOXP1
forkhead box P1
chr14_-_100841670 0.15 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr16_+_66968343 0.13 ENST00000417689.1
ENST00000561697.1
ENST00000317091.4
ENST00000566182.1
CES2
carboxylesterase 2
chr2_+_201981119 0.13 ENST00000395148.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_+_151129135 0.12 ENST00000602841.1
SCNM1
sodium channel modifier 1
chr3_-_160283348 0.11 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr8_+_22446763 0.07 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr12_-_54582655 0.06 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr5_-_96143602 0.04 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr1_+_25599018 0.03 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
6.0 24.1 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
6.0 84.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
4.0 16.0 GO:0046967 cytosol to ER transport(GO:0046967)
3.9 47.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.7 15.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
3.4 37.8 GO:0018377 protein myristoylation(GO:0018377)
2.7 29.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.9 22.5 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.8 14.7 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
1.7 6.9 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
1.7 5.0 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
1.6 23.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
1.2 12.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
1.1 22.1 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.7 8.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.7 3.9 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.5 1.5 GO:0036269 swimming behavior(GO:0036269)
0.4 1.3 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.4 2.6 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.4 17.6 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.3 2.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.3 27.9 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.3 1.8 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.2 0.7 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 6.2 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.2 6.8 GO:2000404 regulation of T cell migration(GO:2000404)
0.2 8.2 GO:0035456 response to interferon-beta(GO:0035456)
0.2 1.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 4.6 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 6.2 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 3.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.7 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 11.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 1.4 GO:0030202 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 4.7 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 0.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.7 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.6 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 4.5 GO:0070206 protein trimerization(GO:0070206)
0.0 0.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 1.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 3.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.5 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.4 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 10.3 GO:0009615 response to virus(GO:0009615)
0.0 1.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 6.5 GO:0006869 lipid transport(GO:0006869)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 GO:0032002 interleukin-28 receptor complex(GO:0032002)
2.3 16.0 GO:0042825 TAP complex(GO:0042825)
2.1 12.3 GO:0071797 LUBAC complex(GO:0071797)
0.9 5.2 GO:0008537 proteasome activator complex(GO:0008537)
0.8 6.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 2.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.6 18.4 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4 1.3 GO:1902737 dendritic filopodium(GO:1902737)
0.4 6.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.3 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 0.8 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.7 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 21.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.9 GO:0016589 NURF complex(GO:0016589)
0.1 0.4 GO:0032044 DSIF complex(GO:0032044)
0.1 4.5 GO:0005771 multivesicular body(GO:0005771)
0.1 0.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 11.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 4.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 54.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 19.4 GO:0005769 early endosome(GO:0005769)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 5.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 5.6 GO:0009986 cell surface(GO:0009986)
0.0 40.2 GO:0005739 mitochondrion(GO:0005739)
0.0 31.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.7 GO:0035577 azurophil granule membrane(GO:0035577)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 60.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
2.1 20.6 GO:0042296 ISG15 transferase activity(GO:0042296)
2.0 26.6 GO:0031386 protein tag(GO:0031386)
1.8 16.0 GO:0015440 peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
1.5 27.9 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
1.4 5.6 GO:0031849 olfactory receptor binding(GO:0031849)
1.1 6.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.0 29.4 GO:0070403 NAD+ binding(GO:0070403)
0.6 5.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.6 4.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.5 17.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.5 2.0 GO:0048030 disaccharide binding(GO:0048030)
0.4 2.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 2.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.4 1.5 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.3 14.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.3 33.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 6.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 0.8 GO:0070012 oligopeptidase activity(GO:0070012)
0.2 5.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 21.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 18.4 GO:0005254 chloride channel activity(GO:0005254)
0.1 5.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.8 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.1 0.5 GO:1990460 leptin receptor binding(GO:1990460)
0.1 1.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 10.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.7 GO:0004875 complement receptor activity(GO:0004875)
0.1 3.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 22.1 GO:0008017 microtubule binding(GO:0008017)
0.0 0.7 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.3 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 7.3 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 7.5 GO:0004386 helicase activity(GO:0004386)
0.0 5.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 4.7 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 5.2 GO:0042393 histone binding(GO:0042393)
0.0 41.1 GO:0042802 identical protein binding(GO:0042802)
0.0 5.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 2.5 GO:0003924 GTPase activity(GO:0003924)
0.0 16.8 GO:0004871 signal transducer activity(GO:0004871)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.7 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 24.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 8.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.6 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 5.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 6.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 245.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.8 28.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 20.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.4 12.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.4 6.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.2 2.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 11.3 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 3.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 25.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 2.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 1.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.7 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.0 0.4 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat