ISMARA results: IRF3

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 7.23

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Transcription factors associated with IRF3

Gene Symbol	Gene ID	Gene Info
IRF3 Ensembl NCBI GeneCards UniProt	ENSG00000126456.11	interferon regulatory factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF3	hg19_v2_chr19_-_50168861_50168873	0.80	2.0e-01	Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_91087651 Show fit	35.55	ENST00000371818.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91092241 Show fit	29.32	ENST00000371811.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr1_+_948803 Show fit	26.64	ENST00000379389.4	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin-like modifier
chr21_+_42792442 Show fit	22.07	ENST00000398600.2	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_+_91061712 Show fit	19.38	ENST00000371826.3	IFIT2 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 2
chr12_+_113416191 Show fit	19.34	ENST00000342315.4 ENST00000392583.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr1_+_79115503 Show fit	16.85	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 44
chr2_-_163175133 Show fit	16.69	ENST00000421365.2 ENST00000263642.2	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr19_+_39786962 Show fit	14.99	ENST00000333625.2	IFNL1 Ensembl NCBI GeneCards UniProt Show fit	interferon, lambda 1
chr16_-_11350036 Show fit	14.74	ENST00000332029.2	SOCS1 Ensembl NCBI GeneCards UniProt Show fit	suppressor of cytokine signaling 1

Showing 1 to 10 of 144 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.0	84.2	GO:0035457	cellular response to interferon-alpha(GO:0035457)
3.9	47.3	GO:0032020	ISG15-protein conjugation(GO:0032020)
3.4	37.8	GO:0018377	protein myristoylation(GO:0018377)
2.7	29.4	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
7.1	28.3	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.3	27.9	GO:0060135	maternal process involved in female pregnancy(GO:0060135)
6.0	24.1	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
1.6	23.9	GO:0034058	endosomal vesicle fusion(GO:0034058)
1.9	22.5	GO:0060700	regulation of ribonuclease activity(GO:0060700)
1.1	22.1	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)

Showing 1 to 10 of 55 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	54.8	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.0	40.2	GO:0005739	mitochondrion(GO:0005739)
0.0	31.8	GO:0005783	endoplasmic reticulum(GO:0005783)
0.1	21.7	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	19.4	GO:0005769	early endosome(GO:0005769)
0.6	18.4	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
2.3	16.0	GO:0042825	TAP complex(GO:0042825)
5.0	15.0	GO:0032002	interleukin-28 receptor complex(GO:0032002)
2.1	12.3	GO:0071797	LUBAC complex(GO:0071797)
0.1	11.6	GO:0032587	ruffle membrane(GO:0032587)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.0	60.3	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	41.1	GO:0042802	identical protein binding(GO:0042802)
0.3	33.6	GO:0003725	double-stranded RNA binding(GO:0003725)
1.0	29.4	GO:0070403	NAD+ binding(GO:0070403)
1.5	27.9	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
2.0	26.6	GO:0031386	protein tag(GO:0031386)
0.0	22.1	GO:0008017	microtubule binding(GO:0008017)
0.2	21.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
2.1	20.6	GO:0042296	ISG15 transferase activity(GO:0042296)
0.1	18.4	GO:0005254	chloride channel activity(GO:0005254)

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	14.7	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.1	8.1	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	7.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	6.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	5.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	3.4	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	2.6	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	1.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Showing 1 to 10 of 11 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	245.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.8	28.3	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	25.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4	20.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.4	12.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	11.3	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.4	6.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	3.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	2.7	REACTOME INTERFERON SIGNALING	Genes involved in Interferon Signaling
0.0	2.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling

Showing 1 to 10 of 16 entries

Results for IRF3

Z-value: 7.23

Motif logo

Transcription factors associated with IRF3

Activity-expression correlation:

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: