ISMARA results: INSM1

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for INSM1

Z-value: 2.27

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Transcription factors associated with INSM1

Gene Symbol	Gene ID	Gene Info
INSM1 Ensembl NCBI GeneCards UniProt	ENSG00000173404.3	INSM transcriptional repressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
INSM1	hg19_v2_chr20_+_20348740_20348765	0.44	5.6e-01	Click!

Activity profile of INSM1 motif

Sorted Z-values of INSM1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_91061712 Show fit	4.63	ENST00000371826.3	IFIT2 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 2
chr15_+_45722727 Show fit	4.62	ENST00000396650.2 ENST00000558435.1 ENST00000344300.3	C15orf48 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 48
chr19_+_10197463 Show fit	3.32	ENST00000590378.1 ENST00000397881.3	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr15_+_89182156 Show fit	2.84	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 Show fit	2.70	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr19_-_55881741 Show fit	2.41	ENST00000264563.2 ENST00000590625.1 ENST00000585513.1	IL11 Ensembl NCBI GeneCards UniProt Show fit	interleukin 11
chr19_+_10196781 Show fit	2.16	ENST00000253110.11	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr15_+_89181974 Show fit	2.11	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr12_+_70760056 Show fit	2.00	ENST00000258111.4	KCNMB4 Ensembl NCBI GeneCards UniProt Show fit	potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr20_+_48807351 Show fit	1.55	ENST00000303004.3	CEBPB Ensembl NCBI GeneCards UniProt Show fit	CCAAT/enhancer binding protein (C/EBP), beta

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of INSM1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	7.7	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.3	4.6	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.6	2.8	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.4	2.4	GO:1903659	regulation of complement-dependent cytotoxicity(GO:1903659)
0.1	1.6	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.3	1.5	GO:0052250	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0	1.5	GO:0032465	regulation of cytokinesis(GO:0032465)
0.1	1.3	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1	1.2	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.1	1.2	GO:0005513	detection of calcium ion(GO:0005513)

Showing 1 to 10 of 76 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.6	GO:0015030	Cajal body(GO:0015030)
0.1	2.8	GO:0097227	sperm annulus(GO:0097227)
0.0	1.4	GO:0071004	U2-type prespliceosome(GO:0071004)
0.2	1.3	GO:0070436	Grb2-EGFR complex(GO:0070436)
0.1	0.8	GO:0070826	paraferritin complex(GO:0070826)
0.0	0.8	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.8	GO:0031143	pseudopodium(GO:0031143)
0.0	0.8	GO:0045095	keratin filament(GO:0045095)
0.1	0.7	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	0.7	GO:0030991	intraciliary transport particle A(GO:0030991)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	7.7	GO:0008859	exoribonuclease II activity(GO:0008859)
0.0	2.1	GO:0070851	growth factor receptor binding(GO:0070851)
0.1	2.0	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.1	1.6	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.1	1.5	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	1.5	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	1.4	GO:0070064	proline-rich region binding(GO:0070064)
0.0	1.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.3	1.0	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	1.0	GO:0003696	satellite DNA binding(GO:0003696)

Showing 1 to 10 of 59 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.1	PID IL3 PATHWAY	IL3-mediated signaling events
1.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
1.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.9	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.8	PID S1P S1P4 PATHWAY	S1P4 pathway
0.6	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.6	PID EPHA FWDPATHWAY	EPHA forward signaling
0.6	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.3	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	1.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	1.5	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.0	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	1.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.7	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.6	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.5	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins

Showing 1 to 10 of 15 entries

Results for INSM1

Z-value: 2.27

Motif logo

Transcription factors associated with INSM1

Activity-expression correlation:

Activity profile of INSM1 motif

Sorted Z-values of INSM1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of INSM1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: