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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HSF2
Z-value: 1.66
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Transcription factors associated with HSF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF2 | hg19_v2_chr6_+_122720681_122720713 | -0.96 | 4.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_33025209 Show fit | 1.60 |
ENST00000330899.4
ENST00000544625.1 |
DnaJ (Hsp40) homolog, subfamily A, member 1 |
|
| chr14_-_67859422 Show fit | 1.40 |
ENST00000556532.1
|
pleckstrin 2 |
|
| chrX_+_135279179 Show fit | 1.31 |
ENST00000370676.3
|
four and a half LIM domains 1 |
|
| chr12_-_10007448 Show fit | 1.27 |
ENST00000538152.1
|
C-type lectin domain family 2, member B |
|
| chrX_+_135230712 Show fit | 0.94 |
ENST00000535737.1
|
four and a half LIM domains 1 |
|
| chrX_+_135278908 Show fit | 0.92 |
ENST00000539015.1
ENST00000370683.1 |
four and a half LIM domains 1 |
|
| chr1_-_228613026 Show fit | 0.91 |
ENST00000366696.1
|
histone cluster 3, H3 |
|
| chr15_-_81616446 Show fit | 0.90 |
ENST00000302824.6
|
StAR-related lipid transfer (START) domain containing 5 |
|
| chr1_+_41448820 Show fit | 0.89 |
ENST00000372616.1
|
CTP synthase 1 |
|
| chr1_-_6453399 Show fit | 0.85 |
ENST00000608083.1
|
acyl-CoA thioesterase 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.4 | 1.6 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.1 | 1.3 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 0.2 | 1.1 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.1 | 1.0 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.2 | 0.9 | GO:0044210 | 'de novo' CTP biosynthetic process(GO:0044210) |
| 0.0 | 0.9 | GO:0070508 | sterol import(GO:0035376) cholesterol import(GO:0070508) |
| 0.0 | 0.9 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.3 | 0.8 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.2 | 0.8 | GO:0010193 | response to ozone(GO:0010193) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.6 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 1.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 1.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.2 | 1.1 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 0.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 0.8 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 0.7 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.0 | 0.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.5 | GO:0005858 | axonemal dynein complex(GO:0005858) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 2.3 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.2 | 1.6 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.0 | 1.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 1.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.1 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.1 | 1.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 0.9 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.0 | 0.9 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.0 | 0.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.6 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.8 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 0.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |