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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HSF1
Z-value: 2.21
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Transcription factors associated with HSF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF1 | hg19_v2_chr8_+_145515263_145515299 | 0.32 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_191878162 Show fit | 2.66 |
ENST00000540176.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chrX_+_150866779 Show fit | 2.57 |
ENST00000370353.3
|
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) |
|
| chr7_-_139763521 Show fit | 2.54 |
ENST00000263549.3
|
poly (ADP-ribose) polymerase family, member 12 |
|
| chr2_-_191878874 Show fit | 2.17 |
ENST00000392322.3
ENST00000392323.2 ENST00000424722.1 ENST00000361099.3 |
signal transducer and activator of transcription 1, 91kDa |
|
| chr1_+_161494036 Show fit | 2.07 |
ENST00000309758.4
|
heat shock 70kDa protein 6 (HSP70B') |
|
| chr2_-_191878681 Show fit | 2.06 |
ENST00000409465.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr11_+_64323098 Show fit | 1.91 |
ENST00000301891.4
|
solute carrier family 22 (organic anion/urate transporter), member 11 |
|
| chr6_+_47666275 Show fit | 1.52 |
ENST00000327753.3
ENST00000283303.2 |
G protein-coupled receptor 115 |
|
| chr20_-_23669590 Show fit | 1.41 |
ENST00000217423.3
|
cystatin S |
|
| chr20_-_23731893 Show fit | 1.31 |
ENST00000398402.1
|
cystatin SN |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 8.2 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.0 | 4.1 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.4 | 2.7 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.1 | 2.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 1.9 | GO:0015747 | urate transport(GO:0015747) |
| 0.4 | 1.3 | GO:0002232 | leukocyte chemotaxis involved in inflammatory response(GO:0002232) |
| 0.0 | 1.3 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 0.3 | 1.1 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.0 | 1.1 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 1.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.2 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.3 | 2.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 1.9 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 1.8 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.1 | 1.3 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 1.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 1.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.9 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 0.9 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.5 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 3.4 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 3.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 2.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 1.9 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 1.9 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 1.4 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 1.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.2 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.2 | 1.1 | GO:0050294 | steroid sulfotransferase activity(GO:0050294) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.9 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.8 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 3.3 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 2.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 1.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.3 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 1.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.1 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.0 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.0 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 1.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |