ISMARA results: HOXC8

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HOXC8

Z-value: 2.03

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Transcription factors associated with HOXC8

Gene Symbol	Gene ID	Gene Info
HOXC8 Ensembl NCBI GeneCards UniProt	ENSG00000037965.4	homeobox C8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC8	hg19_v2_chr12_+_54402790_54402832	-0.63	3.7e-01	Click!

Activity profile of HOXC8 motif

Sorted Z-values of HOXC8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_89442940 Show fit	2.38	ENST00000527353.1	PIGY Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class Y
chr1_+_76251912 Show fit	1.70	ENST00000370826.3	RABGGTB Ensembl NCBI GeneCards UniProt Show fit	Rab geranylgeranyltransferase, beta subunit
chr17_-_64216748 Show fit	1.58	ENST00000585162.1	APOH Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein H (beta-2-glycoprotein I)
chr11_-_104035088 Show fit	1.31	ENST00000302251.5	PDGFD Ensembl NCBI GeneCards UniProt Show fit	platelet derived growth factor D
chr13_+_34392185 Show fit	1.23	ENST00000380071.3	RFC3 Ensembl NCBI GeneCards UniProt Show fit	replication factor C (activator 1) 3, 38kDa
chr8_-_27695552 Show fit	1.23	ENST00000522944.1 ENST00000301905.4	PBK Ensembl NCBI GeneCards UniProt Show fit	PDZ binding kinase
chr10_+_115312766 Show fit	1.21	ENST00000351270.3	HABP2 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan binding protein 2
chr10_-_101841588 Show fit	1.11	ENST00000370418.3	CPN1 Ensembl NCBI GeneCards UniProt Show fit	carboxypeptidase N, polypeptide 1
chr12_-_91573132 Show fit	1.10	ENST00000550563.1 ENST00000546370.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr6_-_27806117 Show fit	1.08	ENST00000330180.2	HIST1H2AK Ensembl NCBI GeneCards UniProt Show fit	histone cluster 1, H2ak

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0006505	GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.1	2.1	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.3	1.9	GO:0014038	regulation of Schwann cell differentiation(GO:0014038)
0.2	1.9	GO:0018344	protein geranylgeranylation(GO:0018344)
0.2	1.8	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.2	1.7	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1	1.6	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2	1.5	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	1.4	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.4	1.3	GO:0035696	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)

Showing 1 to 10 of 329 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2	2.4	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	2.1	GO:0035371	microtubule plus-end(GO:0035371)
0.4	1.9	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.4	1.8	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.2	1.7	GO:0005663	DNA replication factor C complex(GO:0005663)
0.1	1.6	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	1.6	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.0	1.4	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	1.3	GO:0043596	nuclear replication fork(GO:0043596)

Showing 1 to 10 of 131 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	2.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3	1.9	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.2	1.7	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	1.7	GO:0047485	protein N-terminus binding(GO:0047485)
0.5	1.5	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	1.5	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	1.4	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	1.3	GO:0003777	microtubule motor activity(GO:0003777)
0.1	1.2	GO:0045504	dynein heavy chain binding(GO:0045504)

Showing 1 to 10 of 205 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	PID ATR PATHWAY	ATR signaling pathway
0.0	2.7	PID AURORA B PATHWAY	Aurora B signaling
0.0	2.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	1.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	1.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	1.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	1.5	PID E2F PATHWAY	E2F transcription factor network
0.0	1.1	PID MYC PATHWAY	C-MYC pathway
0.0	1.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.0	PID FANCONI PATHWAY	Fanconi anemia pathway

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	2.5	REACTOME KINESINS	Genes involved in Kinesins
0.1	2.1	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1	1.8	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	1.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	1.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	1.5	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	1.5	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	1.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins

Showing 1 to 10 of 71 entries

Results for HOXC8

Z-value: 2.03

Motif logo

Transcription factors associated with HOXC8

Activity-expression correlation:

Activity profile of HOXC8 motif

Sorted Z-values of HOXC8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: