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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HOXB7
Z-value: 1.06
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Transcription factors associated with HOXB7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB7 | hg19_v2_chr17_-_46688334_46688385 | -0.95 | 4.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.5 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.0 | 1.2 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.0 | 0.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.2 | 0.8 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.1 | 0.8 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.7 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.7 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770) |
| 0.0 | 0.7 | GO:0010824 | regulation of centrosome duplication(GO:0010824) |
| 0.1 | 0.6 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.1 | 0.6 | GO:1901189 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.7 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 0.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.4 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.1 | 0.4 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.4 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.1 | 0.3 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 0.3 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 1.0 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.3 | 0.8 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.2 | 0.7 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 0.0 | 0.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.6 | GO:0008430 | selenium binding(GO:0008430) inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.6 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 0.5 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.0 | 0.5 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.4 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.6 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 0.5 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.3 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |