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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HOXB6_PRRX2
Z-value: 1.07
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX2 | hg19_v2_chr9_+_132427883_132427951 | 0.35 | 6.5e-01 | Click! |
| HOXB6 | hg19_v2_chr17_-_46682321_46682362 | 0.22 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_176733897 Show fit | 1.58 |
ENST00000393658.2
|
glycoprotein M6A |
|
| chr4_-_41884582 Show fit | 1.07 |
ENST00000499082.2
|
long intergenic non-protein coding RNA 682 |
|
| chr14_-_95236551 Show fit | 1.06 |
ENST00000238558.3
|
goosecoid homeobox |
|
| chr17_+_79369249 Show fit | 0.97 |
ENST00000574717.2
|
Uncharacterized protein |
|
| chr2_-_182545603 Show fit | 0.93 |
ENST00000295108.3
|
neuronal differentiation 1 |
|
| chr2_-_145188137 Show fit | 0.91 |
ENST00000440875.1
|
zinc finger E-box binding homeobox 2 |
|
| chr14_-_37051798 Show fit | 0.87 |
ENST00000258829.5
|
NK2 homeobox 8 |
|
| chr17_-_46716647 Show fit | 0.73 |
ENST00000608940.1
|
RP11-357H14.17 |
|
| chr12_-_89746264 Show fit | 0.71 |
ENST00000548755.1
|
dual specificity phosphatase 6 |
|
| chr2_+_177015950 Show fit | 0.71 |
ENST00000306324.3
|
homeobox D4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 1.9 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.2 | 1.6 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.0 | 1.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.1 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.1 | 1.0 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 1.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 0.9 | GO:0060730 | regulation of intestinal epithelial structure maintenance(GO:0060730) |
| 0.2 | 0.8 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.0 | 0.8 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.3 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.0 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.0 | 0.8 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.5 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 0.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.3 | GO:0032279 | asymmetric synapse(GO:0032279) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 1.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 1.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.3 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 1.0 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 1.0 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 1.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.6 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.5 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.8 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.8 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.3 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.3 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |