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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HOXB5

Z-value: 0.48

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_46671323-0.955.0e-02Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_32820529 0.58 ENST00000425148.2
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_+_146373546 0.34 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr19_-_12267524 0.25 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr6_-_97285336 0.23 ENST00000229955.3
ENST00000417980.1
GPR63
G protein-coupled receptor 63
chr19_-_16045220 0.23 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr1_-_155658260 0.22 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
YY1AP1
YY1 associated protein 1
chr3_+_51422478 0.20 ENST00000528157.1
MANF
mesencephalic astrocyte-derived neurotrophic factor
chrX_+_48380205 0.19 ENST00000446158.1
ENST00000414061.1
EBP
emopamil binding protein (sterol isomerase)
chrX_+_135230712 0.19 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr16_-_9770700 0.19 ENST00000561538.1
RP11-297M9.1
Uncharacterized protein
chr3_+_190281229 0.18 ENST00000453359.1
IL1RAP
interleukin 1 receptor accessory protein
chr11_-_125648690 0.17 ENST00000436890.2
ENST00000358524.3
PATE2
prostate and testis expressed 2
chr1_+_41157671 0.17 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr6_-_31509506 0.17 ENST00000449757.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_+_157963391 0.17 ENST00000359209.6
ENST00000416935.2
KIRREL
kin of IRRE like (Drosophila)
chr1_+_162351503 0.16 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr17_+_2496971 0.16 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr12_+_57984943 0.16 ENST00000422156.3
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr17_+_46970178 0.16 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr18_-_33077556 0.16 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr16_-_84651647 0.15 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr12_+_56915713 0.15 ENST00000262031.5
ENST00000552247.2
RBMS2
RNA binding motif, single stranded interacting protein 2
chr19_-_42724261 0.14 ENST00000595337.1
DEDD2
death effector domain containing 2
chr17_+_46970127 0.14 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr6_-_31509714 0.14 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr6_+_30749649 0.14 ENST00000422944.1
HCG20
HLA complex group 20 (non-protein coding)
chr7_+_125557914 0.13 ENST00000411856.1
AC005276.1
AC005276.1
chr12_-_52715179 0.13 ENST00000293670.3
KRT83
keratin 83
chr19_+_34745442 0.13 ENST00000299505.6
ENST00000588470.1
ENST00000589583.1
ENST00000588338.2
KIAA0355
KIAA0355
chr2_-_47168850 0.13 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr1_+_41157421 0.12 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr1_-_155658085 0.12 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr15_-_72523454 0.12 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
PKM
pyruvate kinase, muscle
chr6_-_31510181 0.12 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_-_155658518 0.12 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
YY1AP1
YY1 associated protein 1
chr3_-_164914640 0.12 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr14_-_102704783 0.12 ENST00000522534.1
MOK
MOK protein kinase
chr14_-_24020858 0.11 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr1_+_41157361 0.11 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr12_+_53693466 0.11 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr17_+_46970134 0.11 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chrM_+_12331 0.11 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr16_-_1821721 0.10 ENST00000219302.3
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr1_+_155658849 0.09 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr1_-_155658766 0.09 ENST00000295566.4
ENST00000368330.2
YY1AP1
YY1 associated protein 1
chr1_+_154229547 0.09 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr20_-_6034672 0.09 ENST00000378858.4
LRRN4
leucine rich repeat neuronal 4
chr2_+_17721920 0.08 ENST00000295156.4
VSNL1
visinin-like 1
chr2_-_74726710 0.08 ENST00000377566.4
LBX2
ladybird homeobox 2
chr15_+_41913690 0.08 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr6_+_121756809 0.08 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr12_+_66217911 0.07 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr12_-_6798523 0.07 ENST00000319770.3
ZNF384
zinc finger protein 384
chr16_-_58004992 0.07 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr2_-_47168906 0.07 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr12_-_6798616 0.07 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr15_+_74218787 0.06 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr7_+_120969045 0.06 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr1_+_145575227 0.06 ENST00000393046.2
ENST00000369299.3
ENST00000463514.2
PIAS3
protein inhibitor of activated STAT, 3
chr1_+_155579979 0.06 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr15_-_75017711 0.05 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr1_+_154975110 0.05 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr16_-_1821496 0.04 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr14_+_21945335 0.04 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr20_-_49308048 0.04 ENST00000327979.2
FAM65C
family with sequence similarity 65, member C
chr3_+_45986511 0.04 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr11_-_35440579 0.04 ENST00000606205.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_+_17721937 0.03 ENST00000451533.1
VSNL1
visinin-like 1
chr12_-_101801505 0.03 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr1_+_206317591 0.03 ENST00000432969.2
CTSE
cathepsin E
chr14_+_38660185 0.03 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr1_+_145575980 0.03 ENST00000393045.2
PIAS3
protein inhibitor of activated STAT, 3
chr12_+_56915776 0.03 ENST00000550726.1
ENST00000542360.1
RBMS2
RNA binding motif, single stranded interacting protein 2
chr4_-_114900831 0.02 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr1_+_145576007 0.02 ENST00000369298.1
PIAS3
protein inhibitor of activated STAT, 3
chr3_-_195538728 0.02 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr6_-_29395509 0.02 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr9_-_130700080 0.02 ENST00000373110.4
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr12_-_75601778 0.02 ENST00000550433.1
ENST00000548513.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr1_+_206317450 0.02 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr20_+_44074071 0.02 ENST00000595203.1
AL031663.2
CDNA FLJ26875 fis, clone PRS08969; Uncharacterized protein
chr17_-_17140436 0.01 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
FLCN
folliculin
chr19_-_50143452 0.01 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr17_-_42143963 0.01 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_113263199 0.01 ENST00000361886.3
FAM19A3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
chr6_-_29396243 0.01 ENST00000377148.1
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr1_+_116915855 0.01 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_-_195538760 0.01 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr16_-_30381580 0.01 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chrX_+_100333709 0.01 ENST00000372930.4
TMEM35
transmembrane protein 35
chr20_-_3687775 0.01 ENST00000344754.4
ENST00000202578.4
SIGLEC1
sialic acid binding Ig-like lectin 1, sialoadhesin
chr13_-_64650144 0.01 ENST00000456627.1
LINC00355
long intergenic non-protein coding RNA 355
chr17_-_29233221 0.00 ENST00000580840.1
TEFM
transcription elongation factor, mitochondrial
chr2_-_220173685 0.00 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN
protein tyrosine phosphatase, receptor type, N

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.2 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.2 GO:0046469 platelet activating factor metabolic process(GO:0046469)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:1903367 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0 0.1 GO:2000685 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.1 GO:0043449 insecticide metabolic process(GO:0017143) cellular alkene metabolic process(GO:0043449)
0.0 0.1 GO:0018277 protein deamination(GO:0018277)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.0 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042825 TAP complex(GO:0042825)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.7 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.0 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC