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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for HOXB4_LHX9
Z-value: 1.35
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Transcription factors associated with HOXB4_LHX9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX9 | hg19_v2_chr1_+_197881592_197881635 | 0.91 | 8.9e-02 | Click! |
| HOXB4 | hg19_v2_chr17_-_46657473_46657473 | -0.60 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_5710919 Show fit | 4.01 |
ENST00000379965.3
ENST00000425490.1 |
tripartite motif containing 22 |
|
| chr19_+_54466179 Show fit | 2.80 |
ENST00000270458.2
|
calcium channel, voltage-dependent, gamma subunit 8 |
|
| chr11_-_327537 Show fit | 2.27 |
ENST00000602735.1
|
interferon induced transmembrane protein 3 |
|
| chr14_-_67878917 Show fit | 1.78 |
ENST00000216446.4
|
pleckstrin 2 |
|
| chr19_-_3557570 Show fit | 1.65 |
ENST00000355415.2
|
major facilitator superfamily domain containing 12 |
|
| chr20_-_56265680 Show fit | 1.14 |
ENST00000414037.1
|
prostate transmembrane protein, androgen induced 1 |
|
| chr5_-_126409159 Show fit | 1.03 |
ENST00000607731.1
ENST00000535381.1 ENST00000296662.5 ENST00000509733.3 |
chromosome 5 open reading frame 63 |
|
| chrX_+_10126488 Show fit | 0.94 |
ENST00000380829.1
ENST00000421085.2 ENST00000454850.1 |
chloride channel, voltage-sensitive 4 |
|
| chr15_+_64680003 Show fit | 0.92 |
ENST00000261884.3
|
thyroid hormone receptor interactor 4 |
|
| chr15_+_90735145 Show fit | 0.87 |
ENST00000559792.1
|
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB4_LHX9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.1 | 2.8 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 2.3 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 1.6 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.1 | 1.5 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.1 | 1.1 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 1.0 | GO:0060746 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.0 | 1.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 1.0 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 1.0 | GO:0050798 | activated T cell proliferation(GO:0050798) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 3.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 2.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.0 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.3 | 1.5 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 1.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 1.0 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 1.0 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.2 | 0.9 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.0 | 0.9 | GO:0036020 | endolysosome membrane(GO:0036020) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 3.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 2.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 1.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 1.3 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.0 | 1.3 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 1.0 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 1.0 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 1.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 0.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 2.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 1.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.1 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.0 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 1.0 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |